Article (Scientific journals)
Effet of immune modulation in relapsed peripheral T-cell lymphomas after allogeneic stem cell transplantation: a study by the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
Mamez; Levy, V; Chevallier, P et al.
2016In Bone Marrow Transplantation, 51, p. 358-364
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Abstract :
[en] Peripheral T-cell lymphoma carries a poor prognosis. To document a possible graft-versus-lymphoma effect in this setting, we evaluated the impact of immunomodulation in 63 patients with peripheral T-cell lymphoma who relapsed after allogeneic transplant in 27 SFGM-TC centers. Relapse occurred after a median of 2.8 months. Patients were then treated with nonimmunologic strategies (chemotherapy, radiotherapy) and/or immune modulation (donor lymphocyte infusions (DLI) and/or discontinuation of immunosuppressive therapy). Median overall survival (OS) after relapse was 6.1 months (DLI group: 23.6 months, non-DLI group: 3.6 months). Among the 14 patients who received DLI, 9 responded and 2 had stable disease. Among the remaining 49 patients, a complete response accompanied by extensive chronic GvHD was achieved in two patients after tapering of immunosuppressive drugs. Thirty patients received radio-chemotherapy, with an overall response rate of 50%. In multivariate analysis, chronic GvHD (odds ratio: 11.25 (2.68–48.21), P = 0.0009) and skin relapse (odds ratio: 4.15 (1.04–16.50), P = 0.043) were associated with a better response to treatment at relapse. In a time-dependent analysis, the only factor predictive of OS was the time from transplantation to relapse (hazards ratio: 0.33 (0.17–0.640), P = 0.0009). This large series provides encouraging evidence of a true GvL effect in this disease.
Disciplines :
Hematology
Author, co-author :
Mamez
Levy, V
Chevallier, P
Blaise, D
Vigouroux, S
Xhaard, A
Fegueux, N
Contentin, N
BEGUIN, Yves  ;  Centre Hospitalier Universitaire de Liège - CHU > Service d'hématologie clinique
Ifrah, N
Bulabois, CE
Suarez, F
Yakoub-Agha, I
Turlure, P
Deconink, E
Lamy, T
Cahn, J-Y
Huynh, A
Maury, S
Fornecker, L-M
Ouzegdouh, M
Bay, J-O
Guillerm, G
Maillard, N
Michallet, M
Malfuson, J-V
Bourhis, J-H
Rialland, F
Oumedaly, R
Jubert, C
Leblond, V
Boubaya, M
Mohty, M
Nguyen, S
More authors (24 more) Less
Language :
English
Title :
Effet of immune modulation in relapsed peripheral T-cell lymphomas after allogeneic stem cell transplantation: a study by the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
Publication date :
2016
Journal title :
Bone Marrow Transplantation
ISSN :
0268-3369
eISSN :
1476-5365
Publisher :
Nature Publishing Group, London, United Kingdom
Volume :
51
Pages :
358-364
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 26 January 2017

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