[en] OBJECTIVE: To evaluate equine cardiopulmonary function and recovery quality after administration of 0.25 or 0.50 mg/kg xylazine intravenously (IV) during recovery. STUDY DESIGN: Randomized, blinded, prospective, clinical study. ANIMALS: Horses (n = 20). METHODS: During recovery after 3 hours of isoflurane anesthesia for arthroscopic surgery, horses were administered either 0.25 mg/kg (G25, n = 10) or 0.50 mg/kg (G50, n = 10) xylazine intravenously. Vital signs and arterial blood samples were obtained during recovery before sedation (baseline), 5, 10, 20, 30, and 45 minutes after xylazine and 30 minutes after standing. The quality of recovery scores ranged from 10 to 72 (10 = best, 72 = worst). RESULTS: G25 horses recovered faster (mean +/- SD, 33 +/- 5 min) than G50 horses (50 +/- 7 min, P < .0001). Mean maximal decrease in arterial oxygen tension was 55 +/- 11 mmHg in G25 (at 10 minutes; P < .05) and 54 +/- 7 mmHg in G50 (at 20 minutes; P < .01). G25 group had a total recovery score (23 [range 18-29]) and number of attempts to stand (4 +/- 2) greater than the G50 group (18 [10-23] and 1 +/- 1, respectively; P < .001). CONCLUSIONS: Both doses of xylazine promoted a moderate and transient hypoxemia during recovery; however, the 0.5 mg/kg dose produced a longer and improved quality of recovery from anesthesia.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Ida, Keila ; Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Anesthésiologie et réanimation vétérinaires
Fantoni, Denise T.
Ibiapina, Bruna T.
Souto, Maria-Teresa M. R.
Zoppa, Andre L. V.
Silva, Luis Claudio L. C.
Ambrosio, Aline M.
Language :
English
Title :
Effect of postoperative xylazine administration on cardiopulmonary function and recovery quality after isoflurane anesthesia in horses.
Publication date :
2013
Journal title :
Veterinary Surgery
ISSN :
0161-3499
eISSN :
1532-950X
Publisher :
Wiley-Blackwell, United States - Florida
Volume :
42
Issue :
7
Pages :
877-84
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
(c) Copyright 2013 by The American College of Veterinary Surgeons.
Whitehair KJ, Steffey EP, Willits NH, et al: Recovery of horses from inhalation anesthesia. Am J Vet Res 2000; 54:1693-1700
Matthews N, Miller S, Hartsfield S: Comparisons of recoveries from halothane vs isoflurane anesthesia in horses. J Am Vet Med Assoc 1992; 201:559-563
Donaldson LL, Dunlop GS, Holland MS, et al: The recovery of horses from inhalant anesthesia: a comparison of halothane and isoflurane. Vet Surg 2000; 29:92-101
Durongphongtorn S, McDonell WN, Kerr CL, et al: Comparison of hemodynamic, clinicopathologic, and gastrointestinal motility effects and recovery characteristics of anesthesia with isoflurane and halothane in horses undergoing arthroscopic surgery. Am J Vet Res 2006; 67:32-42
Santos M, Fuente M, Garcia-Iturralde P, et al: Effects of alpha-2 adrenoceptor agonists during recovery from isoflurane anaesthesia in horses. Equine Vet J 2003; 35:170-175
Matthews NS, Hartsfield SM, Mercer D, et al: Recovery from sevoflurane anesthesia in horses: comparison to isoflurane and effect of postmedication with xylazine. Vet Surg 1998; 27:480-485
Clark-Price SC, Posner LP, Gleed RD: Recovery of horses from general anesthesia in a darkened or illuminated recovery stall. Vet Anaesth Analg 2008; 35:473-479
Johnston GM, Eastment JK, Wood JLN, et al: The confidential enquiry in perioperative equine fatalities (CEPEF); mortality results of phases 1 and 2. Vet Anaesth Analg 2002; 29:159-170
Young SS, Taylor PM: Factor influencing the outcome of equine anaesthesia: a review of 1, 314 cases. Equine Vet J 1993; 25:147-151
Wilderjans H: The 1 man rope assisted recovery from anaesthesia in horses, in Proceedings of the 10th International Congress of the World Equine Veterinary Association. Moscow, Russia, 2008.
