Alpha-lipoic acid impairs body weight gain of young broiler chicks via modulating peripheral AMPK.

[en] In mammals, the AMP-activated protein kinase (AMPK) pathways in the central and peripheral tissues coordinately integrate inputs from multiple sources to regulate energy balance. The present study was aimed to explore the potential role of hepatic AMPK in the energy homeostasis of broiler chickens. Diets with 0, 0.05% or 0.1% alpha-lipoic acid (alpha-LA), a known AMPK inhibitor were provided to broiler chicks for 7days. As a result, alpha-LA supplementation decreased the relative growth rate of broiler chicks. Hepatic AMPKalpha2 mRNA levels were significantly upregulated by dietary alpha-LA, in concert with the increased phosphorylated AMPKalpha protein levels. In addition, hepatic FAS mRNA levels together with the malonyl-CoA to total CoA ester ratio were reduced by alpha-LA supplementation. Moreover, the hepatic phosphorylated glycogen synthase levels were increased resulting in a markedly decreased hepatic glycogen content. In conclusion, dietary alpha-LA supplementation decreased the in vivo hepatic glycogenesis and lipogenesis via stimulating hepatic AMPKalpha mRNA levels and the phosphorylated gene product. The stimulatory effect of alpha-LA on hepatic AMPK mRNA and pAMPKalpha protein levels together with our previous observations regarding its inhibitory effect on hypothalamic AMPK may have altered the energy balance and hence impaired body weight gain of broiler chicks.

Disciplines :

Animal production & animal husbandry

Author, co-author :

Wang, Yufeng

Everaert, Nadia ; Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Ingénierie des productions animales et nutrition

Song, Zhigang

Decuypere, Eddy

Vermeulen, Daniel

Buyse, Johan

Language :

English

Title :

Alpha-lipoic acid impairs body weight gain of young broiler chicks via modulating peripheral AMPK.

Publication date :

2017

Journal title :

Comparative Biochemistry and Physiology. Part A, Molecular and Integrative Physiology

ISSN :

1095-6433

eISSN :

1531-4332

Publisher :

Elsevier, Netherlands

Volume :

211

Pages :

34-40

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 05 July 2017

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