DRUG DELIVERY NANOCARRIERS TO CROSS OF THE BLOOD-BRAIN BARRIER

Palazzo, Claudio; Karim, Reatul; Evrard, Brigitte; Piel, Géraldine

doi:10.1016/B978-0-323-42866-8.00001-0

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DRUG DELIVERY NANOCARRIERS TO CROSS OF THE BLOOD-BRAIN BARRIER

Palazzo, Claudio; Karim, Reatul; Evrard, Brigitte et al.

2016 • In Grumezescu, Alex (Ed.) Nanobiomaterials in drug delivery

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https://hdl.handle.net/2268/204145

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10.1016/B978-0-323-42866-8.00001-0

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Keywords :

Nanoparticle; Blood-Brain Barrier; Liposome; Solid Lipid Nanocapsule; Polymeric Nanoparticles

Abstract :

[en] Blood-brain barrier (BBB) is a brain protective structure composed by endothelial cells, astrocytes and pericytes characterized by specific transport systems expressed on their surface. Moreover, the tight junctions, in the paracellular space, and the adherens junctions, in the basolateral space of the endothelial cells create a physical barrier hardly crossable from the most part of common drugs. Despite the BBB is vital for the central nervous system (CNS), it restricts drug delivery to this tissue. To overcome this obstacle many drug delivery systems (DDS) have been developed. Polymeric nanocarriers, solid lipid nanocarriers (SLN) and liposomes are developed to deliver drugs otherwise not able to pass the BBB, due to their physico-chemical characteristics. Besides their capacity to pass biological barriers, the potential advantages of nanocarriers are their capability to load a high quantity of drug with low cytotoxicity.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Palazzo, Claudio ; Université de Liège > Département de pharmacie > Département de pharmacie

Karim, Reatul ; Université de Liège > Département de pharmacie > Pharmacie galénique

Evrard, Brigitte ; Université de Liège > Département de pharmacie > Pharmacie galénique

Piel, Géraldine ; Université de Liège > Département de pharmacie > Pharmacie galénique

Language :

English

Title :

DRUG DELIVERY NANOCARRIERS TO CROSS OF THE BLOOD-BRAIN BARRIER

Publication date :

2016

Main work title :

Nanobiomaterials in drug delivery

Publishing director :

Grumezescu, Alex

Publisher :

Elsevier

Available on ORBi :

since 08 December 2016

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