[en] Escherichia coli lipopolysaccharide (3 µg/kg) injection intravenously to rats (n=23) is accompanied with development of polyphasic fever and shift of nociceptive reactions threshold to hypo- or hyperalgesia according to fever phase. The blockade of afferent and efferent signals after vagotomy disturbs formation of fever and nociceptive reactions pattern. Therefore, obtained data allow explaining the phenomenon of nociceptive reactions and fever threshold shift after imperative change of signals flow through vagus nerve (for example, during qigong practicing)