Article (Scientific journals)
Multipotent mesenchymal stromal cell therapy for steroid-refractory acute graft-versus-host disease after allogeneic stem cell transplantation
SERVAIS, Sophie; GREGOIRE, Céline; BARON, Frédéric et al.
2016In Belgian Journal of Hematology, 7, p. 229-235
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Keywords :
acute graft-versus-host disease; allogeneic stem cell transplantation; multipotent mesenchymal stromal cells
Abstract :
[en] Steroid-refractory acute graft-versus-host disease is a severe complication after allogeneic stem cell transplantation. So far, its treatment remains very challenging since the current therapies do not offer significant benefits. Among the most recent approaches, multipotent mesenchymal stromal cell-based therapy has attracted great interest over the past decade. Here, we briefly reviewed the current knowledges about the immunomodulatory properties of multipotent mesenchymal stromal cells as well as results of preclinical and clinical studies having assessed their efficacy to modulate steroid-refractory acute graft-versus-host disease.
Disciplines :
Hematology
Author, co-author :
SERVAIS, Sophie ;  Centre Hospitalier Universitaire de Liège - CHU > Service d'hématologie clinique
GREGOIRE, Céline  ;  Centre Hospitalier Universitaire de Liège - CHU > Frais communs médecine - Pool assistants
BARON, Frédéric  ;  Centre Hospitalier Universitaire de Liège - CHU > Service d'hématologie clinique
WILLEMS, Evelyne ;  Centre Hospitalier Universitaire de Liège - CHU > Service d'hématologie clinique
BRIQUET, Alexandra ;  Centre Hospitalier Universitaire de Liège - CHU > Service d'hématologie clinique
BAUDOUX, Etienne  ;  Centre Hospitalier Universitaire de Liège - CHU > Thérapie cellulaire
DELLOYE, Olivier ;  Centre Hospitalier Universitaire de Liège - CHU > Service d'hématologie clinique
GIET, Olivier ;  Centre Hospitalier Universitaire de Liège - CHU > Thérapie cellulaire
LECHANTEUR, Chantal ;  Centre Hospitalier Universitaire de Liège - CHU > Thérapie cellulaire
BEGUIN, Yves  ;  Centre Hospitalier Universitaire de Liège - CHU > Service d'hématologie clinique
Language :
English
Title :
Multipotent mesenchymal stromal cell therapy for steroid-refractory acute graft-versus-host disease after allogeneic stem cell transplantation
Publication date :
2016
Journal title :
Belgian Journal of Hematology
ISSN :
2033-3749
Publisher :
Ariez Medical Publishing, Amsterdam, Netherlands
Volume :
7
Pages :
229-235
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 March 2017

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