Article (Scientific journals)
Evaluation of the effect of oral omeprazole on canine cerebrospinal fluid production: A pilot study.
Girod, Maud; Allerton, F.; Gommeren, Kris et al.
2016In Veterinary Journal, 209, p. 119-24
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Keywords :
Administration, Oral; Animals; Anti-Ulcer Agents/adverse effects; Biomarkers/blood; Cerebrospinal Fluid/drug effects/secretion; Dogs/cerebrospinal fluid; Electrophoresis/veterinary; Female; Male; Nephelometry and Turbidimetry/veterinary; Omeprazole/adverse effects; Pilot Projects; Proton Pump Inhibitors/adverse effects; Serum Albumin/analysis; Albumin quotient; Cerebrospinal fluid production; High-resolution electrophoresis; Nephelometry; Omeprazole
Abstract :
[en] Administration of omeprazole by ventriculo-cisternal perfusion or intravenously has been shown to decrease cerebrospinal fluid (CSF) production in dogs and rabbits. Oral omeprazole has consequently been recommended to reduce CSF production in dogs with conditions in which clinical signs may be attributable to an accumulation of CSF in the central nervous system (e.g. hydrocephalus, syringomyelia). The albumin quotient (QAlb), the ratio between CSF and serum albumin concentration, has been proposed as a reliable means to evaluate CSF production; decreasing CSF production should cause an increase in QAlb. The aims of this study were to assess the effect of oral administration of omeprazole on QAlb in dogs and to compare two methods to assess CSF albumin concentration. Fifteen healthy Beagle dogs received omeprazole (1.2 mg/kg/day) orally for 14 days; CSF and blood were obtained before and after treatment. CSF albumin concentrations were evaluated by nephelometry and high-resolution protein electrophoresis. Regardless of the method used for measuring albumin, QAlb did not change significantly following oral omeprazole administration, suggesting that CSF production in healthy dogs may not be affected by chronic oral therapy with omeprazole.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Girod, Maud ;  Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Pathologie médicale des petits animaux
Allerton, F.
Gommeren, Kris  ;  Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Pathologie médicale des petits animaux
Tutunaru, Alexandru-Cosmin ;  Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Anesthésiologie gén. et pathologie chirurg. des grds animaux
de Marchin, J.
Van Soens, Iris ;  Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Pathologie médicale des petits animaux
Ramery, Eve ;  Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Biochimie médicale
Peeters, Dominique ;  Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Médecine interne des animaux de compagnie
Language :
English
Title :
Evaluation of the effect of oral omeprazole on canine cerebrospinal fluid production: A pilot study.
Publication date :
2016
Journal title :
Veterinary Journal
ISSN :
1090-0233
eISSN :
1532-2971
Publisher :
Elsevier, London, United Kingdom
Volume :
209
Pages :
119-24
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2016 Elsevier Ltd. All rights reserved.
Available on ORBi :
since 06 August 2017

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