Article (Scientific journals)
Effects of protein, essential amino acids, B-Hydroxy B-Methylbutyrate, creatine, Dehydroepiandrosterone and fatty acid supplementation on muscle mass, muscle strength and physical performance in older people aged 60 years and over. A systematic review of the litterature.
Beaudart, Charlotte; Rabenda, Véronique; Simmons, Michael et al.
2018In Journal of Nutrition, Health and Aging, 22 (1), p. 117-130
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Keywords :
Activities in daily living; instrumental activities of daily living; multimorbidity; communitydwelling older adults
Abstract :
[en] Abstract: Objectives: The objective of this study was to perform a systematic review to investigate the effects protein, essential amino acids (EAA), β-hydroxy β-methylbutyrate (HMB), creatine, dehydroepiandrosterone (DHEA) and fatty acid supplementation on muscle mass, muscle strength and physical performance of elderly subjects. Methods: Using the electronic databases MEDLINE and EMBASE we identified RCTs published until February 2016 which assessed the effects of these nutrient supplementation on muscle strength, muscle mass or physical performance. Study selection and data extraction were performed by two independent reviewers. Results: Search strategy allowed us to identify 23 RCTs. Among them, four used proteins as nutritional supplement, seven EAAs, six creatine, four DHEA and finally, two HMB. From our systematic review, it seems that the effects of these supplementations on muscle health are rather limited. Only consistent effects of EAA supplementation on physical performance (3 out of the 4 RCTs using EAA supplementation found significant effect of this supplementation on physical performance) and HMB supplementation on muscle mass (all the 2 identified RCTs using HMB supplementation found significant effect of this supplementation on muscle mass) have been found across studies. No consistent effects were found for the other types of dietary supplementation. Because of the important limitations in study design, inconsistency and lack of directness, the overall quality of the evidence was judged to be low or very low using the GRADE system. Conclusion: This systematic review showed a limited effect of nutritional supplementation on muscle mass, muscle power and physical function. Inconsistent positive effects were observed for some specific supplementations but the results only concerned one aspect of the muscle. Well designed and appropriately powered RCTs are needed to provide evidence for appropriate clinical recommendations.
Disciplines :
Public health, health care sciences & services
Geriatrics
Author, co-author :
Beaudart, Charlotte ;  Université de Liège > Département des sciences de la santé publique > Epidémiologie clinique
Rabenda, Véronique ;  Université de Liège > Département des sciences de la santé publique > Epidémiologie clinique
Simmons, Michael
Geerinck, Anton ;  Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Araujo De Carvalho, Islene
Reginster, Jean-Yves  ;  Université de Liège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Amuthavalli Thiyagarajan, Jotheeswaran
Bruyère, Olivier  ;  Université de Liège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Language :
English
Title :
Effects of protein, essential amino acids, B-Hydroxy B-Methylbutyrate, creatine, Dehydroepiandrosterone and fatty acid supplementation on muscle mass, muscle strength and physical performance in older people aged 60 years and over. A systematic review of the litterature.
Publication date :
2018
Journal title :
Journal of Nutrition, Health and Aging
ISSN :
1279-7707
eISSN :
1760-4788
Publisher :
Serdi Edition, Paris, France
Volume :
22
Issue :
1
Pages :
117-130
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 14 September 2017

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