Article (Scientific journals)
Internal ribosome entry site-based vectors for combined gene therapy.
Renaud-Gabardos, Edith; Hantelys, Fransky; Morfoisse, Florent et al.
2015In World journal of experimental medicine, 5 (1), p. 11-20
Peer reviewed
 

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Keywords :
Gene therapy; Gene transfer; Internal ribosome entry site; Vector
Abstract :
[en] Gene therapy appears as a promising strategy to treat incurable diseases. In particular, combined gene therapy has shown improved therapeutic efficiency. Internal ribosome entry sites (IRESs), RNA elements naturally present in the 5' untranslated regions of a few mRNAs, constitute a powerful tool to co-express several genes of interest. IRESs are translational enhancers allowing the translational machinery to start protein synthesis by internal initiation. This feature allowed the design of multi-cistronic vectors expressing several genes from a single mRNA. IRESs exhibit tissue specificity, and drive translation in stress conditions when the global cell translation is blocked, which renders them useful for gene transfer in hypoxic conditions occurring in ischemic diseases and cancer. IRES-based viral and non viral vectors have been used successfully in preclinical and clinical assays of combined gene therapy and resulted in therapeutic benefits for various pathologies including cancers, cardiovascular diseases and degenerative diseases.
Disciplines :
Biotechnology
Author, co-author :
Renaud-Gabardos, Edith
Hantelys, Fransky
Morfoisse, Florent ;  Université de Liège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Chaufour, Xavier
Garmy-Susini, Barbara
Prats, Anne-Catherine
Language :
English
Title :
Internal ribosome entry site-based vectors for combined gene therapy.
Publication date :
2015
Journal title :
World journal of experimental medicine
ISSN :
2220-315X
Volume :
5
Issue :
1
Pages :
11-20
Peer reviewed :
Peer reviewed
Available on ORBi :
since 02 June 2017

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