Article (Scientific journals)
Assessment of whole brain white matter integrity in youths and young adults with a family history of substance-use disorders.
Acheson, Ashley; Wijtenburg, S. Andrea; Rowland, Laura M. et al.
2014In Human Brain Mapping, 35 (11), p. 5401-13
Peer Reviewed verified by ORBi
 

Files


Full Text
nihms628371.pdf
Author preprint (633.11 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Adolescent; Adult; Brain/pathology; Child; Cohort Studies; Diffusion Magnetic Resonance Imaging; Family Health; Female; Humans; Image Processing, Computer-Assisted; Male; Substance-Related Disorders/pathology; White Matter/pathology; Young Adult; diffusion tensor imaging; family history; frontal white matter; risk; substance use
Abstract :
[en] Individuals with a family history of substance use disorders (FH+) are at a greater risk of developing substance use disorders than their peers with no such family histories (FH-) and this vulnerability is proportional to the number of affected relatives (FH density). The risk for developing substance use disorders peaks during adolescence to early adulthood in the general population, and that is thought to be related to delayed maturation of frontocortical and frontostriatal functional circuits. We hypothesized that FH+ youth and young adults have impaired myelination of frontocortical and frontostriatal white matter tracts. We examined fractional anisotropy (FA) data in 80 FH+ and 34 FH- youths (12.9 +/- 1.0 years) and in 25 FH+ and 30 FH- young adults (24.3 +/- 3.4 years). FH+ youths had lower FA values in both frontocortical and frontostriatal tracts as well as parietocortical tracts including the anterior, superior and posterior corona radiata and the superior frontal-occipital fasciculus. Moreover, FA values in these tracts were negatively correlated with FH density. FH+ adults had lower FA values in two frontocortical tracts: the genu of the corpus callosum and anterior corona radiata and also significant negative correlations between FA and FH density in these same tracts. In both groups, lower FA values corresponded to higher radial diffusivity suggesting reduced axonal myelination. We interpreted our findings as evidence for impaired myelination of frontal white matter that was proportional to FH density. Our data suggest that deficits may partially resolve with age, paralleling an age-related decline in risk for developing substance use disorders.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Psychiatry
Author, co-author :
Acheson, Ashley
Wijtenburg, S. Andrea
Rowland, Laura M.
Winkler, Anderson ;  Université de Liège - ULiège > Form. doc. sc. bioméd. & pharma.
Gaston, Frank
Mathias, Charles W.
Fox, Peter T.
Lovallo, William R.
Wright, Susan N.
Hong, L. Elliot
Dougherty, Donald M.
Kochunov, Peter
Language :
English
Title :
Assessment of whole brain white matter integrity in youths and young adults with a family history of substance-use disorders.
Publication date :
2014
Journal title :
Human Brain Mapping
ISSN :
1065-9471
eISSN :
1097-0193
Publisher :
John Wiley & Sons, Hoboken, United States - New York
Volume :
35
Issue :
11
Pages :
5401-13
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2014 Wiley Periodicals, Inc.
Available on ORBi :
since 04 May 2017

Statistics


Number of views
56 (1 by ULiège)
Number of downloads
129 (1 by ULiège)

Scopus citations®
 
34
Scopus citations®
without self-citations
22
OpenCitations
 
32

Bibliography


Similar publications



Contact ORBi