Adolescent; Adult; Brain/pathology; Child; Cohort Studies; Diffusion Magnetic Resonance Imaging; Family Health; Female; Humans; Image Processing, Computer-Assisted; Male; Substance-Related Disorders/pathology; White Matter/pathology; Young Adult; diffusion tensor imaging; family history; frontal white matter; risk; substance use
Abstract :
[en] Individuals with a family history of substance use disorders (FH+) are at a greater risk of developing substance use disorders than their peers with no such family histories (FH-) and this vulnerability is proportional to the number of affected relatives (FH density). The risk for developing substance use disorders peaks during adolescence to early adulthood in the general population, and that is thought to be related to delayed maturation of frontocortical and frontostriatal functional circuits. We hypothesized that FH+ youth and young adults have impaired myelination of frontocortical and frontostriatal white matter tracts. We examined fractional anisotropy (FA) data in 80 FH+ and 34 FH- youths (12.9 +/- 1.0 years) and in 25 FH+ and 30 FH- young adults (24.3 +/- 3.4 years). FH+ youths had lower FA values in both frontocortical and frontostriatal tracts as well as parietocortical tracts including the anterior, superior and posterior corona radiata and the superior frontal-occipital fasciculus. Moreover, FA values in these tracts were negatively correlated with FH density. FH+ adults had lower FA values in two frontocortical tracts: the genu of the corpus callosum and anterior corona radiata and also significant negative correlations between FA and FH density in these same tracts. In both groups, lower FA values corresponded to higher radial diffusivity suggesting reduced axonal myelination. We interpreted our findings as evidence for impaired myelination of frontal white matter that was proportional to FH density. Our data suggest that deficits may partially resolve with age, paralleling an age-related decline in risk for developing substance use disorders.
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Bibliography
Achenbach TM (2001): Child behavior checklist for ages 6 to 18. Burlington, VT: University of Vermont, Research Center for Children, Youth, and Families.
Acheson A, Robinson JL, Glahn DC, Lovallo WR, Fox PT (2009): Differential activation of the anterior cingulate cortex and caudate nucleus during a gambling simulation in persons with a family history of alcoholism: Studies from the Oklahoma Family Health Patterns Project. Drug Alcohol Depend 100:17-23.
Acheson A, Richard DM, Mathias CW, Dougherty DM (2011a): Adults with a family history of alcohol related problems are more impulsive on measures of response initiation and response inhibition. Drug Alcohol Depend 117:198-203.
Acheson A, Vincent AS, Sorocco KH, Lovallo WR (2011b): Greater discounting of delayed rewards in young adults with family histories of alcohol and drug use disorders: Studies from the Oklahoma family health patterns project. Alcohol Clin Exp Res 35:1607-1613.
Andreasen NC, Endicott J, Stitzer RL, Winokur G (1977): The family history method using diagnostic criteria. Arch Gen Psychiatry 34:1229-1235.
APA (2000): Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR. Washington, DC: American Psychiatric Association.
Barbor TFde las Fuentes JR, Saunders JB, Grant M (1992): AUDIT: The Alcohol Use Disorders Identification Test: Guidelines for use in Primary Health Care. Geneva, Switzerlan: World Health Organization.
Basser PJ (1994): Focal magnetic stimulation of an axon. IEEE Trans Biomed Eng 41:601-606.
Beaulieu C (2002): The basis of anisotropic water diffusion in the nervous system-A technical review. NMR Biomed 15:435-455.
Beck AT, Steer RA, Ball R, Ranieri W (1996): Comparison of beck depression inventories -IA and -II in psychiatric outpatiens. J Pers Assess 67:588-597.
Blakemore SJ, Robbins TW (2012): Decision-making in the adolescent brain. Nat Neurosci 15:1184-1191.
Bucholz KK, Cadoret R, Cloninger CR, Dinwiddie SH, Hesselbrock VM, Nurnberger JI Jr, Reich T, Schmidt I, Schuckit MA (1994): A new, semi-structured psychiatric interview for use in genetic linkage studies: A report on the reliability of the SSAGA. J Stud Alcohol 55:149-158.
Budde MD, Kim JH, Liang HF, Schmidt RE, Russell JH, Cross AH, Song SK (2007): Toward accurate diagnosis of white matter pathology using diffusion tensor imaging. Magn Reson Med 57:688-695.
Cahalan D, Cisin IH (1968): American drinking practices: Summary of findings from a national probability sample: II. Measurement of massed versus spaced drinking. Quart J Stud Alcohol 29:642-656.
