Effect of pressure support ventilation during weaning on ventilation and oxygenation indices in healthy horses recovering from general anesthesia.

Ida, Keila; Fantoni, Denise T.; Souto, Maria T. M. R.; Otsuki, Denise A.; Zoppa, Andre L. V.; Silva, Luis C. L. C.; Ambrosio, Aline M.

doi:10.1111/vaa.12041

Article (Scientific journals)

Effect of pressure support ventilation during weaning on ventilation and oxygenation indices in healthy horses recovering from general anesthesia.

Ida, Keila; Fantoni, Denise T.; Souto, Maria T. M. R. et al.

2013 • In Veterinary Anaesthesia and Analgesia, 40 (4), p. 339-50

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/213058

DOI
10.1111/vaa.12041

PubMed
23601289

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Keywords :

Anesthesia Recovery Period; Anesthesia, General/veterinary; Animals; Horses/physiology; Oxygen/blood; Respiration; Respiration, Artificial/methods/veterinary

Abstract :

[en] OBJECTIVE: To determine if pressure support ventilation (PSV) weaning from general anesthesia affects ventilation or oxygenation in horses. STUDY DESIGN: Prospective randomized clinical study. ANIMALS: Twenty client-owned healthy horses aged 5 +/- 2 years, weighing 456 +/- 90 kg. METHODS: In the control group (CG; n = 10) weaning was performed by a gradual decrease in respiratory rate (fR ) and in the PSV group (PSVG; n = 10) by a gradual decrease in fR with PSV. The effect of weaning was considered suboptimal if PaCO2 > 50 mmHg, arterial pH < 7.35 plus PaCO2 > 50 mmHg or PaO2 < 60 mmHg were observed at any time after disconnection from the ventilator until 30 minutes after the horse stood. Threshold values for each index were established and the predictive power of these values was tested. RESULTS: Pressure support ventilation group (PSVG) had (mean +/- SD) pH 7.36 +/- 0.02 and PaCO2 41 +/- 3 mmHg at weaning and the average lowest PaO2 69 +/- 6 mmHg was observed 15 minutes post weaning. The CG had pH 7.32 +/- 0.02 and PaCO2 57 +/- 6 mmHg at weaning and the average lowest PaO2 48 +/- 5 mmHg at 15 minutes post weaning. No accuracy in predicting weaning effect was observed for fR (p = 0.3474), minute volume (p = 0.1153), SaO2 (p = 0.1737) and PaO2 /PAO2 (p = 0.1529). A high accuracy in predicting an optimal effect of weaning was observed for VT > 10 L (p = 0.0001), fR /VT ratio </= 0.60 breaths minute(-1) L(-1) (p = 0.0001), VT /bodyweight > 18.5 mL kg(-1) (p = 0.0001) and PaO2 /FiO2 > 298 (p = 0.0002) at weaning. A high accuracy in predicting a suboptimal effect of weaning was observed for VT < 10 L (p = 0.0001), fR /VT ratio >/= 0.60 breaths minute(-1) L(-1) (p = 0.0001) and Pe'CO2 >/= 38 mmHg (p = 0.0001) at weaning. CONCLUSIONS AND CLINICAL RELEVANCE: Pressure support ventilation (PSV) weaning had a better respiratory outcome. A higher VT , VT /body weight, PaO2 /FiO2 ratio and a lower fR /VT ratio and Pe'CO2 were accurate in predicting the effect of weaning in healthy horses recovering from general anesthesia.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Ida, Keila ; Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Anesthésiologie et réanimation vétérinaires

Fantoni, Denise T.

Souto, Maria T. M. R.

Otsuki, Denise A.

Zoppa, Andre L. V.

Silva, Luis C. L. C.

Ambrosio, Aline M.

Language :

English

Title :

Effect of pressure support ventilation during weaning on ventilation and oxygenation indices in healthy horses recovering from general anesthesia.

