Reference : Umbilical Cord Blood Cytomegalovirus Serostatus Does Not Have an Impact on Outcomes o...
Scientific journals : Article
Human health sciences : Hematology
http://hdl.handle.net/2268/213868
Umbilical Cord Blood Cytomegalovirus Serostatus Does Not Have an Impact on Outcomes of Umbilical Cord Blood Transplantation for Acute Leukemia
English
Nikolajeva, Olga mailto [Anthony Nolan Research Institute > > > >]
Rocha, Vanderson [Churchill Hospital, University of Oxford > Department of Haematology > > >]
Danby, Robert [Anthony Nolan Research Institute > > > >]
Ruggeri, Annalisa [Eurocord, Hopital Saint Louis > > > >]
Volt, Fernanda [Eurocord, Hopital Saint Louis > > > >]
BAUDOUX, Etienne mailto [Centre Hospitalier Universitaire de Liège - CHU > > Thérapie cellulaire >]
Gomez, Susana G [Banc de Sang, Teixits, Barcelona > > > >]
Kögler, Gesine [Dusseldorf Cord Blood Bank > > > >]
Larghero, Jerome [Hôpital Saint-Louis, Unité de Thérapie Cellulaire > > > >]
Lecchi, Lucilla [Centre of Transfusion Medicine, Cellular Therapy and Cryobiology > > > >]
Sanchez Martinez, Mar [Banc de Sang, Teixits, Barcelona > > > >]
Navarrete, Cristina [NHS Cord Blood Bank, NHS Blood and Transplant > > > >]
Pouthier, Fabienne [Besançon Cord Blood Bank of the Etablissement Français du Sang, > > > >]
Querol, Sergio [Banc de Sang, Teixits, Barcelona > > > >]
Kenzey, Chantal [Eurocord, Hopital Saint Louis > > > >]
Szydlo, Richard [Imperial College London > > > >]
Gluckman, Eliane [Eurocord, Hopital Saint Louis > > > >]
Madrigal, Alejandro [Anthony Nolan Research Institute > > > >]
2017
Biology of Blood and Marrow Transplantation
Yes
International
[en] Umbilical cord blood transplantation ; Cytomegalovirus ; Acute leukemia
[en] Several studies have reported an impact of adult hematopoietic stem cell donor cytomegalovirus (CMV) serostatus on allogeneic hematopoietic cell transplantation outcomes. Limited data, however, are available on the impact of cord blood unit (CBU) CMV serostatus on allogeneic umbilical cord blood transplantation (UCBT) outcomes. We analyzed, retrospectively, the impact of CBU CMV serostatus on relapse incidence (RI) and 2-year nonrelapse mortality (NRM) of single-unit CBU transplantation for acute leukemia. Data from 1177 de novo acute leukemia pediatric and adult patients transplanted within European Group for Blood and Marrow Transplantation centers between 2000 and 2012 were analyzed. CBUs were provided by the European Cord Blood Banks. The median follow-up time for live patients was 59.9 months. The recipients of CMV-seropositive and -seronegative CBUs showed a comparable RI (33% versus 35%, respectively, P = .6) and 2-year cumulative incidence of NRM (31% versus 32%, respectively, P = .5). We conclude that CBU CMV serostatus did not influence RI and NRM in de novo acute leukemia patients after allo-UCBT and should not be included as a criteria for cord blood choice.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/213868
10.1016/j.bbmt.2017.06.022

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