Reference : Simultaneous analysis of nucleobases, nucleosides and ginsenosides in ginseng extract...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/214022
Simultaneous analysis of nucleobases, nucleosides and ginsenosides in ginseng extracts using supercritical fluid chromatography coupled with single quadrupole mass spectrometry
English
Huang, Yang mailto [Université de Liège - ULiège > > > Doct. sc. bioméd. & pharma. (paysage)]
Zhang, Tingting [> >]
Zhao, Yumei [> >]
Zhou, Haibo [> >]
Tang, Guangyun [> >]
Fillet, Marianne mailto [Université de Liège > Département de pharmacie > Analyse des médicaments >]
Crommen, Jacques mailto [Université de Liège > Département de pharmacie > Département de pharmacie >]
Jiang, Zhengjin [> >]
29-Mar-2017
Journal of Pharmaceutical and Biomedical Analysis
144
213
Journal of Pharmaceutical and Biomedical Analysis
219
Yes (verified by ORBi)
International
0731-7085
1873-264X
[en] Ginseng extracts ; Supercritical fluid chromatography ; NucleobasesNucleosides
[en] Nucleobases, nucleosides and ginsenosides, which have a significant impact on the physiological activity of organisms, are reported to be the active components of ginseng, while they are less present in ginseng extracts. Few analytical methods have been developed so far to simultaneously analyze these three classes of compounds with different polarities present in ginseng extracts. In the present study, a simple and efficient analytical method was successfully developed for the simultaneous separation of 17 nucleobases, nucleosides and ginsenosides in ginseng extracts using supercritical fluid chromatography coupled with single quadrupole mass spectrometry (SFC-MS). The effect of various experimental factors on the separation performance, such as the column type, temperature and backpressure, the type of modifier and additive, and the concentration of make-up solvent were systematically investigated. Under the selected conditions, the developed method was successfully applied to the quality evaluation of 14 batches of ginseng extracts from different origins. The results obtained for the different batches indicate that this method could be employed for the quality assessment of ginseng extracts
Centre Interdisciplinaire de Recherche sur le Médicament - CIRM
Researchers ; Professionals ; Students ; General public
http://hdl.handle.net/2268/214022
10.1016/j.jpba.2017.03.059

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