Reference : Scalable Photocatalytic Oxidation of Methionine under Continuous-Flow Conditions
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/212966
Scalable Photocatalytic Oxidation of Methionine under Continuous-Flow Conditions
English
Emmanuel, Noémie mailto [Université de Liège > Département de chimie (sciences) > Center for Integrated Technology and Organic Synthesis - CiTOS > >]
Mendoza Gallego, Carlos mailto [Université de Liège > Department of Chemical Engineering > Génie chimique - Nanomatériaux et interfaces >]
Winter, Marc [Corning Reactor Technologies, Corning SAS > > > >]
Horn R, Clemens [Corning SAS > > > >]
Vizza, Alessandra [Corning Reactor Technologies, Corning SAS > > > >]
Dreesen, Laurent mailto [Université de Liège > Département de physique > Biophotonique >]
Heinrichs, Benoît mailto [Université de Liège > Department of Chemical Engineering > Génie chimique - Nanomatériaux et interfaces >]
Monbaliu, Jean-Christophe mailto [Université de Liège > Département de chimie (sciences) > Center for Integrated Technology and Organic Synthesis - CiTOS > >]
2017
Organic Process Research and Development
21
1435-1438
Yes (verified by ORBi)
International
1083-6160
1520-586X
[en] Flow Chemistry ; Continuous-flow process ; Photocatalytic oxidation ; Singlet oxygen ; Sulfoxides ; Sustainable conditions
[en] Highly efficient and chemoselective singlet oxygen oxidation of unprotected methionine was performed in water using a continuous mesofluidic reactor. Sustainable process engineering and conditions were combined to maximize process efficiency and atom-economy, with virtually no waste generation and safe operating conditions. Three water soluble metal-free photosensitizers (Rose Bengal, Methylene Blue, and tetrakis(4-carboxyphenyl)porphyrin) were assessed. The best results were obtained with Rose Bengal (0.1 mol%) at room temperature under white light irradiation and a slight excess of oxygen. Process and reaction parameters were monitored in real-time with in-line NMR. Other classical organic substrates (alpha-terpinene and citronellol) were oxidized under similar conditions with excellent performances.
French Community of Belgium (ARC grant, iCFlow 15/19-05)
Researchers ; Professionals
http://hdl.handle.net/2268/212966
10.1021/acs.oprd.7b00212
http://pubs.acs.org/doi/abs/10.1021/acs.oprd.7b00212
The research was funded through the ARC grant (iCFlow 15/19-05) for Concerted Research Actions, financed by the JCMM gratefully acknowledges financial support from the University of Liège (WG-13/03).

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