Sequence and expression analysis of rainbow trout CXCR2, CXCR3a and CXCR3b aids interpretation of lineage-specific conversion, loss and expansion of these receptors during vertebrate evolution.
Xu, Qiaoqing; Li, Ronggai; Mira Monte, Milenaet al.
2014 • In Developmental and Comparative Immunology, 45 (2), p. 201-13
Amino Acid Sequence; Animals; Evolution, Molecular; Fish Diseases/immunology/microbiology/parasitology; Fish Proteins/genetics/immunology; Head Kidney/immunology; Humans; Infection/immunology/microbiology/parasitology/veterinary; Macrophages/immunology; Molecular Sequence Data; Oncorhynchus mykiss/genetics/immunology; Organ Specificity; Phylogeny; Receptors, CXCR/genetics/immunology; Sequence Alignment; CXCR2; CXCR3a; CXCR3b; Evolution; Expression; Rainbow trout
Abstract :
[en] The chemokine receptors CXCR1-3 bind to 11 chemokines (CXCL1-11) that are clustered on the same chromosome in mammals but are largely missing in ray-finned fish. A second CXCR1/2, and a CXCR3a and CXCR3b gene have been cloned in rainbow trout. Analysis of CXCR1-R3 genes in lobe-finned fish, ray-finned fish and tetrapod genomes revealed that the teleostomian ancestor likely possessed loci containing both CXCR1 and CXCR2, and CXCR3a and CXCR3b. Based on this synteny analysis the first trout CXCR1/2 gene was renamed CXCR1, and the new gene CXCR2. The CXCR1/R2 locus was shown to have further expanded in ray-finned fish. In relation to CXCR3, mammals appear to have lost CXCR3b and birds both CXCR3a and CXCR3b during evolution. Trout CXCR1-R3 have distinct tissue expression patterns and are differentially modulated by PAMPs, proinflammatory cytokines and infections. They are highly expressed in macrophages and neutrophils, with CXCR1 and CXCR2 also expressed in B-cells.
Sequence and expression analysis of rainbow trout CXCR2, CXCR3a and CXCR3b aids interpretation of lineage-specific conversion, loss and expansion of these receptors during vertebrate evolution.
Publication date :
2014
Journal title :
Developmental and Comparative Immunology
ISSN :
0145-305X
Publisher :
Elsevier, United Kingdom
Volume :
45
Issue :
2
Pages :
201-13
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.
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