[en] BACKGROUND: Pathophysiological models of bipolar disorder postulate that mood dysregulation arises from fronto-limbic dysfunction, marked by reduced prefrontal cortex (PFC) inhibitory control. This might occur due to both disruptions within PFC networks and abnormal inhibition over subcortical structures involved in emotional processing. However, no study has examined global PFC dysconnectivity in bipolar disorder and tested whether regions with within-PFC dysconnectivity also exhibit fronto-limbic connectivity deficits. Furthermore, no study has investigated whether such connectivity disruptions differ for bipolar patients with psychosis history, who might exhibit a more severe clinical course. METHODS: We collected resting-state functional magnetic resonance imaging at 3T in 68 remitted bipolar I patients (34 with psychosis history) and 51 demographically matched healthy participants. We employed a recently developed global brain connectivity method, restricted to PFC (rGBC). We also independently tested connectivity between anatomically defined amygdala and PFC. RESULTS: Bipolar patients exhibited reduced medial prefrontal cortex (mPFC) rGBC, increased amygdala-mPFC connectivity, and reduced connectivity between amygdala and dorsolateral PFC. All effects were driven by psychosis history. Moreover, the magnitude of observed effects was significantly associated with lifetime psychotic symptom severity. CONCLUSIONS: This convergence between rGBC, seed-based amygdala findings, and symptom severity analyses highlights that mPFC, a core emotion regulation region, exhibits both within-PFC dysconnectivity and connectivity abnormalities with limbic structures in bipolar illness. Furthermore, lateral PFC dysconnectivity in patients with psychosis history converges with published work in schizophrenia, indicating possible shared risk factors. Observed dysconnectivity in remitted patients suggests a bipolar trait characteristic and might constitute a risk factor for phasic features of the disorder.
Disciplines :
Pediatrics Neurosciences & behavior
Author, co-author :
Anticevic, Alan
Brumbaugh, Margaret S.
Winkler, Anderson ; Université de Liège - ULiège > Form. doc. sc. bioméd. & pharma.
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Bibliography
E. Vieta, and M.L. Phillips Deconstructing bipolar disorder: A critical review of its diagnostic validity and a proposal for DSM-V and ICD-11 Schizophr Bull 33 2007 886 892
M.L. Phillips, C.D. Ladouceur, and W.C. Drevets A neural model of voluntary and automatic emotion regulation: Implications for understanding the pathophysiology and neurodevelopment of bipolar disorder Mol Psychiatry 13 829 2008 833 857
C.-H. Chen, J. Suckling, B.R. Lennox, C. Ooi, and E.T. Bullmore A quantitative meta-analysis of fMRI studies in bipolar disorder Bipolar Disord 13 2011 1 15
L. Altshuler, S. Bookheimer, M.A. Proenza, J. Townsend, F. Sabb, and A. Firestine Increased amygdala activation during mania: A functional magnetic resonance imaging study Am J Psychiatry 162 2005 1211 1213
H.P. Blumberg, J. Kaufman, A. Martin, R. Whiteman, J.H. Zhang, and J.C. Gore Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder Arch Gen Psychiatry 60 2003 1201 1208
C.H. Chen, J. Suckling, B.R. Lennox, C. Ooi, and E.T. Bullmore A quantitative meta-analysis of fMRI studies in bipolar disorder Bipolar Disord 13 2011 1 15
S.M. Strakowski, M.P. Delbello, and C.M. Adler The functional neuroanatomy of bipolar disorder: A review of neuroimaging findings Mol Psychiatry 10 2005 105 116
M.T. Keener, and M.L. Phillips Neuroimaging in bipolar disorder: A critical review of current findings Curr Psychiatry Rep 9 2007 512 520
L. Palaniyappan, and D.A. Cousins Brain networks: Foundations and futures in bipolar disorder J Ment Health 19 2010 157 167
N.A. Gray, R. Zhou, J. Du, G.J. Moore, and H.K. Manji The use of mood stabilizers as plasticity enhancers in the treatment of neuropsychiatric disorders J Clin Psychiatry 64 2003 3 17
R.J. Schloesser, J. Huang, P.S. Klein, and H.K. Manji Cellular plasticity cascades in the pathophysiology and treatment of bipolar disorder Neuropsychopharmacology 33 2008 110 133
C.A. Zarate, J. Singh, and H.K. Manji Cellular plasticity cascades: Targets for the development of novel therapeutics for bipolar disorder Biol Psychiatry 59 2006 1006 1020
Raichle ME, Snyder AZ (2007): A default mode of brain function: A brief history of an evolving idea. Neuroimage 37:1083-1090; discussion 1097-1089.
