[en] In presence of β-lactam antibiotic in its environment, B. licheniformis produces the β-lactamase BlaP, an enzyme hydrolyzing β-lactam antibiotic, conferring on the bacteria phenotypic resistance. To induce BlaP, two conditions must be fulfilled. The first one is the acylation of the membrane receptor BlaR1 by the antibiotic. The second one is a cellular stress due to the presence of the antibiotic which acylate PBP1. The nature of this signal remains unknown.
In this study we postulate that the extracytoplasmic function sigma factors (ECFs) σM and σX act together with the stringent response as a secondary and redundant layer of stress upon which the BlaP induction pathway relies.
Research Center/Unit :
CIP - Centre d'Ingénierie des Protéines - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Dauvin, Marjorie ; Université de Liège > Département des sciences de la vie > Physiologie et génétique bactériennes
Joris, Bernard ; Université de Liège > Département des sciences de la vie > Physiologie et génétique bactériennes
Language :
English
Title :
Cellular stress and β-lactamase BlaP induction in Bacillus licheniformis
Alternative titles :
[fr] Stress cellulaire et induction de la β-lactamase BlaP chez Bacillus licheniformis
Publication date :
01 February 2017
Number of pages :
A0
Event name :
1st InBioSDay
Event organizer :
Paulette Charlier
Event place :
Liège, Belgium
Event date :
1er février 2017
Name of the research project :
Etude de l'induction de la β-lactamase BlaP chez Bacillus licheniformis
