[en] Background: Previous functional MRI studies have revealed that ongoing clinical pain in different chronic pain syndromes is directly correlated to the connectivity strength of the resting default mode network (DMN) with the insula.
Here, we investigated seed-based resting state DMN-insula connectivity during acute migraine headaches.
Methods: Thirteen migraine without aura patients (MI) underwent 3 T MRI scans during the initial six hours of a spontaneous migraine attack, and were compared to a group of 19 healthy volunteers (HV). We evaluated headache intensity with a visual analogue scale and collected seed-based MRI resting state data in the four core regions of the DMN: Medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), and left and right inferior parietal lobules (IPLs), as well as in bilateral insula.
Results: Compared to HV, MI patients showed stronger functional connectivity between MPFC and PCC, and between MPFC and bilateral insula. During migraine attacks, the strength of MPFC-to-insula connectivity was negatively correlated with pain intensity.
Conclusion:We show that greater subjective intensity of pain during a migraine attack is associated with proportionally weaker DMN-insula connectivity. This is at variance with other chronic extra-cephalic pain disorders where the opposite was found, and may thus be a hallmark of acute migraine head pain.
Disciplines :
Neurology
Author, co-author :
Coppola, Gianluca; Université de Roma I La Sapienza
Di Renzo, Antonio
Tinelli, Emanuele
Di Lorenzo, Cherubino
Scapeccia, Marco
Parisi, Vincenzo
Serrao, Mariano
Evangelista, Maurizio
Ambrosini, Anna
Colonnese, Claudio
SCHOENEN, Jean ; Centre Hospitalier Universitaire de Liège - CHU > Service de neurologie (CHR)
Pierelli, Francesco
Language :
English
Title :
Resting state connectivity between default mode network and insula encodes acute migraine headache
Publication date :
2018
Journal title :
Cephalalgia
ISSN :
0333-1024
eISSN :
1468-2982
Publisher :
Blackwell Science, Osney Mead Oxford, United Kingdom
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