Effet of immune modulation in relapsed peripheral T-cell lymphomas after allogeneic stem cell transplantation: a study by the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)

Mamez; Levy, V; Chevallier, P; Blaise, D; Vigouroux, S; Xhaard, A; Fegueux, N; Contentin, N; BEGUIN, Yves; Ifrah, N; Bulabois, CE; Suarez, F; Yakoub-Agha, I; Turlure, P; Deconink, E; Lamy, T; Cahn, J-Y; Huynh, A; Maury, S; Fornecker, L-M; Ouzegdouh, M; Bay, J-O; Guillerm, G; Maillard, N; Michallet, M; Malfuson, J-V; Bourhis, J-H; Rialland, F; Oumedaly, R; Jubert, C; Leblond, V; Boubaya, M; Mohty, M; Nguyen, S

doi:10.1038/bmt.2015.280

Article (Scientific journals)

Effet of immune modulation in relapsed peripheral T-cell lymphomas after allogeneic stem cell transplantation: a study by the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)

Mamez; Levy, V; Chevallier, P et al.

2016 • In Bone Marrow Transplantation, 51, p. 358-364

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https://hdl.handle.net/2268/205987

DOI
10.1038/bmt.2015.280

PubMed
26595076

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Abstract :

[en] Peripheral T-cell lymphoma carries a poor prognosis. To document a possible graft-versus-lymphoma effect in this setting, we evaluated the impact of immunomodulation in 63 patients with peripheral T-cell lymphoma who relapsed after allogeneic transplant in 27 SFGM-TC centers. Relapse occurred after a median of 2.8 months. Patients were then treated with nonimmunologic strategies (chemotherapy, radiotherapy) and/or immune modulation (donor lymphocyte infusions (DLI) and/or discontinuation of immunosuppressive therapy). Median overall survival (OS) after relapse was 6.1 months (DLI group: 23.6 months, non-DLI group: 3.6 months). Among the 14 patients who received DLI, 9 responded and 2 had stable disease. Among the remaining 49 patients, a complete response accompanied by extensive chronic GvHD was achieved in two patients after tapering of immunosuppressive drugs. Thirty patients received radio-chemotherapy, with an overall response rate of 50%. In multivariate analysis, chronic GvHD (odds ratio: 11.25 (2.68–48.21), P = 0.0009) and skin relapse (odds ratio: 4.15 (1.04–16.50), P = 0.043) were associated with a better response to treatment at relapse. In a time-dependent analysis, the only factor predictive of OS was the time from transplantation to relapse (hazards ratio: 0.33 (0.17–0.640), P = 0.0009). This large series provides encouraging evidence of a true GvL effect in this disease.

Disciplines :

Hematology

Author, co-author :

Mamez

Levy, V

Chevallier, P

Blaise, D

Vigouroux, S

Xhaard, A

Fegueux, N

Contentin, N

BEGUIN, Yves ; Centre Hospitalier Universitaire de Liège - CHU > Service d'hématologie clinique

Ifrah, N

More authors (24 more)

Language :

English

Title :

Publication date :

2016

Journal title :

Bone Marrow Transplantation

ISSN :

0268-3369

eISSN :

1476-5365

Publisher :

Nature Publishing Group, London, United Kingdom

Volume :

Pages :

358-364

Peer reviewed :

Peer Reviewed verified by ORBi

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since 26 January 2017

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