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Lymphatic vasculature requires estrogen receptor alpha signaling to protect from lymphedema
Morfoisse, Florent
20177ème Congrès de la Société Française d'Angiogenèse
 

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Keywords :
lymphedema; estrogen; hormone therapy
Abstract :
[en] Rationale: Estrogen play a crucial role on the cardiovascular system and, particularly, on the vascular endothelium. However, the effect of estrogen on the lymphatic system has been poorly investigated. Objective: We aimed to demonstrate the protective effect of the 17 estradiol (E2), the most potent endogenous estrogen in lymphedema, a lymphatic dysfunction, which results in a massive fluid and fat accumulation. Methods and Results: Immunohistochemistry revealed that high doses of E2 modified skin microenvironment and stimulated lymphangiogenesis. E2 activates lymphatic endothelium through a transcriptional activation induced by its receptor ER. Using an original model of secondary lymphedema, we found a protective effect of E2 that prevents limb swelling. Loss of ER function using selective estrogen modulator (SERM) and in Tie2 Cre(+); ER-/- mice lead to a disruption of the lymphatic network promoting lymphedema. This effect was associated with a remodeling of LEC, an inhibition of gene expression, and ERK, but not AKT E2-induced phosphorylation. Conclusion: These findings reveal a new facet of the influence of estrogens in the management of the lymphatic system in pathological condition and provides more evidences that secondary lymphedema is not only a side effect of surgery, but is worsen by hormone therapy.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Morfoisse, Florent ;  Université de Liège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Language :
English
Title :
Lymphatic vasculature requires estrogen receptor alpha signaling to protect from lymphedema
Publication date :
24 April 2017
Event name :
7ème Congrès de la Société Française d'Angiogenèse
Event organizer :
Barbara Garmy-susini
Event place :
toulouse, France
Event date :
du 23 au 25 avril 2017
Audience :
International
Available on ORBi :
since 09 May 2017

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