Single- or double-unit UCBT following RIC in adults with AL: a report from Eurocord, the ALWP and the CTIWP of the EBMT.

Baron, Frédéric; Ruggeri, Annalisa; Beohou, Eric; Labopin, Myriam; Mohty, Mohamad; Blaise, Didier; Cornelissen, Jan J.; Chevallier, Patrice; Sanz, Guillermo; Petersen, Eefke; Savani, Bipin N.; Gluckman, Eliane; Nagler, Arnon

doi:10.1186/s13045-017-0497-9

Article (Scientific journals)

Single- or double-unit UCBT following RIC in adults with AL: a report from Eurocord, the ALWP and the CTIWP of the EBMT.

Baron, Frédéric; Ruggeri, Annalisa; Beohou, Eric et al.

2017 • In Journal of Hematology and Oncology, 10 (1), p. 128

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https://hdl.handle.net/2268/212263

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10.1186/s13045-017-0497-9

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28637512

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Keywords :

ALL; AML; Double; Reduced-intensity; Single; Transplantation; UCB; Unrelated cord blood

Abstract :

[en] BACKGROUND: The feasibility of cord blood transplantation (CBT) in adults is limited by the relatively low number of hematopoietic stem/progenitor cells contained in one single CB unit. The infusion of two CB units from different partially HLA-matched donors (double CBT) is frequently performed in patients who lack a sufficiently rich single CB unit. METHODS: We compared CBT outcomes in patients given single or double CBT following reduced-intensity conditioning (RIC) in a retrospective multicenter registry-based study. Inclusion criteria included adult (>/=18 years) patients, acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL), complete remission (CR) at the time of transplantation, first single (with a cryopreserved TNC >/= 2.5 x 107/kg) or double CBT between 2004 and 2014, and RIC conditioning. RESULTS: Data from 534 patients with AML (n = 408) or ALL (n = 126) receiving a first single (n = 172) or double (n = 362) CBT were included in the analyses. In univariate analysis, in comparison to patients transplanted with a single CB, double CB recipients had a similar incidence of neutrophil engraftment but a suggestion for a higher incidence of grade II-IV acute GVHD (36 versus 28%, P = 0.08). In multivariate analyses, in comparison to single CBT recipients, double CBT patients had a comparable incidence of relapse (HR = 0.9, P = 0.5) and of nonrelapse mortality (HR = 0.8, P = 0.3), as well as comparable overall (HR = 0.8, P = 0.17), leukemia-free (HR = 0.8, P = 0.2) and GVHD-free, relapse-free (HR = 1.0, P = 0.3) survival. CONCLUSIONS: These data failed to demonstrate better transplantation outcomes in adult patients receiving double CBT in comparison to those receiving single CBT with adequate TNC after RIC.

Disciplines :

Oncology

Author, co-author :

Baron, Frédéric ; Université de Liège > GIGA-R : Hématologie

Ruggeri, Annalisa

Beohou, Eric

Labopin, Myriam

Mohty, Mohamad

Blaise, Didier

Cornelissen, Jan J.

Chevallier, Patrice

Sanz, Guillermo

Petersen, Eefke

More authors (3 more)

Language :

English

Title :

Single- or double-unit UCBT following RIC in adults with AL: a report from Eurocord, the ALWP and the CTIWP of the EBMT.

Publication date :

2017

Journal title :

Journal of Hematology and Oncology

eISSN :

1756-8722

Publisher :

BioMed Central, London, United Kingdom

Volume :

Issue :

Pages :

128

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 27 June 2017

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