Reference : Disseminated histoplasmosis: case report and review of the literature
Scientific journals : Article
Life sciences : Animal production & animal husbandry
http://hdl.handle.net/2268/214760
Disseminated histoplasmosis: case report and review of the literature
English
Evrard, Séverine [Centre Hospitalier Régionale de la Citadelle (Liège) - CHR CITADELLE > Laboratoire médical > > >]
CAPRASSE, Philippe mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service des maladies infectieuses - médecine interne >]
Gavage, Pierre [Centre Hospitalier Régionale de la Citadelle (Liège) - CHR CITADELLE > Laboratoire médical > > >]
Vasbien, Myriam [Centre Hospitalier Régionale de la Citadelle (Liège) - CHR CITADELLE > Laboratoire médical > > >]
Radermacher, Jean [Centre Hospitalier Régionale de la Citadelle (Liège) - CHR CITADELLE > Anatomopathologie > > >]
HAYETTE, Marie-Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service de microbiologie clinique >]
SACHELI, Rosalie mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service de microbiologie clinique >]
Van Esbroeck, Marjan [Institut de Médecine Tropicale Anvers > Sciences cliniques > > >]
Cnops, Lieselotte [Institut de médecine Tropicale Anvers > Sciences cliniques > > >]
Firre, Eric [Centre Hospitalier Régionale de la Citadelle (Liège) - CHR CITADELLE > Infectiologie > > >]
Médart, Laurent [Centre Hospitalier Régionale de la Citadelle (Liège) - CHR CITADELLE > Radiologie > > >]
Moerman, Philippe [Centre Hospitalier Régionale de la Citadelle (Liège) - CHR CITADELLE > Infectiologie > > >]
Minon, Jean-marc [Centre Hospitalier Régionale de la Citadelle (Liège) - CHR CITADELLE > Laboratoire medical > > >]
Oct-2017
Acta Clinica Belgica
Taylor & Francis
Yes (verified by ORBi)
International
1784-3286
2295-3337
[en] Histoplasmosis
[en] Case report: We report the case of a young Cameroonian woman who presented with cough,
hyperthermia, weight loss, pancytopenia, and hepatosplenomegaly. A positive HIV serology
was discovered and a chest radiography revealed a ‘miliary pattern’. Bone marrow aspiration
pointed out yeast inclusions within macrophages. Given the morphological aspect, the clinical
presentation and immunosuppression, histoplasmosis was retained as a working hypothesis.
Antiretroviral and amphotericin B treatments were promptly initiated.
Review: Given the immigration wave that Europe is currently experiencing, we think it is
important to share experience and knowledge, especially in non-endemic areas such as
Europe, where clinicians are not used to face this disease. Histoplasmosis is due to Histoplasma
capsulatum var. capsulatum, a dimorphic fungus. Infection occurs by inhaling spores contained
in soils contaminated by bat or bird droppings. The clinical presentation depends on the immune
status of the host and the importance of inoculum, varying from asymptomatic to disseminated
forms. AIDS patients are particularly susceptible to develop a severe disease. Antigen detection,
molecular biology techniques, and microscopic examination are used to make a rapid diagnosis.
However, antigen detection is not available in Europe and diagnosis needs a strong clinical
suspicion in non-endemic areas. Because of suggestive imagery, clinicians might focus on
tuberculosis. Our case illustrates the need for clinicians to take histoplasmosis
Researchers ; Professionals
http://hdl.handle.net/2268/214760
10.1080/17843286.2017.1376454

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