M.D. Fox, A.Z. Snyder, J.L. Vincent, M. Corbetta, D.C. Van Essen, and M.E. Raichle The human brain is intrinsically organized into dynamic, anticorrelated functional networks Proc Natl Acad Sci U S A 102 2005 9673 9678
S.M. Smith, P.T. Fox, K.L. Miller, D.C. Glahn, P.M. Fox, and C.E. Mackay Correspondence of the brain's functional architecture during activation and rest Proc Natl Acad Sci U S A 106 2009 13040 13045
J.L. Vincent, G.H. Patel, M.D. Fox, A.Z. Snyder, J.T. Baker, and D.C. Van Essen Intrinsic functional architecture in the anaesthetized monkey brain Nature 447 2007 83 U84
M.D. Greicius, K. Supekar, V. Menon, and R.F. Dougherty Resting-state functional connectivity reflects structural connectivity in the default mode network Cereb Cortex 19 2009 72 78
M.D. Fox, and M. Greicius Clinical applications of resting state functional connectivity Front Syst Neurosci 4 2010 19
V.D. Calhoun, P.K. Maciejewski, G.D. Pearlson, and K.A. Kiehl Temporal lobe and default hemodynamic brain modes discriminate between schizophrenia and bipolar disorder Hum Brain Mapp 29 2008 1265 1275
A. Anand, Y. Li, Y. Wang, M.J. Lowe, and M. Dzemidzic Resting state corticolimbic connectivity abnormalities in unmedicated bipolar disorder and unipolar depression Psychiatry Res 171 2009 189 198
L.G. Chepenik, M. Raffo, M. Hampson, C. Lacadie, F. Wang, and M.M. Jones Functional connectivity between ventral prefrontal cortex and amygdala at low frequency in the resting state in bipolar disorder Psychiatry Res 182 2010 207 210
J.L. Price, S.T. Carmichael, and W.C. Drevets Networks related to the orbital and medial prefrontal cortex: A substrate for emotional behavior? Prog Brain Res 107 1996 523 536
H. Barbas Anatomic basis of cognitive-emotional interactions in the primate prefrontal cortex Neurosci Biobehav Rev 19 1995 499 510
H. Barbas Flow of information for emotions through temporal and orbitofrontal pathways J Anat 211 2007 237 249
H.T. Ghashghaei, C.C. Hilgetag, and H. Barbas Sequence of information processing for emotions based on the anatomic dialogue between prefrontal cortex and amygdala Neuroimage 34 2007 905 923
T.R. Insel, and B.N. Cuthbert Endophenotypes: Bridging genomic complexity and disorder heterogeneity Biol Psychiatry 66 2009 988 989
F.K. Goodwin, and K.R. Jamison Manic Depressive Illness 1990 Oxford University Press New York
E. Dunayevich, and P.E. Keck Jr Prevalence and description of psychotic features in bipolar mania Curr Psychiatry Rep 2 2000 286 290
J.B. Potash, V.L. Willour, Y.P.D. Chiu, S.G. Simpson, D.F. MacKinnon, and G.D. Pearlson The familial aggregation of psychotic symptoms in bipolar disorder pedigrees Am J Psychiatry 158 2001 1258 1264
F. Bellivier, J.L. Golmard, C. Henry, M. Leboyer, and F. Schurhoff Admixture analysis of age at onset in bipolar I affective disorder Arch Gen Psychiatry 58 2001 510 512
W. Coryell, A.C. Leon, C. Turvey, H.S. Akiskal, T. Mueller, and J. Endicott The significance of psychotic features in manic episodes: A report from the NIMH collaborative study J Affect Disord 67 2001 79 88
P.E. Keck Jr, S.L. McElroy, J.R. Havens, L.L. Altshuler, W.A. Nolen, and M.A. Frye Psychosis in bipolar disorder: Phenomenology and impact on morbidity and course of illness Compr Psychiatry 44 2003 263 269
