Reference : 68Ga and 188Re Starch-Based Microparticles as Theranostic Tool for the Hepatocellular...
Scientific journals : Article
Human health sciences : Oncology
http://hdl.handle.net/2268/203803
68Ga and 188Re Starch-Based Microparticles as Theranostic Tool for the Hepatocellular Carcinoma: Radiolabeling and Preliminary In Vivo Rat Studies
English
Verger, Elise mailto [Université de Liège - ULiège > > > Doct. sc. bioméd. & pharma. (paysage)]
Drion, Pierre mailto [Université de Liège > Département des sciences biomédicales et précliniques > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim. >]
MEFFRE, Geneviève mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service médical de médecine nucléaire et imagerie onco >]
BERNARD, Claire mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service médical de médecine nucléaire et imagerie onco >]
Duwez, Luc mailto [Université de Liège > > GIGA-R : Services généraux de l'Université >]
Lepareur, Nicolas mailto [> >]
Couturier, Olivier mailto [> >]
Hindré, François mailto [> >]
HUSTINX, Roland mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service médical de médecine nucléaire et imagerie onco >]
Lacoeuille, Franck mailto [> >]
14-Oct-2016
PLoS ONE
Public Library of Science
Yes (verified by ORBi)
International
1932-6203
San Franscisco
CA
[en] Gallium 68 ; Rhenium 68 ; Microparticles ; Theranostic Tool ; Hepatocellular Carcinoma ; Radiolabeling ; Rat ; Starch-Based Microparticles ; (SBMP
[en] This work aims to develop, validate and optimize the radiolabeling of Starch-Based Microparticles (SBMP) by 188Re and 68Ga in the form of ready-to-use radiolabeling kits, the ultimate goal being to obtain a unique theranostic vector for the treatment of Hepatocellular Carcinoma.
METHODS: Optimal labeling conditions and composition of freeze-dried kits were defined by monitoring the radiochemical purity while varying several parameters. In vitro stability studies were carried out, as well as an in vivo biodistribution as a preliminary approach with the intra-arterial injection of 68Ga radiolabeled SBMP into the hepatic artery of DENA-induced rats followed by PET/CT imaging.
RESULTS: Kits were optimized for 188Re and 68Ga with high and stable radiochemical purity (>95% and >98% respectively). The in vivo preliminary study was successful with more than 95% of activity found in the liver and mostly in the tumorous part.
CONCLUSION: SBMP are a promising theranostic agent for the Selective Internal Radiation Therapy of Hepatocellular carcinoma
This work has been supported by a grant from the Ministère de l'Enseignement SupeÂrieur et de la Recherche in the frame of the Erasmus Mundus Joint Doctorate NanoFar program (EV); and has been supported in part by a grant from the French National Agency for Research called "Investissements d'Avenir" Labex IRON n°ANR-11- LABX-0018-01 (FH, FL, OC). This work was authorized by Laboratoires Cyclopharma, through patent WO2009013358. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Researchers ; Professionals
http://hdl.handle.net/2268/203803
10.1371/journal.pone.0164626
https://www.ncbi.nlm.nih.gov/pubmed/27741267

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