Mathematical modeling of extracorporeal CO2 removal therapy. A validation carried out on ten pigs

[en] The extracorporeal CO2 removal device (ECCO2RD) is used in clinics to treat patients suffering from respiratory failures like acute respiratory distress syn- drome (ARDS) or chronic obstructive pulmonary disease (COPD). The aim of this device is to decarboxylate blood externally with low blood flow. A mathematical model is proposed to describe protective ventilation, ARDS, and an extracorporeal CO2 removal therapy (ECCO2RT). The sim- ulations are compared with experimental data carried out on ten pigs. The results show a good agreement between the mathematical simulations and the experimental data, which provides a nice validation of the model. This model is thus able to predict the decrease of PCO2 during ECCO2RT for different blood flows across the extracorporeal lung support.

Disciplines :

Engineering, computing & technology: Multidisciplinary, general & others

Author, co-author :

Habran, Simon ; Université de Liège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles

Desaive, Thomas ; Université de Liège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles

MORIMONT, Philippe ; Centre Hospitalier Universitaire de Liège - CHU > Frais communs médecine - Pool assistants

LAMBERMONT, Bernard ; Centre Hospitalier Universitaire de Liège - CHU > Frais communs médecine - Pool assistants

Dauby, Pierre ; Université de Liège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles

Language :

English

Title :

Mathematical modeling of extracorporeal CO2 removal therapy. A validation carried out on ten pigs

Publication date :

09 March 2018

Journal title :

Medical and Biological Engineering and Computing

ISSN :

0140-0118

eISSN :

1741-0444

Publisher :

Springer

Volume :

Issue :

Pages :

421-434

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://doi.org/10.1007/s11517-017-1694-y

Available on ORBi :

since 06 October 2017

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