Chung A, Lyoo IK, Kim SJ, Hwang J, Bae SC, Sung YH, Sim ME, Song IC, Kim J, Chang KH, Renshaw PF (2007): Decreased frontal white-matter integrity in abstinent methamphetamine abusers. Int J Neuropsychopharmacol 10:765-775.
Clark DB, Cornelius JR, Kirisci L, Tarter RE (2005): Childhood risk categories for adolescent substance involvement: A general liability typology. Drug Alcohol Depend 77:13-21.
Cloninger CR, Bohman M, Sigvardsson S (1981): Inheritance of alcohol abuse: Cross fostering analysis of adopted men. Arch Gen Psychiatry 38:861-868.
Conturo TE, McKinstry RC, Akbudak E, Robinson BH (1996): Encoding of anisotropic diffusion with tetrahedral gradients: A general mathematical diffusion formalism and experimental results. Magn Reson Med 35:399-412.
Corporation P (1999): Psychological Coorporation, Wechsler Abbreviated Scale of Intelligence (WASI) Manual. San Antonio, TX: Harcourt Brace and Company.
Corral M, Holguin SR, Cadaveira F (2003): Neuropsychological characteristics of young children from high-density alcoholism families: A three-year follow-up. J Stud Alcohol 64:195-199.
Cservenka A, Herting MM, Nagel BJ (2012): Atypical frontal lobe activity during verbal working memory in youth with a family history of alcoholism. Drug Alcohol Depend 123:98-104.
Dawson DA, Harford TC, Grant BF (1992): Family history as a predictor of alcohol dependence. Alcohol Clin Exp Res 16:572-575.
Deckel AW (1999): Tests of executive functioning predict scores on the MacAndrew Alcoholism Scale. Prog Neuropsychopharmacol Biol Psychiatry 23:209-223.
Ernst M, Fudge JL (2009): A developmental neurobiological model of motivated behavior: Anatomy, connectivity and ontogeny of the triadic nodes. Neurosci Biobehav Rev 33:367-382.
Falconer DS (1965): The inheritance of liability to certain diseases, estimated from the incidence among relatives. Ann Hum Genet Lond 29:51-76.
Falconer DS (1967): The inheritance of liability to diseases with variable age of onset, with particular reference to diabetes mellitus. Ann Hum Genet 31:1-20.
Finn PR, Kleinman I, Pihl RO (1990): The lifetime prevalence of psychopathology in men with multigenerational family histories of alcoholism. J Nervous Mental Dis 178:500-504.
Flechsig P (1901): Developmental (myelogenetic) localisation of the cerebral cortex in the human. Lancet 158:1027-1030.
Gao W, Lin W, Chen Y, Gerig G, Smith JK, Jewells V, Gilmore JH (2009): Temporal and spatial development of axonal maturation and myelination of white matter in the developing brain. AJNR Am J Neuroradiol 30:290-296.
Glahn DC, Lovallo WR, Fox PT (2007): Reduced amygdala activation in young adults at high risk of alcoholism: Studies from the Oklahoma family health patterns project. Biol Psychiatry 61:1306-1309.
Glahn DC, Kent JW Jr, Sprooten E, Diego VP, Winkler AM, Curran JE, McKay DR, Knowles EE, Carless MA, Goring HH, Dyer TD, Olvera RL, Fox PT, Almasy L, Charlesworth J, Kochunov P, Duggirala R, Blangero J (2013): Genetic basis of neurocognitive decline and reduced white-matter integrity in normal human brain aging. Proc Natl Acad Sci USA 110:19006-19011.
Gough HG (1994): Theory, development, and interpretation of the CPI socialization scale. Psychol Rep 75:651-700.
Hasan KM, Iftikhar A, Kamali A, Kramer LA, Ashtari M, Cirino PT, Papanicolaou AC, Fletcher JM, Ewing-Cobbs L (2009a): Development and aging of the healthy human brain uncinate fasciculus across the lifespan using diffusion tensor tractography. Brain Res 1276:67-76.
Hasan KM, Kamali A, Iftikhar A, Kramer LA, Papanicolaou AC, Fletcher JM, Ewing-Cobbs L (2009b): Diffusion tensor tractography quantification of the human corpus callosum fiber pathways across the lifespan. Brain Res 1249:91-100.
