Trypanosomiasis challenge estimation using the diminazene aceturate (Berenil) index in Zebu in Gabon.

[en] A longitudinal study was conducted within a cattle ranch in Gabon to determine the diminazene aceturate (Berenil) index (DAI) in a group of Zebu, raised under low tsetse density; this measure providing an assessment of trypanosomiasis risk. The objective was to evaluate the trypanosomiasis pressure thus informing trypanosomiasis control methods and cattle management. Twenty female adult Zebu were monitored for 24 weeks during the dry season. Blood samples were collected on aweekly basis and subjected to parasitological and haematological analysis (n = 480), using the buffy-coat method and the packed cell volume value (PCV), respectively, infected animals were treated with a single intramuscular injection of diminazene aceturate (8 mg/kg). Twenty-nine single infectious events were recorded and a DAI of 1.45 was calculated. Two trypanosome species were identified: Trypanosoma congolense (96.2%) and Trypanosoma vivax (3.8%). The mean PCV value of the infected animals was lower (26.6) compared to non-infected animals (32.0). This study shows that DAI may be a useful tool to assess trypanosomiasis. However, this is a time-consumingmethod that may be improved by using randomly selected sentinel animals to adapt the chemoprophylactic schemes, hence decreasing the costs and the drug resistance risk.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

COSSIC, Brieuc; University of Edinburgh, > Edinburgh Medical School: Biomedical Sciences, > Biomedical Sciences, > 2017

ADJAHOUTONON, B

GLOAGUEN, P

DIBANGANGA, GL

MAGANGA, G

Leroy, Pascal ; Université de Liège > Département des productions animales (DPA) > Conseillers du Recteur

Picozzi, K

Language :

English

Title :

Trypanosomiasis challenge estimation using the diminazene aceturate (Berenil) index in Zebu in Gabon.

Publication date :

March 2017

Journal title :

Tropical Animal Health and Production

ISSN :

0049-4747

eISSN :

1573-7438

Publisher :

Kluwer Academic Publishers, Boston, United States - Massachusetts

Volume :

Issue :

Pages :

