Article (Scientific journals)
A vertebrate specific and essential role for sp7/osterix in osteogenesis revealed by gene knock-out in the teleost medaka.
Yu, T; Graf, M; Renn, Jörg et al.
2017In Development, 144 (2), p. 265-271
Peer reviewed
 

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Keywords :
osteoblasts; osteogenesis; skeleton; bone modelling; medaka; sp7; osterix
Abstract :
[en] Sp7/osterix (osx) encodes a zinc-finger transcription factor that controls osteoblast differentiation in mammals. Although identified in all vertebrate lineages, its role in non-mammalian bone formation remains elusive. Here we show that an osx mutation in medaka results in severe bone defects and larval lethality. Pre-osteoblasts fail to differentiate leading to severe intramembranous and perichondral ossification defects. The notochord sheath mineralizes normally supporting the idea of an osteoblast-independent mechanism for teleost vertebral centra formation. This study establishes a key role for Sp7/Osx for bone formation also in a non-mammalian species, and reveals conserved and non-conserved features in vertebrate bone formation.
Disciplines :
Genetics & genetic processes
Author, co-author :
Yu, T
Graf, M
Renn, Jörg ;  Université de Liège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Schartl, M
Larionova, D
Huysseune, A
Witten, PE
Winkler, C
Language :
English
Title :
A vertebrate specific and essential role for sp7/osterix in osteogenesis revealed by gene knock-out in the teleost medaka.
Publication date :
2017
Journal title :
Development
ISSN :
1011-6370
eISSN :
1461-7072
Publisher :
Palgrave Macmillan, Hampshire, United Kingdom
Volume :
144
Issue :
2
Pages :
265-271
Peer reviewed :
Peer reviewed
Available on ORBi :
since 19 January 2017

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