Article (Scientific journals)
Reducing the global burden of HTLV-1 infection: An agenda for research and action
Willems, Luc; Hasegawa, Hideki; Accolla, Roberto et al.
2016In Antiviral Research, 137 (2017), p. 41-48
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Keywords :
HTLV-1; Vaccine; Oncogene; Retrovirus; Leukemia
Abstract :
[en] Even though an estimated 10e20 million people worldwide are infected with the oncogenic retrovirus, human T-lymphotropic virus type 1 (HTLV-1), its epidemiology is poorly understood, and little effort has been made to reduce its prevalence. In response to this situation, the Global Virus Network launched a taskforce in 2014 to develop new methods of prevention and treatment of HTLV-1 infection and promote basic research. HTLV-1 is the etiological agent of two life-threatening diseases, adult T-cell leukemia and HTLV-associated myelopathy/tropical spastic paraparesis, for which no effective therapy is currently available. Although the modes of transmission of HTLV-1 resemble those of the more familiar HIV-1, routine diagnostic methods are generally unavailable to support the prevention of new infections. In the present article, the Taskforce proposes a series of actions to expand epidemiological studies; increase research on mechanisms of HTLV-1 persistence, replication and pathogenesis; discover effective treatments; and develop prophylactic and therapeutic vaccines.
Disciplines :
Oncology
Author, co-author :
Willems, Luc  ;  Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.
Hasegawa, Hideki
Accolla, Roberto
Bangham, Charles
Bazarbachi, Ali
Bertazzoni, Umberto
Barbara de Freitas Carneiro-Proietti, Anna
Cheng, Hua
Chieco-Bianchi, Luigi
Ciminale, Vincenzo
Coelho-dos-Reis, Jordana
Esparza, Jose
Gallo, Robert C
Gessain, Antoine
Gotuzzo, Eduardo
Hall, William
Harford, Joseph
Hermine, Olivier
Jacobson, Steven
Macchi, Beatrice
Macpherson, Calum
Mahieux, Renaud
Matsuoka, Masao
Murphy, Edward
Peloponese, Jean-Marie
Simon, Viviana
Tagaya, Yutaka
Taylor, Graham P
Watanabe, Toshiki
Yamano, Yoshihisa
More authors (20 more) Less
Language :
English
Title :
Reducing the global burden of HTLV-1 infection: An agenda for research and action
Publication date :
11 November 2016
Journal title :
Antiviral Research
ISSN :
0166-3542
Publisher :
Elsevier, Amsterdam, Netherlands
Volume :
137
Issue :
2017
Pages :
41-48
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
the Interuniversity Attraction Poles (IAP)
Program “Virus-host interplay at the early phases of infection” BELVIR initiated by the Belgian Science Policy Office
AgricultureIsLife
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Télévie [BE]
BELSPO - Politique scientifique fédérale [BE]
Belgian Foundation Against Cancer [BE]
CAC - Centre anticancéreux près l'Université de Liège asbl [BE]
Fonds Léon Fredericq [BE]
ULiège. GxABT - Liège Université. Gembloux Agro-Bio Tech [BE]
ULg FSR - Université de Liège. Fonds spéciaux pour la recherche [BE]
Funding text :
The “Plan Cancer” of the Service Public Federal
Available on ORBi :
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