Reference : The miR-183/ItgA3 axis is a key regulator of prosensory area during early inner ear d...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/212571
The miR-183/ItgA3 axis is a key regulator of prosensory area during early inner ear development
English
Van Den Ackerveken, Priscilla mailto [Université de Liège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
Mounier, Anaïs mailto [Université de Liège > > GIGA - Neurosciences >]
Huyghe, Aurélia [> >]
SACHELI, Rosalie mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service de microbiologie clinique >]
Van Lerberghe, Pierre-Bernard mailto [Université de Liège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
Volvert, marie-laure [> >]
Delacroix, Laurence mailto [Université de Liège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
Nguyen, Laurent mailto [Université de Liège > > GIGA - Neurosciences >]
Malgrange, Brigitte mailto [Université de Liège > > GIGA - Neurosciences >]
2017
Cell Death & Differentiation
Nature Publishing Group
Yes (verified by ORBi)
International
1350-9047
London
United Kingdom
[en] cochlea ; development ; miRNA
[en] MicroRNAs are important regulators of gene expression and are involved in cellular processes such as proliferation or differentiation, particularly during development of numerous organs including the inner ear. However, it remains unknown if miRNAs are required during the earliest stages of otocyst and cochlear duct development. Here, we report that a conditional loss of Dicer expression in the otocyst impairs the early development of the inner ear as a result of the accumulation of DNA damage that trigger p53-mediated apoptosis. Moreover, cochlear progenitors in the prosensory domain do not exit the cell cycle. Our unbiased approach identified ItgA3 as a target of miR-183, which are both enriched in the otic vesicle. We observed that the repression of integrin alpha 3 by miR-183 controls cell proliferation in the developing cochlea. Collectively, our results reveal that Dicer and miRNAs play essential roles in the regulation of early inner ear development.Cell Death and Differentiation advance online publication, 4 August 2017; doi:10.1038/cdd.2017.127.
Giga-Neurosciences
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; Fonds Léon Fredericq ; Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA
Researchers
http://hdl.handle.net/2268/212571
also: http://hdl.handle.net/2268/213676
10.1038/cdd.2017.127

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