D.C. Glahn, C.E. Bearden, M. Barguil, J. Barrett, A. Reichenberg, and C.L. Bowden The neurocognitive signature of psychotic bipolar disorder Biol Psychiatry 62 2007 910 916
H.C. Strasser, J. Lilyestrom, E.R. Ashby, N.A. Honeycutt, D.J. Schretlen, and A.E. Pulver Hippocampal and ventricular volumes in psychotic and nonpsychotic bipolar patients compared with schizophrenia patients and community control subjects: A pilot study Biol Psychiatry 57 2005 633 639
G.D. Pearlson, D.F. Wong, L.E. Tune, C.A. Ross, G. Chase, and J.M. Links In vivo D2 dopamine receptor density in psychotic and nonpsychotic patients with bipolar disorder Arch Gen Psychiatry 52 1995 471 477
M.W. Cole, A. Anticevic, G. Repovs, and D.M. Barch Variable global dysconnectivity and individual differences in schizophrenia Biol Psychiatry 70 2011 43 50
R.L. Buckner, J. Sepulcre, T. Talukdar, F.M. Krienen, H. Liu, and T. Hedden Cortical hubs revealed by intrinsic functional connectivity: Mapping, assessment of stability, and relation to Alzheimer's disease J Neurosci 29 2009 1860 1873
M.W. Cole, S. Pathak, and W. Schneider Identifying the brain's most globally connected regions Neuroimage 49 2010 3132 3148
R. Martuzzi, R. Ramani, M. Qiu, X. Shen, X. Papademetris, and R.T. Constable A whole-brain voxel based measure of intrinsic connectivity contrast reveals local changes in tissue connectivity with anesthetic without a priori assumptions on thresholds or regions of interest Neuroimage 58 2011 1044 1050
M.B. First, R.L. Spitzer, M. Gibbon, and J.B.W. Williams Structured Clinical Interview for the DSM-IV-TR Axis I Disorders 2001 American Psychiatric Press Washington, DC
D. Wechsler Wechsler Abbreviated Scale of Intelligence 1999 The Psychological Corporation San Antonio
D.C. Glahn, C.E. Bearden, S. Cakir, J.A. Barrett, P. Najt, and E. Serap Monkul Differential working memory impairment in bipolar disorder and schizophrenia: Effects of lifetime history of psychosis Bipolar Disord 8 2006 117 123
M. Hamilton Development of a rating scale for primary depressive illness Br J Soc Clin Psychol 6 1967 278 296
R. Young, J. Biggs, V. Ziegler, and D. Meyer A rating scale for mania: Reliability, validity and sensitivity Br J Psychiatry 133 1978 429 435
J. Ventura, M.F. Green, A. Shaner, and R.P. Liberman Training and quality assurance with the Brief Psychiatric Rating Scale: The drift busters Int J Method Psych 3 1993 221 244
B. Fischl, D.H. Salat, E. Busa, M. Albert, and M. Dieterich Whole brain segmentation automated labeling of neuroanatomical structures in the human brain Neuron 33 2002 341 355
A. Anticevic, G. Repovs, and D.M. Barch Resisting emotional interference: Brain regions facilitating working memory performance during negative distraction Cogn Affect Behav Neurosci 10 2010 159 173
A. Anticevic, G. Repovs, and D.M. Barch Emotion effects on attention, amygdala activation, and functional connectivity in schizophrenia [published online ahead of print Mar 17] Schizophr Bull 2011
A. Anticevic, G. Repovs, G.L. Shulman, and D.M. Barch When less is more: TPJ and default network deactivation during encoding predicts working memory performance Neuroimage 49 2010 2638 2648
B. Fischl, D.H. Salat, A.J. van der Kouwe, N. Makris, F. Ségonne, and B.T. Quinn Sequence-independent segmentation of magnetic resonance images Neuroimage 23 suppl 1 2004 S69 S84
