Reference : Photoreversibility and biocompatibility of polydimethylsiloxane-coumarin as adjustabl...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/208269
Photoreversibility and biocompatibility of polydimethylsiloxane-coumarin as adjustable intraocular lens material
English
Jellali, Rachid [University of Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM)]
Bertrand, Virginie [University of Liège (ULg), GIGA-R, Laboratory of Mammalian Cell Culture > > > >]
Alexandre, Michaël [University of Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM)]
Rosière, Nancy [University of Liège (ULg), GIGA-R, Laboratory of Mammalian Cell Culture > > > >]
Grauwels, Magda [University of Liège (ULg), Département Clinique des Animaux de Compagnie et des Équidés > > > >]
De Pauw-Gillet, Marie-Claire mailto [University of Liège (ULg), GIGA-R, Laboratory of Mammalian Cell Culture > > > >]
Jérôme, Christine mailto [University of Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM)]
2017
Macromolecular Bioscience
1600495
Yes (verified by ORBi)
International
1616-5187
1616-5195
[en] biomaterial ; implant ; intraocular lens
[en] Polydimethylsiloxane (PDMS) constitutes an interesting material for a variety of biomed- ical applications, especially as intraocular lenses (IOLs), for its excellent transparency. In this work, a photoreversible PDMS-coumarin network, whose shape and properties can be adjusted postoperatively in a noninvasive manner, is developed. The synthesis of PDMS-cou- marin is achieved by amidation of a coumarin acid chloride derivative with amine-function- alized PDMSs. Under exposure of λ > 300 nm, these polymers can be cured by dimerization of coumarin. The cured polymers can be uncrosslinked via photocleavage of cyclobutane dimers upon illumination at
λ < 290 nm. The diffusion of linear PDMSs in a crosslinked network and the controlled shape modification are studied, which demonstrate that these polymers are good candidates for adjustable IOL application. IOL disks prepared from these materials show high hydrophobicity and good transparency. In vitro cytotoxicity, lens epithelial cell adhesion assays, and rabbit host reaction against implanted disks demonstrate the biocompatibility of the polymer.
Center for Education and Research on Macromolecules (CERM) ; CESAM Complex and Entangled Systems from Atoms to Materials (CESAM)
Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; The Walloon Region in the frame of the SmartIOL and Lionel projects
Researchers
http://hdl.handle.net/2268/208269
10.1002/mabi.201600495

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