[en] Abstract
Adipsic diabetes insipidus is a rare complication of intracranial tumors in which impaired antidiuretic hormone secretion is associated with the
loss of thirst sensation. Here, we present the case of a patient with bifocal intracranial germinoma, diagnosed due to symptoms mainly caused by
adipsic diabetes insipidus. This is, to our knowledge, the first case of adipsic diabetes insipidus revealing an intracranial germinoma reported in
the literature. We describe the diagnostic procedures and the three-year follow-up of this patient. Management of intracranial germ-cell tumors is
made complex by the wide range of histological features. Although germinomas have a generally better prognosis than most nongerminomatous
tumors, they can have severe or even life-threatening presentations. Adipsic diabetes insipidus is one such severe presentation and its rarity can
make it difficult to recognize and manage. Awareness of this potential entity is therefore important for clinical practice.
Le diabète insipide adipsique est une des rares complications des tumeurs intracrâniennes. Il associe une baisse de la sécrétion d’hormone
antidiurétique à une perte de la sensation de soif et ilsignale souvent la présence d’une lésion qui atteint ou envahit l’hypothalamus. Nous présentons
le cas d’une patiente avec un germinome intracrânien bifocal diagnostiqué devant un tableau de diabète insipide adipsique. À notre connaissance,
il s’agit du premier cas de la littérature d’un diabète insipide révélant un germinome intracrânien. La prise en charge des tumeurs germinales
intracrâniennes est complexe du fait des phénotypes histologiques divers. Bien que les germinomes ont généralement un meilleur pronostic que
les tumeurs non-germinomateuses, ils peuvent avoir des présentations sévères. Le diabète insipide adipsique est une de ces présentations sévères
et sa rareté peut rendre son diagnostic et sa prise en charge difficiles. La reconnaissance de cette entité potentielle est, dès lors, importante pour la
pratique clinique
Disciplines :
Endocrinologie, métabolisme & nutrition
Auteur, co-auteur :
KREUTZ, Julie ; Centre Hospitalier Universitaire de Liège - CHU > Service médical de radiodiagnostic
Potorac, Iulia ; Université de Liège - ULiège > Doct. sc. médicales (Bologne)
LUTTERI, Laurence ; Centre Hospitalier Universitaire de Liège - CHU > Service de chimie clinique
GENNIGENS, Christine ; Centre Hospitalier Universitaire de Liège - CHU > Service d'oncologie médicale
MARTIN, Didier ; Centre Hospitalier Universitaire de Liège - CHU > Service de neurochirurgie
Daly, Adrian ; Université de Liège > Département des sciences cliniques > Endocrinologie
BONNEVILLE, Jean-François ; Centre Hospitalier Universitaire de Liège - CHU > Service médical de radiodiagnostic
TSHIBANDA, Luaba ; Centre Hospitalier Universitaire de Liège - CHU > Service médical de radiodiagnostic
BECKERS, Albert ; Centre Hospitalier Universitaire de Liège - CHU > Service d'endocrinologie clinique
Langue du document :
Anglais
Titre :
Adipsic diabetes insipidus revealing a bifocal intracranial germinoma
Titre traduit :
[en] Un cas de diabète insipide adipsique révélant un germinome intracrânien bifocal
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