Reference : Mechanotransductive cascade of Myo-II-dependent mesoderm and endoderm invaginations i...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Physics
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
http://hdl.handle.net/2268/205900
Mechanotransductive cascade of Myo-II-dependent mesoderm and endoderm invaginations in embryo gastrulation
English
Mitrossilis, Démosthène [> >]
Röper, Jens-Christian [> >]
Roy, Damien Le [> >]
Driquez, Benjamin [> >]
Michel, Aude [> >]
Ménager, Christine [> >]
Shaw, Gorky mailto [Université de Liège > Département de physique > Physique expérimentale des matériaux nanostructurés >]
Denmat, Simon Le [> >]
Ranno, Laurent [> >]
Dumas-Bouchiat, Frédéric [> >]
Dempsey, Nora M. [> >]
Farge, Emmanuel [> >]
23-Jan-2017
Nature Communications
Nature Publishing Group
8
13883
Yes (verified by ORBi)
International
2041-1723
[en] Animal development consists of a cascade of tissue differentiation and shape change. Associated mechanical signals regulate tissue differentiation. Here we demonstrate that endogenous mechanical cues also trigger biochemical pathways, generating the active morphogenetic movements shaping animal development through a mechanotransductive cascade of Myo-II medio-apical stabilization. To mimic physiological tissue deformation with a cell scale resolution, liposomes containing magnetic nanoparticles are injected into embryonic epithelia and submitted to time-variable forces generated by a linear array of micrometric soft magnets. Periodic magnetically induced deformations quantitatively phenocopy the soft mechanical endogenous snail-dependent apex pulsations, rescue the medio-apical accumulation of Rok, Myo-II and subsequent mesoderm invagination lacking in sna mutants, in a Fog-dependent mechanotransductive process. Mesoderm invagination then activates Myo-II apical accumulation, in a similar Fog-dependent mechanotransductive process, which in turn initiates endoderm invagination. This reveals the existence of a highly dynamic self-inductive cascade of mesoderm and endoderm invaginations, regulated by mechano-induced medio-apical stabilization of Myo-II.
http://hdl.handle.net/2268/205900
10.1038/ncomms13883
https://dx.doi.org/10.1038/ncomms13883

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Mitrossilis_et_al-2017-Nature_Communications.pdfPublisher postprint2.89 MBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.