619-624

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 03 August 2017

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Bibliography

Bengaly A., Sidibe I., Ganaba R., Desquesnes M., Boly H., Sawadogo L., 2002. Comparative pathogenicity of three genetically distinct types of Trypanosoma congolense in cattle: clinical observations and haematological changes. Veterinary Parasitology, 108(1), 1-19.
Bhamla M.S., Benson B., Chai C., Katsikis G., Johri A., Prakash M., 2017. Hand-powered ultralow-cost paper centrifuge. Nature Biomedical Engineering 1, 0009. doi:10.1038/s41551-016-000.
Blood D.C., Radostits O.M., Gay C.C., Hinchcliff K.W., Constable P.D., 2007. Veterinary Medicine: A textbook of the Diseases of Cattle, Horses, Sheeps, Pigs and Goats. Tenth ed. Saunders Ltd, 2065pp.
Claxton, R.R., Leperre P., Rawlings P., Snow W.F., Dwinger R.H., 1991. Trypanosomiasis challenge estimation in The Gambia using the Berenil index: Comparison between Zebu and N’Dama. ILRI, OAU/STRC Publication; 115.
Cybulski J.S., Clements J., Prakash M., 2014. Foldscope: Origami-based paper microscope. PLOS One 9(6), e98781. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098781 accessed 22nd July 2016
De La Rocque S., Michel J.F., Cuisance D., De Wispelaere G., Solano P., Augusseau X., Arnaud M., Guillobez S., 2001. Du satellite au microsatellite. Le risque trypanosomien. Une approche globale pour une decision locale. Montpellier: CIRAD, 151p.
Desquesnes M., 2004. Livestock Trypanosomes and their Vectors in Latin America. OIE and CIRAD. Paris, France 192pp.
Dia L.M., Desquesnes M., 2007. Fiche N°3, Les trypanosomes animals, utilisation rationnelle des trypanocides. CIRAD, Santé Animale en Afrique de l’Ouest, recommandations techniques, 7pp.
Gall Y., Woitag T., Bauer B., Sidibe I., McDermott J., Mehlitz D., Clausen P.H., 2004. Trypanocidal failure suggested by PCR results in cattle field samples. Acta Tropica, 92, 7-16.
Gummow B., Swan G.E., Du Preez J.L., Verwoerd D.W., 1994. A bioequivalence and pharmacokinetic evaluation of two commercial diminazene aceturate formulations administered intramuscularly to cattle. Onderstepoort Journal of Veterinary Research, 61, 317-326.
Kaur G., Chaudhary R.K., Srivastava A.K., 2000. Pharmacokinetics, urinary excretion and dosage regimen of Diminazen in crossbred calves. Acta Veterinaria Hungarica 48(2), 187-192.
Kellner H.M., Eckert H.G., Volz M.H., 1985. Studies in cattle on the disposition of the anti-trypanosomal drug diminazene diacturate (Berenil). Tropical Medicine and Parasitology, 36(4), 199-204.
Kristjanson P.M., Swallow B.M., Rowlands G.J., Kruska R.L., de Leeuw P.N., 1999. Measuring the costs of African animal trypanosomosis, the potential benefits of control and returns to research. Agricultural Systems, 59, 79-98.
Leak S.G., Colardelle C., D’Ieteren G., Dumont P., Feron A., Jeannin P., Minengu M., Mulungu M., Ngamuna S., Ordner G., Sauveroche B., Trail J.C.M., Yangari G., 1991. Glossina fusca group Tsetse as vectors of cattle trypanosomiasis in Gabon and Zaire. Medical and Veterinary Entomology, 5(1), 111-20.
Leak S.G.A., 1999. Tsetse Biology and Ecology: Their Role in the Epidemiology and Control of Trypanosomosis. ILRI, CABI Publishing, 568pp
Marcotty T., Simukoko H., Berkvens D., Vercruysse J., Praet N., Van den Bossche P., 2008. Evaluating the use of packed cell volume as an indicator of trypanosomal infections in cattle in eastern Zambia. Preventive Veterinary Medicine, 87, 288-300.
Maganga G.D., Moussadji K., N’Dilimabaka N., Mve-Ondo B., Mombo I.M., Cossic B., Mikala Okouyi C.S., Souza A., Agossou E., Kumulungi B., Mavoungou J.F., Leroy E.M., Ollomo B., 2016. Molecular study of trypanosomes infecting trypanotolerant cattle in livestock from the south of Gabon. Submitted to Parasitology Research.
Marx V., 2015. PCR heads into the field. Nature methods, 12, 393-397.
Merlin P., 1986. Normes hématologiques du Zébu Gudali dans les hauts plateaux du Nord-Ouest camerounais. Revue d’élevage et médecine vétérinaire des pays tropicaux, Vol 39, 3-4, 403-407.
Mungube E.O., Vitouley H.S., Allegye-Cudjoe E., Diall O., Boucoum Z., Diarra B., Sanogo Y., Randolph T., Bauer B., Zessin K.H., Clausen P.H., 2012. Detection of multiple drug-resistance Trypanosoma congolense populations in village cattle of south-east Mali. Parasites and Vectors, 5, 155. https://parasitesandvectors.biomedcentral.com/articles/10.1186/1756-3305-5-155 accessed 15th August 2016.
Murray, M., 1977. An improved parasitological technique for the diagnosis of African trypanosomiasis. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 71(4), 325-6.
Murray M., Stear M.J., Trail J.C.M., D’Ieteren G.D.M, Agyemang K., Dwinger R.H., 1991. Trypanosomiasis in cattle: prospects for control. Breeding for disease resistance in farm animals. Ed. By Owen J.B. and Axford R.F.E., CAB International, Wallingford UK, 499 p.
OIE, 2013. Terrestrial Manual, Chapter 2.4.18 Trypanosomiasis (Tsetse-transmitted).
Ordner G., Colardelle C., d’Ieteren C.D.M., Dumont P., Itty P., Jeannin P., Leak S.G.A., Maehl J.H.H., Nagda S.M., Paling R.W., Rarieya J.M., Thorpe W., Trail J.C.M., Yangari G., 1988. Health and productivity of trypanotolerant and susceptible cattle exposed to trypanosomiasis in Gabon and the impact of strategic chemoprophylaxis. Chap 31 in. The African trypanotolerant livestock network, Livestock Production in Tsetse affected areas of Africa. ILCA/ILRAD, English press, Nairobi, Kenya.
Picozzi K., Tilley A., Fevre E.M., Coleman P.G., Magona J.W., Odiit, M. Eisler, M. Welburn, S., 2002. The diagnosis of trypanosome infections: Applications of novel technology for reducing disease risk. African Journal of Biotechnology, 1, 39-45.
Shaw A.P.M., 2009. Assessing the economics of animal trypanosomosis in Africa – history and current perspectives. Onderstepoort Journal of Veterinary Research, 76, 27-32.
Swallow B.M., 2000 Impacts of trypanosomiasis on African agriculture. PAAT Technical Scientific Series 2, FAO.
Takken W., Taylor-Lewis E.G., Woodford M.H., 1988. Field studies on animal trypanosomiasis in Mozambique. I. Effectiveness of the prophylactic drug isometamidium chloride and pyrithidium bromide. Tropical Animal Health and Production, 20(4), 243-55
Trail, J.C.M., d’Ieteren G.D.M., Colardelle C., Maille J.C., Ordner G., Sauveroche B., Yangari G.,1990. Evaluation of a field test for trypanotolerance in young N’Dama cattle. Acta Tropica, 48, 47-57.
Traore M., 1989. Etude de la productivité du bétail N’Dama élevé en ranching et dans les troupeaux traditionnels du cercle de Yanfolila (Mali) –perspectives d’amélioration. Thèse Doctorat d’Etat ès Science Naturelles. IEMVT-CIRAD, France, 314 pp.
Uilenberg G., 1998. A field guide for the diagnosis treatment and prevention of African animal trypanosomosis. FAO Rome, 158 pp.
Whiteside E.F., 1962. Interactions between drugs, trypanosomes and cattle in the field. In: Drugs, Parasites and Hosts (eds., Goodwin L.G. and Nimmo-Smith R.H.) Churchill, London, England, p.116-141.
Woo, P. T. K., 1970. The haematocrit centrifuge technique for the diagnosis of African trypanosomiasis. Acta tropica, 27(4), 384-386.