This website uses cookies

The University of Liège wishes to use cookies or trackers to store and access your personal data, to perform audience measurement. Some cookies are necessary for the website to function. Cookie policy.

No full text
Contribution to collective works (Parts of books)
DRUG DELIVERY NANOCARRIERS TO CROSS OF THE BLOOD-BRAIN BARRIER
Palazzo, Claudio; Karim, Reatul; Evrard, Brigitte et al.
2016In Grumezescu, Alex (Ed.) Nanobiomaterials in drug delivery
 

Files


Full Text
No document available.

Send to



Details



Keywords :
Nanoparticle; Blood-Brain Barrier; Liposome; Solid Lipid Nanocapsule; Polymeric Nanoparticles
Abstract :
[en] Blood-brain barrier (BBB) is a brain protective structure composed by endothelial cells, astrocytes and pericytes characterized by specific transport systems expressed on their surface. Moreover, the tight junctions, in the paracellular space, and the adherens junctions, in the basolateral space of the endothelial cells create a physical barrier hardly crossable from the most part of common drugs. Despite the BBB is vital for the central nervous system (CNS), it restricts drug delivery to this tissue. To overcome this obstacle many drug delivery systems (DDS) have been developed. Polymeric nanocarriers, solid lipid nanocarriers (SLN) and liposomes are developed to deliver drugs otherwise not able to pass the BBB, due to their physico-chemical characteristics. Besides their capacity to pass biological barriers, the potential advantages of nanocarriers are their capability to load a high quantity of drug with low cytotoxicity.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Palazzo, Claudio ;  Université de Liège > Département de pharmacie > Département de pharmacie
Karim, Reatul ;  Université de Liège > Département de pharmacie > Pharmacie galénique
Evrard, Brigitte  ;  Université de Liège > Département de pharmacie > Pharmacie galénique
Piel, Géraldine  ;  Université de Liège > Département de pharmacie > Pharmacie galénique
Language :
English
Title :
DRUG DELIVERY NANOCARRIERS TO CROSS OF THE BLOOD-BRAIN BARRIER
Publication date :
2016
Main work title :
Nanobiomaterials in drug delivery
Publishing director :
Grumezescu, Alex
Publisher :
Elsevier
Available on ORBi :
since 08 December 2016

Statistics


Number of views
167 (7 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
30
Scopus citations®
without self-citations
22
OpenCitations
 
9
OpenAlex citations
 
29

publications
0
supporting
0
mentioning
0
contrasting
0
Smart Citations
0
0
0
0
Citing PublicationsSupportingMentioningContrasting
View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

Bibliography


Similar publications



Sorry the service is unavailable at the moment. Please try again later.
Contact ORBi