Publication date :

2013

Journal title :

Veterinary Anaesthesia and Analgesia

ISSN :

1467-2987

eISSN :

1467-2995

Publisher :

Elsevier, New York, United States - New York

Volume :

Issue :

Pages :

339-50

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 19 July 2017

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Bibliography

Bechara JN, Fantoni DT, Barros PSM et al. (2004) Comparative study between spontaneous ventilation, intermittent positive pressure ventilation and pressure controlled ventilation in horses. Evaluation of ventilator parameters. Ars Veterinaria 12, 36-43.
Brochard L, Pluskwa F, Lemaire F (1987) Improved efficacy of spontaneous breathing with inspiratory pressure support. Am Rev Respir Dis 136, 411-415.
Cabello B, Thille AW, Roche-Campo F et al. (2010) Physiological comparison of three spontaneous breathing trials in difficult-to-wean patients. Intensive Care Med 36, 1171-1179.
Cuvelliez SG, Eicker SW, McLauchlan C et al. (1990) Cardiovascular and respiratory effects of inspired oxygen fraction in halothane-anesthetized horses. Am J Vet Res 51, 1226-1231.
Drummheller OJ (2012) Cardiopulmonary anatomy and physiology. In: Foundations of Respiratory Care, Wyka K, Clark W, Matthews P (eds). Delmar Cengage Learning, Clifton Park, NY. pp. 116-170.
Esteban A, Alia I, Ibanez J et al. (1994) Modes of mechanical ventilation and weaning. A national survey of Spanish hospitals. The Spanish Lung Failure Collaborative Group. Chest 106, 1188-1193.
Ezingeard E, Diconne E, Guyomarc'h S et al. (2006) Weaning from mechanical ventilation with pressure support in patients failing a T-tube trial of spontaneous breathing. Intensive Care Med 32, 165-169.
Fantoni DT, Alvarenga J, Silva LCLC et al. (1998) Controlled mechanical ventilation in horses under vecuronium blockage. Braz J Vet Res Anim Sci 35, 182-187.
Hopster K, Kastner SB, Rohn K et al. (2011) Intermittent positive pressure ventilation with constant positive end-expiratory pressure and alveolar recruitment manoeuvre during inhalation anaesthesia in horses undergoing surgery for colic, and its influence on the early recovery period. Veterinary Anaesth Analg 38, 169-177.
Hubbell JA, Aarnes TK, Bednarski RM et al. (2011) Effect of 50% and maximal inspired oxygen concentrations on respiratory variables in isoflurane-anesthetized horses. BMC Vet Res 7, 23.
Klemm M, Alvarenga J, Fantoni DT et al. (1998) Compared study on the effects of mechanical controlled ventilation (CMV) with or without the use of positive-end-expiratory-pressure (PEEP) on inter-pleural pressure variation in horse anesthesia. Braz J Vet Res Anim Sci 35, 260-265.
Marntell S, Nyman G, Hedenstierna G (2005) High inspired oxygen concentrations increase intrapulmonary shunt in anaesthetized horses. Veterinary Anaesth Analg 32, 338-347.
Mason DE, Muir WW, Wade A (1987) Arterial blood gas tensions in the horse during recovery from anesthesia. J Am Vet Med Assoc 190, 989-994.
McMurphy RM, Cribb PH (1989) Alleviation of postanesthetic hypoxemia in the horse. Can Vet J 30, 37-41.
Patroniti N, Cortinovis B, Pesenti A. (2004) Pressure support ventilation in patients with ALI/ARDS. In: Update in Intensive Care and Emergency Medicine - Mechanical Ventilation, Slutsky AS, Brochard L, Vicent JL (ed.). Springer, Berlin, Germany. pp. 367-379.
Robinson NE (2009) The respiratory system. In: Equine Anesthesia: Monitoring and Emergency Therapy, Muir WW, Hubbell JAE (eds.). WB Saunders, St. Louis, MO. pp. 11-36.
Santos M, Fuente M, Garcia-Iturralde R et al. (2003) Effects of alpha-2 adrenoreceptor agonists during recovery from isoflurane anaesthesia in horses. Equine Vet J 35, 170-176.
Taniguchi C, Eid RC, Saghabi C et al. (2009) Automatic versus manual pressure support reduction in the weaning of post-operative patients: a randomised controlled trial. Crit Care 13, R6.
Whitehair KJ, Steffey EP, Willits NH et al. (1993) Recovery of horses from inhalation anesthesia. Am J Vet Res 54, 1693-1702.
Wolff K, Moens Y (2010) Gas exchange during inhalation anaesthesia of horses: a comparison between immediate versus delayed start of intermittent positive pressure ventilation - A clinical study. Pferdeheilkunde 26, 706-711.
Wright BD, Hildebrand SV (2001) An evaluation of apnea or spontaneous ventilation in early recovery following mechanical ventilation in the anesthetized horse. Veterinary Anaesth Analg 28, 26-33.
Yang KL, Tobin MJ (1991) A prospective study of indexes predicting the outcome of trials of weaning from mechanical ventilation. New Engl J Med 324, 1445-1450.