In vitro biphasic dissolution tests and their suitability for establishing in vitro-in vivo correlations: A historical review

Pestieau, Aude; Evrard, Brigitte

doi:10.1016/j.ejps.2017.03.019

Article (Scientific journals)

In vitro biphasic dissolution tests and their suitability for establishing in vitro-in vivo correlations: A historical review

Pestieau, Aude; Evrard, Brigitte

2017 • In European Journal of Pharmaceutical Sciences, 102, p. 203-219

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/208448

DOI
10.1016/j.ejps.2017.03.019

PubMed
28315463

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Abstract :

[en] For many decades, one of the most critical issues in the pharmaceutical industry has been the poor solubility of some drugs. Indeed, a prerequisite for drug absorption is the presence of dissolved drug at the absorption site and this can be challenging for compounds with low aqueous solubility such as BCS class II (low solubility, high permeability) and IV (low solubility, low permeability) compounds. If the development of oral delivery formulations of these compounds is frequently challenging to formulation scientists in the pharmaceutical industry, the in vitro evaluation of these new formulations is also a great challenge. One alternative approach to overcome the problems encountered with conventional dissolution methods is the use of biphasic dissolution systems. This review provides an overview of the origin and the evolution over time of the biphasic systems and the growing interest among scientists regarding their suitability for establishing in vitro-in vivo correlations. The evolution of these systems and their applications from the 1960s to the present day, such as in system variants and improvements, analysis of complex formulations, discriminatory power, bio-relevance, precipitation and supersaturation visualization, etc. will be discussed.

Research Center/Unit :

CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Pestieau, Aude ; Université de Liège > Département de pharmacie > Pharmacie galénique

Evrard, Brigitte ; Université de Liège > Département de pharmacie > Pharmacie galénique

Language :

English

Title :

In vitro biphasic dissolution tests and their suitability for establishing in vitro-in vivo correlations: A historical review

Publication date :

01 May 2017

Journal title :

European Journal of Pharmaceutical Sciences

ISSN :

0928-0987

eISSN :

1879-0720

Publisher :

Elsevier Science, Amsterdam, Netherlands

Volume :

102

Pages :

203-219

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 21 March 2017

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