Article (Scientific journals)
Does selective destruction of the vagal afferent inflow facilitate or reduce the development of fever?
Koulchitsky, Stanislav
2000In Journal of Thermal Biology, 25 (1), p. 39-43
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Keywords :
Fever; Vagus; Nociception
Abstract :
[en] Secondary afferent neurons in the (i) rostral commissural nucleus tractus solitarii (NTS) or (ii) caudal NTS in rats were destroyed with kainate. Lipopolysaccharide (3 mg/kg i.p.) in (i) led to a rise in colonic temperature (Tc) and random changes in the tail-flick reflex (TFR) latency. In (ii), lipopolysaccharide was not accompanied by fever, but induced a sustained hypoalgesia. In subdiaphragmatically vagotomized rats (iii) lipopolysaccharide failed to change Tc and TFR. Structural alterations in NTS and other brainstem nuclei in (iii) were electron microscopically visualized. The changes in the responses to lipopolysaccharide in the three groups may be related to degenerative events in the brainstem nuclei.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Koulchitsky, Stanislav ;  Université de Liège > Département des sciences biomédicales et précliniques > Pharmacologie
Language :
English
Title :
Does selective destruction of the vagal afferent inflow facilitate or reduce the development of fever?
Publication date :
2000
Journal title :
Journal of Thermal Biology
ISSN :
0306-4565
Publisher :
Pergamon
Volume :
25
Issue :
1
Pages :
39-43
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 02 August 2017

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