Heitzeg MM, Nigg JT, Yau WY, Zucker RA, Zubieta JK (2010): Striatal dysfunction marks preexisting risk and medial prefrontal dysfunction is related to problem drinking in children of alcoholics. Biol Psychiatry 68:287-295.
Herting MM, Schwartz D, Mitchell SH, Nagel BJ (2010): Delay discounting behavior and white matter microstructure abnormalities in youth with a family history of alcoholism. Alcohol Clin Exp Res 34:1590-1602.
Hof PR, Cox K, Morrison JH (1990): Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: I. Superior frontal and inferior temporal cortex. J Comp Neurol 301:44-54.
Hollingshead AB (1975): Four Factor Index of Social Status. New Haven, CT: Yale University. p 22.
Iacono WG, Malone SM, McGue M (2008): Behavioral disinhibition and the development of early-onset addiction: Common and specific influences. Annu Rev Clin Psychol 4:325-348.
Jones DK, Horsfield MA, Simmons A (1999): Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging. Magn Reson Med 42:515-525.
Kanchibhotla SC, Mather KA, Wen W, Schofield PR, Kwok JB, Sachdev PS (2013): Genetics of ageing-related changes in brain white matter integrity-A review. Ageing Res Rev 12:391-401.
Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, Williamson D, Ryan N (1997): Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): Initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36:980-988.
Kochunov P, Lancaster JL, Glahn DC, Purdy D, Laird AR, Gao F, Fox P (2006): Retrospective motion correction protocol for high-resolution anatomical MRI. Hum Brain Mapp 27:957-962.
Kochunov P, Glahn D, Nichols T, Winkler A, Hong E, Holcomb H, Stein J, Thompson P, Curran J, Carless M, Olvera R, Johnson M, Cole S, Kochunov V, Kent J, Blangero J (2011a): Genetic analysis of cortical thickness and fractional anisotropy of water diffusion in the brain. Front Neurosci 5:1-15.
Kochunov P, Glahn DC, Lancaster J, Thompson PM, Kochunov V, Rogers B, Fox P, Blangero J, Williamson DE (2011b): Fractional anisotropy of cerebral white matter and thickness of cortical gray matter across the lifespan. Neuroimage 58:41-49.
Kochunov P, Williamson DE, Lancaster J, Fox P, Cornell J, Blangero J, Glahn DC (2012): Fractional anisotropy of water diffusion in cerebral white matter across the lifespan. Neurobiol Aging 33:9-20.
Lamantia AS, Rakic P (1990): Cytological and quantitative characteristics of four cerebral commissures in the rhesus monkey. J Comp Neurol 291:520-537.
Lieb R, Merikangas KR, Hofler M, Pfister H, Isensee B, Wittchen HU (2002): Parental alcohol use disorders and alcohol use and disorders in offspring: A community study. Psychol Med 32:63-78.
Lim KO, Wozniak JR, Mueller BA, Franc DT, Specker SM, Rodriguez CP, Silverman AB, Rotrosen JP (2008): Brain macrostructural and microstructural abnormalities in cocaine dependence. Drug Alcohol Depend 92:164-172.
Lin WC, Chou KH, Chen CC, Huang CC, Chen HL, Lu CH, Li SH, Wang YL, Cheng YF, Lin CP (2012): White matter abnormalities correlating with memory and depression in heroin users under methadone maintenance treatment. PloS One 7:e33809.
Liu IC, Chiu CH, Chen CJ, Kuo LW, Lo YC, Tseng WY (2010): The microstructural integrity of the corpus callosum and associated impulsivity in alcohol dependence: A tractography-based segmentation study using diffusion spectrum imaging. Psychiatry Res 184:128-134.
Lovallo WR, Yechiam E, Sorocco KH, Vincent AS, Collins FL (2006): Working memory and decision-making biases in young adults with a family history of alcoholism: Studies from the Oklahoma family health patterns project. Alcoholism Clin Exp Res 30:763-773.
Lovallo WR, Farag NH, Sorocco KH, Acheson A, Cohoon AJ, Vincent AS (2013): Early life adversity contributes to impaired cognition and impulsive behavior: Studies from the oklahoma family health patterns project. Alcohol Clin Exp Res 37:616-623.
Ma L, Hasan KM, Steinberg JL, Narayana PA, Lane SD, Zuniga EA, Kramer LA, Moeller FG (2009): Diffusion tensor imaging in cocaine dependence: Regional effects of cocaine on corpus callosum and effect of cocaine administration route. Drug Alcohol Depend 104:262-267.
