Reference : International Osteoporosis Foundation and European Calcified Tissue Society working g...
Scientific journals : Article
Human health sciences : General & internal medicine
http://hdl.handle.net/2268/212766
International Osteoporosis Foundation and European Calcified Tissue Society working group. Recommendations for the screening of the adherence to oral bisphosphonates.
English
DIEZ-PEREZ, A []
NAYLOR, K.E. []
ABRAHAMSEN, B []
AGNUSDEI, D []
Brandi, M.L. []
COOPER, C. []
DENNISON, E. []
ERIKSEN, E.F. []
GOLD, D.T. []
GUANABENS, N. []
HADJI, P. []
HILIGSMANN, M. []
HORNE, R. []
JOSSE, R. []
KANIS, J.A. []
OBERMAYER-PIETSCH, B. []
PRIETO-ALHAMBRA, D. []
Reginster, Jean-Yves mailto [Université de Liège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé >]
Rizzoli, R. []
SILVERMAN, M.C. []
ZILLIKENS, M.C. []
EASTELL, R. []
Mar-2017
Osteoporosis International
Springer Science & Business Media B.V.
28
3
767-774
Yes (verified by ORBi)
International
0937-941X
1433-2965
Godalming
United Kingdom
[en] Adherence ; Bisphosphonates ; Osteoporosis treatment ; Position paper ; Screening
[en] Summary: Adherence to oral bisphosphonates is low. A screening strategy is proposed based on the response of biochemical markers of bone turnover after 3 months of therapy. If no change is observed, the clinician should reassess the adherence to the treatment and also other potential issues with the drug. Introduction: Low adherence to oral bisphosphonates is a common problem that jeopardizes the efficacy of treatment of osteoporosis. No clear screening strategy for the assessment
of compliance is widely accepted in these patients.
Methods: The International Osteoporosis Foundation and the European Calcified Tissue Society have convened a working group to propose a screening strategy to detect a lack of adherence
to these drugs. The question to answer was whether the bone turnover markers (BTMs) PINP and CTX can be used to identify low adherence in patients with postmenopausal
osteoporosis initiating oral bisphosphonates for osteoporosis. The findings of the TRIO study specifically address this question and were used as the basis for testing the hypothesis.
Results: Based on the findings of the TRIO study, specifically addressing this question, the working group recommends measuring PINP and CTX at baseline and 3 months after
starting therapy to check for a decrease above the least significant change (decrease of more than 38% for PINP and 56% for CTX). Detection rate for the measurement of PINP is 84%,
for CTX 87% and, if variation in at least one is considered when measuring both, the level of detection is 94.5%.
Conclusions: If a significant decrease is observed, the treatment can continue, but if no decrease occurs, the clinician should reassess to identify problems with the treatment, mainly
low adherence.
http://hdl.handle.net/2268/212766
10.1007/s00198-017-3906-6

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