Article (Scientific journals)
Place du traitement substitutif de la menopause 1 an apres la publication des resultats de l'etude WHI (Women's Health Initiative)
Pintiaux, Axelle; Van den Brule, F.; Foidart, Jean-Michel et al.
2003In Revue Médicale de Liège, 58 (9), p. 572-5
Peer reviewed
 

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Keywords :
Hormone replacement therapy; conjugated estrogens and medroprogesterone acetate; Coronary heart disease; cerebro-vascular disease; venous thromboembolism; Breast cancer; Colorectal cancer; Osteoporosis; Dementia
Abstract :
[en] The currently reported data concerning the large WHI randomized controlled trial compare the impact of continuous combined conjugated estrogens + medroxyprogesterone acetate vs placebo in postmenopausal women. These results appear largely pessimistic. After 5.2 years of hormone replacement, an excess of coronary heart disease, cerebrovascular disease, venous thromboembolism, breast cancer incidence and extension, mild cognitive impairment and dementia is recorded. By contrast, osteoporotic fracture risk and colorectal cancer are decreased during hormone replacement. Accordingly, this hormonal treatment can no longer be recommended on a long term basis, except after extensive risk-benefit balance evaluation. It should no longer be prescribed for prevention of chronic diseases. It remains indicated during 4-5 years for relief of vasomotor symptoms, genital atrophy and, potentially, for some aspects of quality of life. HRT should probably be prescribed in minimal-effective dosages; new regimens, routes of administration, new compounds and associations should be envisaged in order to avoid cardiovascular or breast problems. However these new approaches ask for thorough validation studies.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Pintiaux, Axelle ;  Centre Hospitalier Universitaire de Liège - CHU > Gynécologie-Obstétrique CHR
Van den Brule, F.
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Gaspard, Ulysse ;  Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Language :
French
Title :
Place du traitement substitutif de la menopause 1 an apres la publication des resultats de l'etude WHI (Women's Health Initiative)
Alternative titles :
[en] Hormone Replacement Therapy One Year after the Results of the Women's Health Initiative
Publication date :
September 2003
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Hopital de Baviere, Liège, Belgium
Volume :
58
Issue :
9
Pages :
572-5
Peer reviewed :
Peer reviewed
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