Weitzman I, Summerbell RC. The dermatophytes. Clin Microbiol Rev. 1995;8:240–59.
Chermette R, Ferreiro L, Guillot J. Dermatophytoses in animals. Mycopathologia. 2008;166:385–405.
Degreef H. Clinical forms of dermatophytosis (ringworm infection). Mycopathologia. 2008;166:257–65.
Seebacher C, Bouchara JP, Mignon B. Updates on the epidemiology of dermatophyte infections. Mycopathologia. 2008;166:335–52.
Ameen M. Epidemiology of superficial fungal infections. Clin Dermatol. 2010;28:197–201.
Gupta AK, Cooper EA. Update in antifungal therapy of dermatophytosis. Mycopathologia. 2008;166:353–67.
Lund A, Deboer DJ. Immunoprophylaxis of dermatophytosis in animals. Mycopathologia. 2008;166:407–24.
Brasch J. Current knowledge of host response in human tinea. Mycoses. 2009;52:304–12.
Mignon BR, Losson BJ. Prevalence and characterization of Microsporum canis carriage in cats. J Med Vet Mycol. 1997;35:249–56.
Saunte DM, Hasselby JP, Brillowska-Dabrowska A, et al. Experimental guinea pig model of dermatophytosis: a simple and useful tool for the evaluation of new diagnostics and antifungals. Med Mycol. 2008;46:303–13.
Staib P, Zaugg C, Mignon B, et al. Differential gene expression in the pathogenic dermatophyte Arthroderma benhamiae in vitro versus during infection. Microbiology. 2010;156:884–95.
Grumbt M, Defaweux V, Mignon B, et al. Targeted gene deletion and in vivo analysis of putative virulence gene function in the pathogenic dermatophyte Arthroderma benhamiae. Eukaryot Cell. 2011;10:842–53.
Knight AG. A review of experimental human fungus infections. J Invest Dermatol. 1972;59:354–8.
Reinhardt JH, Allen AM, Gunnison D, Akers WA. Experimental human Trichophyton mentagrophytes infections. J Invest Dermatol. 1974;63:419–22.
Kumar N, Goindi S. Statistically designed nonionic surfactant vesicles for dermal delivery of itraconazole: characterization and in vivo evaluation using a standardized Tinea pedis infection model. Int J Pharm. 2014;472:224–40.
Kumar N, Shishu. D-optimal experimental approach for designing topical microemulsion of itraconazole: characterization and evaluation of antifungal efficacy against a standardized Tinea pedis infection model in Wistar rats. Eur J Pharm Sci. 2015;67:97–112.
Green F, Weber JK, Balish E. The thymus dependency of acquired resistance to Trichophyton mentagrophytes dermatophytosis in rats. J Invest Dermatol. 1983;81:31–8.
Weber J, Balish E. Antifungal therapy of dermatophytosis in guinea pigs and congenitally athymic rats. Mycopathologia. 1985;90:47–54.
Faldyna M, Oborilova E, Krejci J, et al. A correlation of in vitro tests for the immune response detection: a bovine trichophytosis model. Vaccine. 2007;25:7948–54.
de Arruda MS, Gilioli S, Vilani-Moreno FR. Experimental dermatophytosis in hamsters inoculated with Trichophyton mentagrophytes in the cheek pouch. Rev Ins Med Trop São Paulo. 2001;43:29–32.
Shimamura T, Kubota N, Nagasaka S, et al. Establishment of a novel model of onychomycosis in rabbits for evaluation of antifungal agents. Antimicrob Agents Chemother. 2011;55:3150–5.
DeBoer DJ, Moriello KA. Development of an experimental model of Microsporum canis infection in cats. Vet Microbiol. 1994;42:289–95.
DeBoer DJ, Moriello KA. Inability of two topical treatments to influence the course of experimentally induced dermatophytosis in cats. J Am Vet Med Assoc. 1995;207:52–7.
