The effects of plant polyphenols on enterotoxigenic Escherichia coli adhesion and toxin binding

[en] Pigs frequently encounter bacterial infections like enterotoxigenic Escherichia coli (ETEC). Due to rising concerns about antibiotic resistance of bacteria, there is a large demand for natural alternatives to combat these ETEC infections. Plant polyphenols have been suggested to reduce both the binding of cholera toxin to the GM1 ganglioside and the adhesion of uropathogenic E. coli to F1 fimbriae. In this study different commercial natural polyphenol extracts were evaluated for their possible effect on ETEC. Out of the three polyphenol extracts tested two exert inhibitory effects on the heat-labile toxin binding and all three extracts reduced the binding of ETEC to brush borders. The presence of protein abolished labile toxin binding properties of polyphenols. This makes it unlikely that these polyphenols could be used as an actual feed additive to combat ETEC caused diarrhea. © 2010 Elsevier B.V.

Disciplines :

Animal production & animal husbandry

Author, co-author :

Verhelst, R.; Livestock-Nutrition-Quality Division, Leuven Food Science and Nutrition Research Centre (LFoRCe), Katholieke Universiteit Leuven, Kasteelpark Arenberg 30, Box 2456, 3001 Heverlee, Belgium, Department of Biosystems, Katholieke Universiteit Leuven, Kasteelpark Arenberg 30, box 2456, 3001 Heverlee, Belgium

Schroyen, Martine ; Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Zootechnie

Buys, N.; Livestock Genetics, Katholieke Universiteit Leuven, Kasteelpark Arenberg 30, Box 2456, 3001 Heverlee, Belgium, Department of Biosystems, Katholieke Universiteit Leuven, Kasteelpark Arenberg 30, box 2456, 3001 Heverlee, Belgium

Niewold, T.; Livestock-Nutrition-Quality Division, Leuven Food Science and Nutrition Research Centre (LFoRCe), Katholieke Universiteit Leuven, Kasteelpark Arenberg 30, Box 2456, 3001 Heverlee, Belgium, Department of Biosystems, Katholieke Universiteit Leuven, Kasteelpark Arenberg 30, box 2456, 3001 Heverlee, Belgium

Title :

The effects of plant polyphenols on enterotoxigenic Escherichia coli adhesion and toxin binding

Publication date :

2010

Journal title :

Livestock Science

ISSN :

1871-1413

eISSN :

1878-0490

Publisher :

Elsevier Science, Amsterdam, Netherlands

Volume :

133

Issue :

1-3

Pages :

101-103

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 24 April 2017

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Bibliography

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