Importance of Metabolism Variations in a Model of Extracorporeal Carbon Dioxide Removal

[en] Extracorporeal CO2 Removal device is used in clinics when a patient suffers from a pulmonary insufficiency like Acute Respiratory Distress Syndrome and allows to decarboxylate blood externally. In this work, a model of the respiratory system coupled with such a device is proposed to analyze the decrease of CO2 partial pressure in blood. To validate the model, some parameters are estimated thanks to experimental data. Metabolism is a crucial parameter and we show that its time evolution must be taken into account in order to have correct CO2 partial pressure simulations in arteries and in veins.

Research Center/Unit :

Giga-In silice medicine

Disciplines :

Engineering, computing & technology: Multidisciplinary, general & others

Author, co-author :

Habran, Simon ; Université de Liège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles

Desaive, Thomas ; Université de Liège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles

MORIMONT, Philippe ; Centre Hospitalier Universitaire de Liège - CHU > Frais communs médecine - Pool assistants

LAMBERMONT, Bernard ; Centre Hospitalier Universitaire de Liège - CHU > Frais communs médecine - Pool assistants

Dauby, Pierre ; Université de Liège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles

Language :

English

Title :

Importance of Metabolism Variations in a Model of Extracorporeal Carbon Dioxide Removal

Publication date :

2016

Event name :

The 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

Event organizer :

IEEE-EMBS

Event place :

Orlando, United States

Event date :

du 16 août 2016 au 20 août 2016

Audience :

International

Journal title :

Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society

ISSN :

1557-170X

Publisher :

IEEE Service Center, Piscataway, United States - New Jersey

Peer reviewed :

Peer reviewed

Additional URL :

http://ieeexplore.ieee.org/abstract/document/7591669/?reload=true

Name of the research project :

Mathematical modeling and optimization of the use of cardiopulmonary assistances in intensive care units

Available on ORBi :

since 31 August 2017

Statistics

Number of views

132 (13 by ULiège)

Number of downloads

249 (10 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

M. Ragaller and T. Richter, "Acute lung injury and acute respiratory distress syndrome," Journal of Emergencies, Trauma and Shock, vol. 3(1), pp. 43-51, 2010
T.B. Enger, A. Philipp, et al., "Prediction of mortality in adult patients with severe acute lung failure receiving veno-venous extracorporeal membrane oxygenation: a prospective observational study," Critical Care, vol. 18(2), pp. R67, 2014
S. Klinzing, U. Wenger, et al., "External validation of scores proposed for estimation of survival probability of patients with severe adult respiratory distress syndrome undergoing extracorporeal membrane oxygenation therapy: a retrospective study," Critical Care, vol. 19(1), pp. 142, 2015
I. Vadasz, R.D. Hubmayr, et al., " Hypercapnia: A Nonpermissive Environment for the Lung," American Journal of Respiratory Cell and Molecular Biology, vol. 46(4), pp. 417-421, 2012
X. Represse, C. Charron and A. Vieillard-Baron, " Right ventricular failure in acute lung injury and acute respiratory distress syndrome," Minerva anestesiologica, vol. 78(8), pp. 941, 2012
X. Represse, C. Charron and A. Vieillard-Baron, " Une approche moderne de la ventilation dans le syndrome de détresse respiratoire aiguë: laissez le ventricule droit respirer !," Réanimation, vol. 23(2), pp. 366-371, 2014
N. Ferguson, E. Fan, et al.," The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material," Intensive Care Med, vol. 38(10), pp. 1573-1582, 2012
J. J. Batzel, F. Kappel, et al., " Cardiovascular and respiratory systems: modeling, analysis, and control" in SIAM, vol. 34, 2007
D. S. Karbing, S. Kjaergaardand, et al.," Minimal model quantification of pulmonary gas exchange in intensive care patients," Med Eng Phys, vol. 33(2), pp. 240-248, 2011
M. J. Murray and D. Cook, " Cardiopulmonary Bypass: Principles and Practice (chapter 33)," in LIPPINCOTT WILLIAMS & WILKINS, a Wolters Kluwer business, 3rd edition, 2008
S.E. Rees, S. Kjærgaard, et al.," The Automatic Lung Parameter Estimator (ALPE) system: Non-invasive estimation of pulmonary gas exchange parameters in 10-15 minutes," Journal of clinical monitoring and computing, vol. 17(1), pp. 43-52, 2002
M. Walter, S. Weyer, et al.," A physiological model for extracorporeal oxygenation controller design," Conf Proc IEEE Eng Med Biol Soc, pp. 434-437, 2010
O.A. Linares, W.E. Schiesser et al., "In silico ordinary differential equation/partial differential equation hemodialysis model estimates methadone removal during dialysis," Journal of pain research, vol. 8, pp. 417, 2015
F.S. Grodins, J. Buell and A.J. Bart," Mathematical analysis and digital simulation of the respiratory control system," DTIC Document, 1967
TJ Trueb, NS Cherniack, et al.," A mathematical model of the controlled plant of the respiratory system," Biophysical journal, vol. 11(10), pp. 810-834, 1971
S.T. Hinski, " Respiratory care clinical competency LAB MANUAL (chapter 23)," in ELSEVIER, 2014
C. Karagiannidis, K.A. Kampe et al.," Veno-venous extracorporeal CO2 removal for the treatment of severe respiratory acidosis: pathophysiological and technical considerations," Critical care, vol. 18(3), pp. 124, 2014.