Moriello KA, Deboer DJ, Schenker R, Blum JL, Volk LM. Efficacy of pre-treatment with lufenuron for the prevention of Microsporum canis infection in a feline direct topical challenge model. Vet Dermatol. 2004;15:357–62.
DeBoer DJ, Moriello KA. The immune response to Microporum canis induced by a fungal cell wall vaccine. Vet Dermatol. 1994;5:47–55.
DeBoer DJ, Moriello KA, Blum JL, Volk LM, Bredahl LK. Safety and immunologic effects after inoculation of inactivated and combined live-inactivated dermatophytosis vaccines in cats. Am J Vet Res. 2002;63:1532–7.
DeBoer DJ, Moriello KA. Investigations of a killed dermatophyte cell-wall vaccine against infection with Microsporum canis in cats. Res Vet Sci. 1995;59:110–3.
Achterman RR, Smith AR, Oliver BG, White TC. Sequenced dermatophyte strains: growth rate, conidiation, drug susceptibilities, and virulence in an invertebrate model. Fungal Genet Biol. 2011;48:335–41.
Cotter G, Doyle S, Kavanagh K. Development of an insect model for the in vivo pathogenicity testing of yeasts. FEMS Immunol Med Microbiol. 2000;27:163–9.
Cowen LE, Singh SD, Köhler JR, et al. Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease. Proc Natl Acad Sci USA. 2009;106:2818–23.
Jackson JC, Higgins LA, Lin X. Conidiation color mutants of Aspergillus fumigatus are highly pathogenic to the heterologous insect host Galleria mellonella. PLoS ONE. 2009;4:e4224.
Mowlds P, Kavanagh K. Effect of pre-incubation temperature on susceptibility of Galleria mellonella larvae to infection by Candida albicans. Mycopathologia. 2008;165:5–12.
Mylonakis E. Galleria mellonella and the study of fungal pathogenesis: making the case for another genetically tractable model host. Mycopathologia. 2008;165:1–3.
Reeves EP, Messina CGM, Doyle S, Kavanagh K. Correlation between gliotoxin production and virulence of Aspergillus fumigatus in Galleria mellonella. Mycopathologia. 2004;158:73–9.
St Leger RJ, Screen SE, Shams-Pirzadeh B. Lack of host specialization in Aspergillus flavus. Appl Environ Microbiol. 2000;66:320–4.
Jahn B, Koch A, Schmidt A, et al. Isolation and characterization of a pigmentless-conidium mutant of Aspergillus fumigatus with altered conidial surface and reduced virulence. Infect Immun. 1997;65:5110–7.
Tsai HF, Chang YC, Washburn RG, Wheeler MH, Kwon-Chung KJ. The developmentally regulated alb1 gene of Aspergillus fumigatus: its role in modulation of conidial morphology and virulence. J bacteriol. 1998;180:3031–8.
Aggarwal N, Goindi S. Preparation and evaluation of antifungal efficacy of griseofulvin loaded deformable membrane vesicles in optimized guinea pig model of Microsporum canis—dermatophytosis. Int J Pharm. 2012;437:277–87.
De Baltazar LM, Santos PC, de Paula TP, et al. IFN-γ impairs Trichophyton rubrum proliferation in a murine model of dermatophytosis through the production of IL-1β and reactive oxygen species. Med Mycol. 2014;52:293–302.
Calderon RA, Hay RJ. Cell-mediated immunity in experimental murine dermatophytosis. I. Temporal aspects of T-suppressor activity caused by Trichophyton quinckeanum. Immunology. 1984;53:457–64.
Garvey EP, Hoekstra WJ, Moore WR, et al. VT-1161 dosed once daily or once weekly exhibits potent efficacy in treatment of dermatophytosis in a guinea pig model. Antimicrob Agents Chemother. 2015;59:1992–7.
Ghannoum MA, Hossain MA, Long L, et al. Evaluation of antifungal efficacy in an optimized animal model of Trichophyton mentagrophytes—dermatophytosis. J Chemother. 2004;16:139–44.