Madler B, Drabycz SA, Kolind SH, Whittall KP, MacKay AL (2008): Is diffusion anisotropy an accurate monitor of myelination? Correlation of multicomponent T2 relaxation and diffusion tensor anisotropy in human brain. Magn Reson Imaging 26:874-888.
McCaul ME, Turkkan JS, Svikis DS, Bigelow GE, Cromwell CC (1990): Alcohol and drug use by college males as a function of family alcoholism history. Alcohol Clin Exp Res 14:467-471.
McGorry PD, Purcell R, Goldstone S, Amminger GP (2011): Age of onset and timing of treatment for mental and substance use disorders: Implications for preventive intervention strategies and models of care. Curr Opin Psychiatry 24:301-306.
McLaughlin NC, Paul RH, Grieve SM, Williams LM, Laidlaw D, DiCarlo M, Clark CR, Whelihan W, Cohen RA, Whitford TJ, Gordon E (2007): Diffusion tensor imaging of the corpus callosum: A cross-sectional study across the lifespan. Int J Dev Neurosci 25:215-221.
McQueeny T, Schweinsburg BC, Schweinsburg AD, Jacobus J, Bava S, Frank LR, Tapert SF (2009): Altered white matter integrity in adolescent binge drinkers. Alcohol Clin Exp Res 33:1278-1285.
Merikangas KR (1990): The genetic epidemiology of alcoholism. Psychol Med 20:11-22.
Merikangas KR, Stolar M, Stevens DE, Goulet J, Preisig MA, Fenton B, Zhang H, O'Malley SS, Rounsaville BJ (1998): Familial transmission of substance use disorders. Arch Gen Psychiatry 55:973-979.
Molina V, Papiol S, Sanz J, Rosa A, Arias B, Fatjo-Vilas M, Calama J, Hernandez AI, Becker J, Fananas L (2011): Convergent evidence of the contribution of TP53 genetic variation (Pro72Arg) to metabolic activity and white matter volume in the frontal lobe in schizophrenia patients. Neuroimage 56:45-51.
Pfefferbaum A, Sullivan EV, Hedehus M, Lim KO, Adalsteinsson E, Moseley M (2000): Age-related decline in brain white matter anisotropy measured with spatially corrected echo-planar diffusion tensor imaging. Magn Reson Med 44:259-268.
Pierpaoli C, Basser PJ (1996): Toward a quantitative assessment of diffusion anisotropy. Magn Reson Med 36:893-906.
Reich T, Edenberg HJ, Goate A, Williams JT, Rice JP, Van Eerdewegh P, Foroud T, Hesselbrock V, Schuckit MA, Bucholz K, Porjesz B, Li TK, Conneally PM, Nurnberger JI Jr, Tischfield JA, Crowe RR, Cloninger CR, Wu W, Shears S, Carr K, Crose C, Willig C, Begleiter H (1998): Genome-wide search for genes affecting the risk for alcohol dependence. Am J Med Genet 81:207-215.
Rice JP, Reich T, Bucholz KK, Neuman RJ, Fishman R, Rochberg N, Hesselbrock VM, Nurnberger JI Jr, Schuckit MA, Begleiter H (1995): Comparison of direct interview and family history diagnoses of alcohol dependence. Alcohol Clin Exp Res 19:1018-1023.
Romero MJ, Asensio S, Palau C, Sanchez A, Romero FJ (2010): Cocaine addiction: Diffusion tensor imaging study of the inferior frontal and anterior cingulate white matter. Psychiatry Res 181:57-63.
Ryan SR, Acheson A, Charles NE, Lake SL, Hernandez DL, Mathias CW, Dougherty DM (Under Review): Clinical and social/environmental characteristics in a community sample of children with and without family histories of substance use disorder in the San Antonio area: A descriptive study.
Saunders B, Farag N, Vincent AS, Collins FL Jr, Sorocco KH, Lovallo WR (2008): Impulsive errors on a Go-NoGo reaction time task: Disinhibitory traits in relation to a family history of alcoholism. Alcohol Clin Exp Res 32:888-894.
Schweinsburg AD, Paulus MP, Barlett VC, Killeen LA, Caldwell LC, Pulido C, Brown SA, Tapert SF (2004): An FMRI study of response inhibition in youths with a family history of alcoholism. Ann N Y Acad Sci 1021:391-394.
Sher KJ, Trull TJ (1994): Personality and disinhibitory psychopathology: Alcoholism and antisocial personality disorder. J Abnormal Psychol 103:92-102.