S.D. Forman, J.D. Cohen, M. Fitzgerald, W.F. Eddy, M.A. Mintun, and D.C. Noll Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): Use of a cluster-size threshold Magn Reson Med 33 1995 636 647
N. Kriegeskorte, W.K. Simmons, P.S. Bellgowan, and C.I. Baker Circular analysis in systems neuroscience: The dangers of double dipping Nat Neurosci 12 2009 535 540
X.J. Chai, S. Whitfield-Gabrieli, A.K. Shinn, J.D. Gabrieli, A. Nieto Castanon, and J.M. McCarthy Abnormal medial prefrontal cortex resting-state connectivity in bipolar disorder and schizophrenia Neuropsychopharmacology 36 2011 2009 2017
M. Beckmann, H. Johansen-Berg, and M.F. Rushworth Connectivity-based parcellation of human cingulate cortex and its relation to functional specialization J Neurosci 29 2009 1175 1190
R.M. Hutchison, T. Womelsdorf, J.S. Gati, L.S. Leung, R.S. Menon, and S. Everling Resting-state connectivity identifies distinct functional networks in macaque cingulate cortex Cereb Cortex 22 2011 1294 1308
H. Johansen-Berg, D.A. Gutman, T.E. Behrens, P.M. Matthews, M.F. Rushworth, and E. Katz Anatomical connectivity of the subgenual cingulate region targeted with deep brain stimulation for treatment-resistant depression Cereb Cortex 18 2007 1374 1383
J.L. Price, and W.C. Drevets Neural circuits underlying the pathophysiology of mood disorders Trends Cogn Sci 16 2011 61 71
C.M. Lewis, A. Baldassarre, G. Committeri, G.L. Romani, and M. Corbetta Learning sculpts the spontaneous activity of the resting human brain Proc Natl Acad Sci U S A 106 2009 17558 17563
G.J. Quirk, R. Garcia, and F. González-Lima Prefrontal mechanisms in extinction of conditioned fear Biol Psychiatry 60 2006 337 343
H.J. Kang, Y.I. Kawasawa, F. Cheng, Y. Zhu, X. Xu, and M. Li Spatio-temporal transcriptome of the human brain Nature 478 2011 483 489
M.S. Keshavan, D.W. Morris, J.A. Sweeney, G.D. Pearlson, G.K. Thaker, and L.J. Seidman A dimensional approach to the psychosis spectrum between bipolar disorder and schizophrenia: The Schizo-Bipolar Scale Schizophr Res 133 2011 250 254
S.A. Meda, A. Gill, M.C. Stevens, R.P. Lorenzoni, D.C. Glahn, and V.D. Calhoun Differences in resting-state functional magnetic resonance imaging functional network connectivity between schizophrenia and psychotic bipolar probands and their unaffected first-degree relatives Biol Psychiatry 71 2012 881 889
M. Soyka, W. Koch, H.J. Möller, T. Rüther, and K. Tatsch Hypermetabolic pattern in frontal cortex and other brain regions in unmedicated schizophrenia patients. Results from a FDG-PET study Eur Arch Psychiatry Clin Neurosci 255 2005 308 312
S.R. Laviolette, W.J. Lipski, and A.A. Grace A subpopulation of neurons in the medial prefrontal cortex encodes emotional learning with burst and frequency codes through a dopamine D4 receptor-dependent basolateral amygdala input J Neurosci 25 2005 6066 6075
M.L. Phillips, M.J. Travis, A. Fagiolini, and D.J. Kupfer Medication effects in neuroimaging studies of bipolar disorder Am J Psychiatry 165 2008 313 320
D.F. Levinson, B.J. Mowry, M.A. Escamilla, and S.V. Faraone The Lifetime Dimensions of Psychosis Scale (LDPS): Description and interrater reliability Schizophr Bull 28 2002 683 695
Similar publications
Sorry the service is unavailable at the moment. Please try again later.
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.