Itoyama T, Uchida K, Yamaguchi H, Fujita S. Therapeutic effects of omoconazole nitrate on experimental tinea pedis, an intractable dermatophytosis, in guinea-pigs. J Antimicrob Chemother. 1997;40:441–4.
Koga H, Nanjoh Y, Kaneda H, Yamaguchi H, Tsuboi R. Short-term therapy with luliconazole, a novel topical antifungal imidazole, in guinea pig models of tinea corporis and tinea pedis. Antimicrob Agents Chemother. 2012;56:3138–43.
Majima T, Masui S, Uchida K, Yamaguchi H. A novel mycological analysis valuable for evaluating therapeutic efficacy of antimycotics against experimental dermatophytosis in guinea pigs. Mycoses. 2005;48:108–13.
Mikaeili A, Modaresi M, Karimi I, et al. Antifungal activities of Astragalus verus Olivier against Trichophyton verrucosum on in vitro and in vivo guinea pig model of dermatophytosis. Mycoses. 2012;55:318–25.
Nakashima T, Nozawa A, Ito T, Majima T, Yamaguchi H. Development of a new medium useful for the recovery of dermatophytes from clinical specimens by minimizing the carryover effect of antifungal agents. Microbiol Immunol. 2002;46:83–8.
Venturini J, Álvares AM, de Camargo MRD, et al. Dermatophyte-host relationship of a murine model of experimental invasive dermatophytosis. Microbes Infect. 2012;14:1144–51.
Cambier L, Weatherspoon A, Defaweux V, et al. Assessment of the cutaneous immune response during Arthroderma benhamiae and A. vanbreuseghemii infection using an experimental mouse model. Br J Dermatol. 2014;170:625–33.
Hunjan BS, Cronholm LS. An animal model for cell-mediated immune responses to dermatophytes. J Allergy Clin Immunol. 1979;63:361–9.
Odds F, Ausma J, Van Gerven F, et al. In vitro and in vivo activities of the novel azole antifungal agent r126638. Antimicrob Agents Chemother. 2004;48:388–91.
Singh G, Kumar P, Joshi SC. Treatment of dermatophytosis by a new antifungal agent “apigenin”. Mycoses. 2014;57:497–506.
Cambier L, Băguţ E-T, Heinen M-P, et al. Assessment of immunogenicity and protective efficacy of Microsporum canis secreted components coupled to monophosphoryl lipid-A adjuvant in a vaccine study using guinea pigs. Vet Microbiol. 2015;175:304–11.
Baldo A, Mathy A, Tabart J, et al. Secreted subtilisin Sub3 from Microsporum canis is required for adherence to but not for invasion of the epidermis. Br J Dermatol. 2010;162:990–7.
Fujita S, Matsuyama T. Experimental tinea pedis induced by non-abrasive inoculation of Trichophyton mentagrophytes arthrospores on the plantar part of a guinea pig foot. J Med Vet Mycol. 1987;25:203–13.
Greenberg JH, King RD, Krebs S, Field R. A quantitative dermatophyte infection model in the guinea pig—a parallel to the quantitated human infection model. J Invest Dermatol. 1976;67:704–8.
Prasad CS, Shukla R, Kumar A, Dubey NK. In vitro and in vivo antifungal activity of essential oils of Cymbopogon martini and Chenopodium ambrosioides and their synergism against dermatophytes. Mycoses. 2010;53:123–9.
Lau K-M, Wong JH, Wu Y-O, et al. Anti-dermatophytic activity of bakuchiol: in vitro mechanistic studies and in vivo tinea pedis-inhibiting activity in a guinea pig model. Phytomedicine. 2014;21:942–5.
Chittasobhon N, Smith JM. The production of experimental dermatophyte lesions in guinea pigs. J Invest Dermatol. 1979;73:198–201.
Nakamura T, Nishibu A, Yasoshima M, et al. Analysis of Trichophyton antigen-induced contact hypersensitivity in mouse. J Dermatol Sci. 2012;66:144–53.
