Reference : Concise Reviews: Regeneration in Mammalian Cochlea Hair Cells: Help from Supporting C...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Concise Reviews: Regeneration in Mammalian Cochlea Hair Cells: Help from Supporting Cells Transdifferentiation.
Franco, Benedicte [> >]
Malgrange, Brigitte mailto [Université de Liège > > GIGA - Neurosciences >]
Stem Cells
Yes (verified by ORBi)
United States
[en] Cell signaling ; Cellular proliferation ; Differentiation ; Progenitor cells
[en] It is commonly assumed that mammalian cochlear cells do not regenerate. Therefore, if hair cells are lost following an injury, no recovery could occur. However, during the first postnatal week, mice harbor some progenitor cells that retain the ability to give rise to new hair cells. These progenitor cells are in fact supporting cells. Upon hair cells loss, those cells are able to generate new hair cells both by direct transdifferentiation or following cell cycle re-entry and differentiation. However, this property of supporting cells is progressively lost after birth. Here, we review the molecular mechanisms that are involved in mammalian hair cell development and regeneration. Manipulating pathways used during development constitute good candidates for inducing hair cell regeneration after injury. Despite these promising studies, there is still no evidence for a recovery following hair cells loss in adult mammals. Stem Cells 2017.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
(c) 2017 AlphaMed Press.

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