Supercritical fluid chromatography; Traditional chinese medicines; Achiral separations
Abstract :
[en] Traditional Chinese medicines (TCMs) are gaining increasing popularity throughout the world due to their long historical clinical practices. Highly efficient analytical separation tools are essential for investigating the mysterious properties of TCMs and their quality control. Supercritical fluid chromatography (SFC) showed a great potential in TCM analysis for both nonpolar and polar components. In this paper, an overview of the experimental conditions (i.e. detection mode, stationary phase, mobile phase composition, pressure and temperature) used in SFC for achiral separations of TCM components is presented and recent applications to the analysis of different classes of compounds extracted from TCMs, such as lipids, terpene and terpenoids, phenolic compounds, flavonoids, alkaloids, saponins and carbohydrates, will be briefly described.
Research Center/Unit :
Institute of Pharmaceutical Analysis, College of Pharmacy, Jinan University, Guangzhou, 510632, China;Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine & New Drug Research, Jinan University, Guangzhou 510632, China;Laboratory for the Analysis of Medicine, Department of Pharmaceutical Sciences, CIRM, University of Liege, CHU B36, B-4000 Liege, Belgium CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Huang, Yang ; Université de Liège - ULiège > Doct. sc. bioméd. & pharma. (paysage)
Tang, Guangyun
Zhang, Tingting
Fillet, Marianne ; Université de Liège > Département de pharmacie > Analyse des médicaments
Crommen, Jacques ; Université de Liège > Département de pharmacie > Analyse des Médicaments
Jiang, Zhengjin; Jinan University > Pharmacy > Analytical Chemistry
Language :
English
Title :
Supercritical Fluid Chromatography in Traditional Chinese Medicine Analysis
Publication date :
2018
Journal title :
Journal of Pharmaceutical and Biomedical Analysis
ISSN :
0731-7085
eISSN :
1873-264X
Publisher :
Elsevier, Amsterdam, Netherlands
Volume :
147
Pages :
65-80
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Guangzhou Science and Technology Plan Application Foundation, Guangdong Province, China (2014J4100120), and the Science and Technology Planning Project of Guangdong Province, China (2015A020211018).
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