Mei Y, Dai X, Yang W, Xu X, Liang Y. Antifungal activity of chitooligosaccharides against the dermatophyte Trichophyton rubrum. Int J Biol Macromol. 2015;77:330–5.
Calderon RA, Hay RJ. Cell-mediated immunity in experimental murine dermatophytosis. II. Adoptive transfer of immunity to dermatophyte infection by lymphoid cells from donors with acute or chronic infections. Immunology. 1984;53:465–72.
Hay RJ, Calderon RA, Collins MJ. Experimental dermatophytosis: the clinical and histopathologic features of a mouse model using Trichophyton quinckeanum (mouse favus). J Invest Dermatol. 1983;81:270–4.
Treiber A, Pittermann W, Schuppe HC. Efficacy testing of antimycotic prophylactics in an animal model. Int J Hyg Environ Health. 2001;204:239–43.
Chen X-J, Shen Y-N, Lü G-X, Liu W-D. Establishing an experimental guinea pig model of dermatophytosis using Trichophyton rubrum. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2008;30:599–602.
Mao L, Zhang L, Li H, Chen W, et al. Pathogenic fungus Microsporum canis activates the NLRP3 inflammasome. Infect Immun. 2014;82:882–92.
Pier AC, Hodges AB, Lauze JM, Raisbeck M. Experimental immunity to Microsporum canis and cross reactions with other dermatophytes of veterinary importance. J Med Vet Mycol. 1995;33:93–7.
Li Z-J, Guo X, Dawuti G, Aibai S. Antifungal activity of ellagic acid in vitro and in vivo. Phytother Res. 2015;29:1019–25.
Arika T, Yokoo M, Hase T, et al. Effects of butenafine hydrochloride, a new benzylamine derivative, on experimental dermatophytosis in guinea pigs. Antimicrob Agents Chemother. 1990;34:2250–3.
Arika T, Yokoo M, Maeda T, Amemiya K, Yamaguchi H. Effects of butenafine hydrochloride, a new benzylamine derivative, on experimental tinea pedis in guinea pigs. Antimicrob Agents Chemother. 1990;34:2254–5.
Meerpoel L, Backx LJJ, Van der Veken LJE, et al. Synthesis and in vitro and in vivo structure–activity relationships of novel antifungal triazoles for dermatology. J Med Chem. 2005;48:2184–93.
Paulussen C, de Wit K, Boulet G, et al. Pyrrolo[1,2-α][1,4]benzodiazepines show potent in vitro antifungal activity and significant in vivo efficacy in a Microsporum canis dermatitis model in guinea pigs. J Antimicrob Chemother. 2014;69:1608–10.
Saunte DM, Simmel F, Frimodt-Moller N, et al. In vivo efficacy and pharmacokinetics of voriconazole in an animal model of dermatophytosis. Antimicrob Agents Chemother. 2007;51:3317–21.
Arika T, Hase T, Yokoo M. Anti-Trichophyton mentagrophytes activity and percutaneous permeation of butenafine in guinea pigs. Antimicrob Agents Chemother. 1993;37:363–5.
Arika T, Yokoo M, Yamaguchi H. Topical treatment with butenafine significantly lowers relapse rate in an interdigital tinea pedis model in guinea pigs. Antimicrob Agents Chemother. 1992;36:2523–5.
Fu KP, Isaacson DM, Lococo J, Foleno B, Hilliard J. In vitro and in vivo antidermatophytic activity of saperconazole, a new fluorinated triazole. Drugs Exp Clin Res. 1992;18:443–6.
Ghannoum MA, Long L, Kim HG, et al. Efficacy of terbinafine compared to lanoconazole and luliconazole in the topical treatment of dermatophytosis in a guinea pig model. Med Mycol. 2010;48:491–7.
Ghannoum MA, Long L, Cirino AJ, et al. Efficacy of NVC-422 in the treatment of dermatophytosis caused by Trichophyton mentagrophytes using a guinea pig model. Int J Dermatol. 2013;52:567–71.