Dzikiti TB, Bester L, Cilliers I, et al: Limb fracture during recovery from general anesthesia: an often tragic complication of equine anesthesia. J S Afr Vet Assoc 2008; 79:145-148
England GC, Clarke KW, Goossens L: A comparison of the sedative effects of three alpha 2-adrenoceptor agonists (romifidine, detomidine and xylazine) in the horse. J Vet Pharmacol Ther 1992; 15:194-201
Taylor PM, Clarke KW: Anaesthetic problems, in Taylor PM, Clarke KW (eds): Handbook of equine anaesthesia (ed 2). London, UK, Saunders, 2007, pp 123-176
Hubbell JAE, Muir WW: Use of the alpha-2 agonists xylazine and detomidine in the perianaesthetic period in the horse. Equine Vet Educ 2004; 16:326-332
Muir WW, Hubbell JAE: Anesthetic-associated complications, in Muir WW, Hubbell JAE (eds): Equine anesthesia: monitoring and emergency therapy (ed 2). St. Louis, MI, Saunders, 2009, pp 397-417
Wagner AE, Muir WW, Hinchcliff KW: Cardiovascular effects of xylazine and detomidine in horses. Am J Vet Res 1991; 52:651-657
Yamashita K, Tsubakishita S, Futaok S, et al: Cardiovascular effects of medetomidine, detomidine and xylazine in horses. J Vet Med Sci 2000; 62:1025-1032
Mason DE, Muir WW: Arterial blood gas tensions in the horse during recovery from anesthesia. J Am Vet Med Assoc 1987; 190:989-994
McMurphy RM, Cribb PH: Alleviation of postanesthetic hypoxemia in the horse. Can Vet J 1998; 30:37-41
Nyman G, Hedenstierna G: Ventilation-perfusion relationships in the anaesthetized horse. Equine Vet J 1989; 21:274-281
Hopster K, Kästner SB, Rohn K, et al: Intermittent positive pressure ventilation with constant positive end-expiratory pressure and alveolar recruitment manoeuvre during inhalation anaesthesia in horses undergoing surgery for colic, and its influence on the early recovery period. Vet Anaesth Analg 2011; 38:169-177
Hubbell JA, Aarnes TK, Bednarski RM, et al: Effect of 50% and maximal inspired oxygen concentrations on respiratory variables in isoflurane-anesthetized horses. BMC Vet Res 2011; 7:23
Hall LW, Gillespie JR: Alveolar-arterial oxygen tension differences in anaesthetized horses. Br J Anaesth 1968; 40:560-568
Hall LW: Disturbances of cardiopulmonary function in anaesthetised horses. Equine Vet J 1971; 3:95-98
Hall LW, Trim CM: Positive end-expiratory pressure in anaesthetized spontaneously breathing horses. Br J Anaesth 1975; 47:819-824
Day TK, Gaynor JS, Muir WW, et al: Blood gas values during intermittent positive pressure ventilation and spontaneous ventilation in 160 anesthetized horses positioned in lateral or dorsal recumbency. Vet Surg 1995; 24:266-276
Hall LW, Clarke KW, Trim CM: Pulmonary gas exchange: artificial ventilations of the lungs, in Hall LW, Clark KW, Trim CM (eds): Veterinary anaesthesia (ed 10). London, UK, Saunders, 2001, pp 179-196
Staffieri F, Bauquier SH, Moate PJ, et al: Pulmonary gas exchange in anaesthetised horses mechanically ventilated with oxygen or a helium/oxygen mixture. Equine Vet J 2009; 41:747-752
Marntell S, Nyman G, Hedenstierna G: High inspired oxygen concentrations increase intrapulmonary shunt in anaethetized horses. Vet Anaesth Analg 2005; 32:338-347
Cuvelliez SG, Eicker SW, McLauchlan C, Brunson DB: Cardiovascular and respiratory effects of inspired oxygen fraction in halothane-anesthetized horses. Am J Vet Res 1990; 51:1226-1231
Tomasic M, Mann LS, Soma LR: Effects of sedation, anesthesia, and endotracheal intubation on respiratory mechanics in adult horses. Am J Vet Res 1997; 58:641-646
Hall LW: Cardiovascular and pulmonary effects of recumbency in two conscious ponies. Equine Vet J 1984; 16:89-92
Gleed RD, Dobson A: Improvement in arterial oxygen tension with change in posture in anaesthetized horses. Res Vet Sci 1988; 44:255-259
Wright BD, Hildebrand SV: An evaluation of apnea or spontaneous ventilation in early recovery following mechanical ventilation in the anesthetized horse. Vet Anaesth Analg 2001; 28:26-33
Thurmon JC, Neff-Davis C, Davis LE, et al: Xylazine hydrochloride induced hyperglycemia and hypo-insulinaemia in Thoroughbred horses. J Vet Pharmacol Ther 1982; 5:241-245
Skarda RT, Muir WW III: Analgesic, hemodynamic, and respiratory effects of caudal epidurally admnistered xylazine hydrochloride solution in mares. Am J Vet Res 1996; 57:193-199
Wood T, Stanley S, Woods WE, et al: Evaluation of threshold doses of drug action in the horse using hematocrit values as an indicator. Res Commun Chem Pathol Pharmacol 1992; 75:231-241
Singh S, Young SS, McDonell WN, et al: Modification of cardiopulmonary and intestinal motility effects of xylazine with glycopyrrolate in horses. Can J Vet Res 1997; 61:99-107
Robertson SAL, Carter SW, Donovan M, et al: Effects of intravenous xylazine hydrochloride on blood glucose, plasma insulin and rectal temperature in neonatal foals. Equine Vet J 1990; 22:43-47
Wagner AE, Wagner AE, Mama KR, et al: A comparison of equine recovery characteristics after isoflurane or isoflurane followed by a xylazine-ketamine infusion. Vet Anaesth Analg 2008; 35:154-160
