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Non-pathological aging of the executive functions: influence of the Val108/158Met nucleotide polymorphism of the COMT gene
Gilsoul, Jessica; Manard, Marine; Collette, Fabienne
201715th European Congress of Psychology
 

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Keywords :
Executive functions; Aging; Dopamine
Abstract :
[en] Objectives. The aim of the study is to investigate the influence of the COMT Val108/158Met nucleotide polymorphism, associated with dopaminergic regulation, on executive functions in normal aging. Indeed, according to the Dual-State Theory, Val/Val polymorphism of the COMT gene would favor better flexibility abilities, whereas Met/Met carriers would favor better stability abilities. These genotypic effects should be magnified in older people, as a decrease in cognitive resources increases the influence of individual genetic differences on cognitive performance. Method. We assessed the executive processes of inhibition, shifting, and updating – thanks to many different tasks in groups of young (n = 55) and aged participants (n = 45) carrying one of the three polymorphism of the COMT gene (Val/Val, Val/Met, Met/Met). T-tests between our two groups (Young versus Aged) but also a 6 (Group: Young-Met/Met, Young-Val/Met, Young- Val/Val, Old-Met/Met, Old-Val/Met, and Old-Val/Val) X 3 (Executive functioning: Inhibition, Shifting, and Updating) repeated measure ANOVA with Executive functioning as within-subject factor (p < .05) were carried out. Results. Young and old participants significantly differed on the three executive functions. The comparison of genotypic groups showed no significant differences in young or older participants respectively. Interestingly, the Old-Val/Val group showed a lower performance than the young one on inhibition tasks. Conclusion. As expected, we found an age effect on all the executive functions. The significant difference between the Young-Val/Val and the Old-Val/Val groups on inhibition suggests an age-related decrease in abilities requiring a stability component in individuals possessing a less favoring genotype for this component.
Research center :
GIGA-CRC in Vivo Imaging
Disciplines :
Neurosciences & behavior
Author, co-author :
Gilsoul, Jessica ;  Université de Liège > Département de Psychologie > GIGA-CRC in Vivo Imaging
Manard, Marine ;  Université de Liège > Département de Psychologie > GIGA-CRC in Vivo Imaging
Collette, Fabienne  ;  Université de Liège > Département de Psychologie > Neuropsychologie
Language :
English
Title :
Non-pathological aging of the executive functions: influence of the Val108/158Met nucleotide polymorphism of the COMT gene
Alternative titles :
[fr] Vieillissement non pathologique des fonctions exécutives: influence du polymorphisme nucléotidique Val108/158Met du gène COMT.
Publication date :
13 July 2017
Number of pages :
A0
Event name :
15th European Congress of Psychology
Event organizer :
Prof. Dr. Pim Cuijpers
Event place :
Amsterdam, Netherlands
Event date :
11-14 July 2017
Audience :
International
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Commentary :
Best Poster Award
Available on ORBi :
since 18 August 2017

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