Ghannoum MA, Long L, Pfister WR. Determination of the efficacy of terbinafine hydrochloride nail solution in the topical treatment of dermatophytosis in a guinea pig model. Mycoses. 2009;52:35–43.
Iwata A, Watanabe Y, Kumagai N, et al. In vitro and in vivo assessment of dermatophyte acquired resistance to efinaconazole, a novel triazole antifungal. Antimicrob Agents Chemother. 2014;58:4920–2.
Knechtle P, Diefenbacher M, Greve KB, et al. The natural diyne–furan fatty acid EV-086 is an inhibitor of fungal delta-9 fatty acid desaturation with efficacy in a model of skin dermatophytosis. Antimicrob Agents Chemother. 2014;58:455–66.
Long L, Hager C, Ghannoum M. Evaluation of the efficacy of ME1111 in the topical treatment of dermatophytosis in a guinea pig model. Antimicrob Agents Chemother. 2016;60:2343–5.
Nicholas RO, Berry V, Hunter PA, Kelly JA. The antifungal activity of mupirocin. J Antimicrob Chemother. 1999;43:579–82.
Niwano Y, Kuzuhara N, Kodama H, et al. In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent. Antimicrob Agents Chemother. 1998;42:967–70.
Njateng GSS, Gatsing D, Mouokeu RS, Lunga PK, Kuiate J-R. In vitro and in vivo antidermatophytic activity of the dichloromethane-methanol (1:1 v/v) extract from the stem bark of Polyscias fulva Hiern (Araliaceae). BMC Complement Altern Med. 2013;13:95.
Hashiguchi T, Ryu A, Itoyama T, Uchida K, Yamaguchi H. Study of the effective dose of a topical antifungal agent, omoconazole nitrate, on the basis of percutaneous pharmacokinetics in guinea-pigs and mice. J Pharm Pharmacol. 1997;49:757–61.
Nagino K, Shimohira H, Ogawa M, Uchida K, Yamaguchi H. Comparison of the therapeutic efficacy of oral doses of fluconazole and itraconazole in a guinea pig model of dermatophytosis. J Infect Chemother. 2000;6:41–4.
Mieth H, Leitner I, Meingassner JG. The efficacy of orally applied terbinafine, itraconazole and fluconazole in models of experimental trichophytoses. J Med Vet Mycol. 1994;32:181–8.
Parmegiani RM, Loebenberg D, Cacciapuoti A, et al. Sch 39304, a new antifungal agent: oral and topical treatment of vaginal and superficial infections. J Med Vet Mycol. 1993;31:239–48.
Sugiura K, Sugimoto N, Hosaka S, et al. The low keratin affinity of efinaconazole contributes to its nail penetration and fungicidal activity in topical onychomycosis treatment. Antimicrob Agents Chemother. 2014;58:3837–42.
Tatsumi Y, Yokoo M, Arika T, Yamaguchi H. In vitro antifungal activity of KP-103, a novel triazole derivative, and its therapeutic efficacy against experimental plantar tinea pedis and cutaneous candidiasis in guinea pigs. Antimicrob Agents Chemother. 2001;45:1493–9.
Ghannoum MA, Long L, Kim HG, et al. Efficacy of terbinafine compared to lanoconazole and luliconazole in the topical treatment of dermatophytosis in a guinea pig model. Med Mycol. 2010;48:491–7.
Polak AM. Preclinical data and mode of action of amorolfine. Clin Exp Dermatol. 1992;17(Suppl 1):8–12.
Ohsumi K, Murai H, Nakamura I, Watanabe M, Fujie A. Therapeutic efficacy of AS2077715 against experimental tinea pedis in guinea pigs in comparison with terbinafine. J Antibiot. 2014;67:717–9.
Wakabayashi H, Uchida K, Yamauchi K, et al. Lactoferrin given in food facilitates dermatophytosis cure in guinea pig models. J Antimicrob Chemother. 2000;46:595–602.
