Article (Scientific journals)
Whole-body computed tomography versus conventional skeletal survey in patients with multiple myeloma: a study of the International Myeloma Working Group.
Hillengass, J.; Moulopoulos, L. A.; Delorme, S. et al.
2017In Blood Cancer Journal, 7 (8), p. 599
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Abstract :
[en] For decades, conventional skeletal survey (CSS) has been the standard imaging technique for multiple myeloma (MM). However, recently whole-body computed tomography (WBCT) has been implemented into the diagnostic criteria of MM. This analysis compares sensitivity and prognostic significance of WBCT and CSS in patients with smoldering MM (SMM) and MM. Fifty-four of 212 patients (25.5%) had a negative CSS and a positive WBCT for osteolytic lesions (P<0.0001). Of 66 patients with SMM based on CSS, 12 (22.2%) had osteolytic lesions on WBCT. In comparison, WBCT failed to detect some bone destructions in the appendicular skeleton possibly due to limitations of the field of view. Presence of lytic bone lesions in WBCT was of borderline prognostic significance (P=0.051) for SMM patients, with a median time to progression of 38 versus 82 months for those without bone destructions. In conclusion, WBCT identifies significantly more sites of bone destruction than CSS. More than 20% of patients with SMM according to CSS have in fact active MM detectable with WBCT. On the basis of this and other studies, WBCT (either computed tomography (CT) alone or as part of a positron emission tomography-CT protocol) should be considered the current standard for the detection of osteolytic lesions in MM.
Disciplines :
Hematology
Author, co-author :
Hillengass, J.
Moulopoulos, L. A.
Delorme, S.
Koutoulidis, V.
Mosebach, J.
Hielscher, T.
Drake, M.
Rajkumar, S. V.
Oestergaard, B.
Abildgaard, N.
Hinge, M.
Plesner, T.
Suehara, Y.
Matsue, K.
Waage, A.
Goldschmidt, H.
Dimopoulos, M. A.
Lentzsch, S.
Durie, B.
Terpos, E.
WITHOFS, Nadia ;  Centre Hospitalier Universitaire de Liège - CHU > Service médical de médecine nucléaire et imagerie onco
CAERS, Jo  ;  Centre Hospitalier Universitaire de Liège - CHU > Service d'hématologie clinique
More authors (12 more) Less
Language :
English
Title :
Whole-body computed tomography versus conventional skeletal survey in patients with multiple myeloma: a study of the International Myeloma Working Group.
Publication date :
2017
Journal title :
Blood Cancer Journal
eISSN :
2044-5385
Publisher :
Nature Publishing Group, United States - New York
Volume :
7
Issue :
8
Pages :
e599
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 28 August 2017

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