Reference : Resting state connectivity between default mode network and insula encodes acute migr...
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/214517
Resting state connectivity between default mode network and insula encodes acute migraine headache
English
Coppola, Gianluca mailto [Université de Roma I La Sapienza > > > >]
Di Renzo, Antonio [> >]
Tinelli, Emanuele [> >]
Di Lorenzo, Cherubino [> >]
Scapeccia, Marco [> >]
Parisi, Vincenzo [> >]
Serrao, Mariano [> >]
Evangelista, Maurizio [> >]
Ambrosini, Anna [> >]
Colonnese, Claudio [> >]
SCHOENEN, Jean mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie (CHR) >]
Pierelli, Francesco [> >]
2018
Cephalalgia
Blackwell Science
38
5
846-854
Yes (verified by ORBi)
International
0333-1024
1468-2982
Osney Mead Oxford
United Kingdom
[en] brain networks ; insula ; migraine
[en] Background: Previous functional MRI studies have revealed that ongoing clinical pain in different chronic pain syndromes is directly correlated to the connectivity strength of the resting default mode network (DMN) with the insula.
Here, we investigated seed-based resting state DMN-insula connectivity during acute migraine headaches.
Methods: Thirteen migraine without aura patients (MI) underwent 3 T MRI scans during the initial six hours of a spontaneous migraine attack, and were compared to a group of 19 healthy volunteers (HV). We evaluated headache intensity with a visual analogue scale and collected seed-based MRI resting state data in the four core regions of the DMN: Medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), and left and right inferior parietal lobules (IPLs), as well as in bilateral insula.
Results: Compared to HV, MI patients showed stronger functional connectivity between MPFC and PCC, and between MPFC and bilateral insula. During migraine attacks, the strength of MPFC-to-insula connectivity was negatively correlated with pain intensity.
Conclusion:We show that greater subjective intensity of pain during a migraine attack is associated with proportionally weaker DMN-insula connectivity. This is at variance with other chronic extra-cephalic pain disorders where the opposite was found, and may thus be a hallmark of acute migraine head pain.
http://hdl.handle.net/2268/214517
10.1177/0333102417715230

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