Uchida K, Tanaka T, Yamaguchi H. Achievement of complete mycological cure by topical antifungal agent NND-502 in guinea pig model of tinea pedis. Microbiol Immunol. 2003;47:143–6.
Tatsumi Y, Yokoo M, Senda H, Kakehi K. Therapeutic efficacy of topically applied KP-103 against experimental tinea unguium in guinea pigs in comparison with amorolfine and terbinafine. Antimicrob Agents Chemother. 2002;46:3797–801.
Gasparto AK, Baltazar LM, Gouveia LF, et al. 2-(Benzylideneamino)phenol: a promising hydroxyaldimine with potent activity against dermatophytoses. Mycopathologia. 2015;179:243–51.
Thomson MP, Anticevic CS, Rodríguez BH, Silva VV. In vitro antifungal susceptibility, in vivo antifungal activity and security from a natural product obtained from sunrise oil (AMO3) against dermatophytes. Rev Chilena Infectol. 2011;28:512–9.
Baltazar LM, Werneck SMC, Carneiro HCS, et al. Photodynamic therapy efficiently controls dermatophytosis caused by Trichophyton rubrum in a murine model. Br J Dermatol. 2015;172:801–4.
Mignon BR, Leclipteux T, Focant C, et al. Humoral and cellular immune response to a crude exo-antigen and purified keratinase of Microsporum canis in experimentally infected guinea pigs. Med Mycol. 1999;37:123–9.
Vermout SM, Brouta FD, Descamps FF, Losson BJ, Mignon BR. Evaluation of immunogenicity and protective efficacy of a Microsporum canis metalloprotease subunit vaccine in guinea pigs. FEMS Immunol Med Microbiol. 2004;40:75–80.
Viani FC, Dos Santos JI, Paula CR, Larson CE, Gambale W. Production of extracellular enzymes by Microsporum canis and their role in its virulence. Med Mycol. 2001;39:463–8.
Baldo A, Tabart J, Vermout S, et al. Secreted subtilisins of Microsporum canis are involved in adherence of arthroconidia to feline corneocytes. J Med Microbiol. 2008;57:1152–6.
Bagut ET, Baldo A, Mathy A, et al. Subtilisin Sub3 is involved in adherence of Microsporum canis to human and animal epidermis. Vet Microbiol. 2012;160:413–9.
Hay RJ, Calderon RA, Mackenzie CD. Experimental dermatophytosis in mice: correlation between light and electron microscopic changes in primary, secondary and chronic infections. Br J Exp Pathol. 1988;69:703–16.
Tran VDT, De Coi N, Feuermann M, et al. RNA sequencing-based genome reannotation of the dermatophyte Arthroderma benhamiae and characterization of its secretome and whole gene expression profile during infection. mSystems. 2016. doi:10.1128/mSystems.00036-16.
Hunjan BS, Silverman IH, Curlovic KM, et al. A simplified in vitro assay of delayed hypersensitivity in diagnosis of dermatomycoses. J Allergy Clin Immunol. 1981;67:485–94.
Descamps FF, Brouta F, Vermout SM, et al. A recombinant 31.5 kDa keratinase and a crude exo-antigen from Microsporum canis fail to protect against a homologous experimental infection in guinea pigs. Vet Dermatol. 2003;14:305–12.
Wakabayashi H, Takakura N, Yamauchi K, et al. Effect of lactoferrin feeding on the host antifungal response in guinea-pigs infected or immunised with Trichophyton mentagrophytes. J Med Microbiol. 2002;51:844–50.
Yoshikawa FSY, Ferreira LG, de Almeida SR. IL-1 signaling inhibits Trichophyton rubrum conidia development and modulates the IL-17 response in vivo. Virulence. 2015;6:449–57.
de Almeida SR. Immunology of dermatophytosis. Mycopathologia. 2008;166:277–83.
Mignon B, Tabart J, Baldo A, et al. Immunization and dermatophytes. Curr Opin Infect Dis. 2008;21:134–40.