Sher KJ, Grekin ER, Williams NA (2004): The development of alcohol use disorders. Annu Rev Clin Psychol 22:1-22.
Silveri MM, Rogowska J, McCaffrey A, Yurgelun-Todd DA (2011): Adolescents at risk for alcohol abuse demonstrate altered frontal lobe activation during Stroop performance. Alcohol Clin Exp Res 35:218-228.
Slutske WS, Heath AC, Madden PA, Bucholz KK, Statham DJ, Martin NG (2002): Personality and the genetic risk for alcohol dependence. J Abnorm Psychol 111:124-133.
Smith SM, Jenkinson M, Johansen-Berg H, Rueckert D, Nichols TE, Mackay CE, Watkins KE, Ciccarelli O, Cader MZ, Matthews PM, Behrens TE (2006): Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data. Neuroimage 31:1487-1505.
Somerville LH, Casey BJ (2010): Developmental neurobiology of cognitive control and motivational systems. Curr Opin Neurobiol 20:236-241.
Song SK, Sun SW, Ju WK, Lin SJ, Cross AH, Neufeld AH (2003): Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia. Neuroimage 20:1714-1722.
Song SK, Yoshino J, Le TQ, Lin SJ, Sun SW, Cross AH, Armstrong RC (2005): Demyelination increases radial diffusivity in corpus callosum of mouse brain. Neuroimage 26:132-140.
Sowell ER, Peterson BS, Thompson PM, Welcome SE, Henkenius AL, Toga AW (2003): Mapping cortical change across the human life span. Nat Neurosci 6:309-315.
Stevens MC, Kaplan RF, Hesselbrock VM (2003): Executive-cognitive functioning in the development of antisocial personality disorder. Addict Behav 28:285-300.
Stoltenberg SF, Mudd SA, Blow FC, Hill EM (1998): Evaluating measures of family history of alcoholism: Density versus dichotomy. Addiction 93:1511-1520.
Sullivan EV, Adalsteinsson E, Hedehus M, Ju C, Moseley M, Lim KO, Pfefferbaum A (2001): Equivalent disruption of regional white matter microstructure in ageing healthy men and women. Neuroreport 12:99-104.
Tarter RE, Kirisci L, Mezzich A, Cornelius JR, Pajer K, Vanyukov M, Gardner W, Blackson T, Clark D (2003): Neurobehavioral disinhibition in childhood predicts early age at onset of substance use disorder. Am J Psychiatry 160:1078-1085.
Ulug AM, Barker PB, van Zijl PC (1995): Correction of motional artifacts in diffusion-weighted images using a reference phase map. Magn Reson Med 34:476-480.
Upadhyay J, Maleki N, Potter J, Elman I, Rudrauf D, Knudsen J, Wallin D, Pendse G, McDonald L, Griffin M, Anderson J, Nutile L, Renshaw P, Weiss R, Becerra L, Borsook D (2010): Alterations in brain structure and functional connectivity in prescription opioid-dependent patients. Brain 133:2098-2114.
Wakana S, Jiang H, Nagae-Poetscher LM, van Zijl PC, Mori S (2004): Fiber tract-based atlas of human white matter anatomy. Radiology 230:77-87.
Westlye LT, Walhovd KB, Dale AM, Bjornerud A, Due-Tonnessen P, Engvig A, Grydeland H, Tamnes CK, Ostby Y, Fjell AM (2010): Differentiating maturational and aging-related changes of the cerebral cortex by use of thickness and signal intensity. Neuroimage 52:172-185.
Wijtenburg SA, McGuire SA, Rowland LM, Sherman PM, Lancaster JL, Tate DF, Hardies LJ, Patel B, Glahn DC, Hong LE, Fox PT, Kochunov P (2012): Relationship between fractional anisotropy of cerebral white matter and metabolite concentrations measured using (1)H magnetic resonance spectroscopy in healthy adults. Neuroimage 66C:161-168.
Wood P, Bunger RP (1984): The biology of the oligodendrocyte. In: Norton WT, editor. Oligodendroglia. New York: Plenum Press. pp 1-46.
Zachary WT (1986): Shipley Institute of Living Scale Revised manual. Los Angeles: Western Psychological Services.
Zimmerman M, Coryell W, Pfohl B, Stangl D (1988): The reliability of the family history method for psychiatric diagnoses. Arch Gen Psychiatry 45:320-322.
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.