Reference : Cortical excitability in chronic migraine.
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/214558
Cortical excitability in chronic migraine.
English
Coppola, Gianluca [> > > >]
Schoenen, Jean mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie]
2012
Current Pain and Headache Reports
16
1
93-100
Yes (verified by ORBi)
International
1531-3433
1534-3081
[en] A proportion of episodic migraine patients experiences a progressive increase in attack frequency leading to chronic migraine (CM). The most frequent external factor that leads to headache chronification is medication overuse. The neurobiological bases of headache chronification and of the vicious circle of medication overconsumption are not completely elucidated. More recently, the same neurophysiological methods used to study episodic migraine were applied to CM and medication-overuse headache (MOH). Studies of cortical responsivity tend overall to indicate an increase in excitability, in particular of somatosensory and visual cortices, reflected by increased amplitude of evoked responses, decreased activity of inhibitory cortical interneurons reflected in the smaller magnetic suppression of perceptual accuracy, and, at least for visual responses, an increase in habituation. In MOH, overconsumption of triptans or NSAIDs influences cortical excitability differently. Generalized central sensitization is suggested to play an important role in the pathophysiology of headache chronification.
http://hdl.handle.net/2268/214558
10.1007/s11916-011-0231-1

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Cortical Excitability in Chronic Migraine.pdfPublisher postprint255.86 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.