Acromegaly; MRI; Somatostatin receptor ligands; T2-weighted signal intensity
Abstract :
[en] T2-weighted MRI signal intensity of GH-secreting pituitary adenomas is gaining recognition as a marker of disease characteristics and may be a predictor of response to treatment of acromegaly. Adenomas that are T2-hypointense are more common, are smaller and are less likely to invade the cavernous sinus compared to the T2-iso and hyperintense tumors. T2-hypointense tumors are also accompanied by higher IGF1 values at baseline. When presurgical somatostatin receptor ligand (SRL) therapy is administered, T2-hypointense adenomas have better hormonal responses and have greater tumor shrinkage. Adjuvant SRL therapy of patients with T2-hypointense tumors that are uncured by surgery is also associated with a better hormonal response. We review the studies that have dealt with the T2-weighted signal intensity of GH-secreting pituitary tumors and elaborate on the details and nuances of this promising avenue of research.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Potorac, Iulia ; Université de Liège - ULiège > Doct. sc. médicales (Bologne)
Beckers, Albert ; Université de Liège > Département des sciences cliniques > Endocrinologie
BONNEVILLE, Jean-François ; Centre Hospitalier Universitaire de Liège - CHU > Service médical de radiodiagnostic
Language :
English
Title :
T2-weighted MRI signal intensity as a predictor of hormonal and tumoral responses to somatostatin receptor ligands in acromegaly: a perspective.
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