Article (Scientific journals)
Capsaicin-sensitive area in the ventral surface of the rat medulla.
Koulchitsky, Stanislav; Azev, O. A.; Gourine, A. V. et al.
1994In Neuroscience Letters, 182 (2), p. 129-32
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Keywords :
drug effects; Blood Pressure/drug effects; Capsaicin; Heart Rate/drug effects; pharmacology; Medulla Oblongata/physiology/ultrastructure; NADPH Dehydrogenase; Rats; Staining and Labeling
Abstract :
[en] In acute experiments on nembutal-urethan-anesthetized rats, structures selectively sensitive to capsaicin were found near the ventral surface of the medulla at the exit of hypoglossal nerve roots. Microinjection of 5-50 nl 0.01% capsaicin to the rostral region of the capsaicin-sensitive area mostly activated respiration, arterial pressure and heart rate (HR) while that to the caudal region inhibited arterial pressure and HR. In chronic experiments on rats, injection of 25 nl 1% capsaicin to the caudal capsaicin-sensitive area led to a decrease in arterial pressure by 35-45% and in HR by 10-15% within a week after operation. Arterial pressure and HR virtually reached the control level and the rostral and caudal ventral medulla showed asymmetric distribution of nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d)-positive cells by the end of the 2nd week. It is suggested that nitric oxide may be involved in the mechanisms of neurochemical rearrangements in the brainstem after application of capsaicin to the caudal ventrolateral medulla (CVLM).
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Koulchitsky, Stanislav ;  Université de Liège > Département des sciences biomédicales et précliniques > Pharmacologie
Azev, O. A.
Gourine, A. V.
Kulchitsky, V. A.
Language :
English
Title :
Capsaicin-sensitive area in the ventral surface of the rat medulla.
Publication date :
1994
Journal title :
Neuroscience Letters
ISSN :
0304-3940
eISSN :
1872-7972
Publisher :
Elsevier, Netherlands
Volume :
182
Issue :
2
Pages :
129-32
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 02 August 2017

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