[en] Endocrine cells of the digestive tract include pancreatic cells clustered in the islets of Langerhans and the enteroendocrine cells, scattered throughout the digestive epithelium. Notch pathway plays a crucial role in endocrine cell fate determination and mediates cell fate decisions.
The goal of this project is to decipher the molecular cascade triggered by Notch signaling that controls the endocrine cell differentiation in the digestive system. The targets of Notch signaling are usually members of the bHLH family and more precisely of the Achaete scute-like (Ascl) family or of the atonal related proteins (ARP) family. In this study, we searched for all ARP and Ascl factors expressed in the endocrine lineage of the pancreas and in the gastrointestinal tract in zebrafish.
Research center :
Giga-Development and Stem Cells - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Stern, David ; Université de Liège - ULiège > Doct. sc. (bioch., biol. mol.&cell., bioinf.&mod.-Bologne)
Voz, Marianne ; Université de Liège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Language :
English
Title :
Enteroendocrine cells ontogenesis in zebrafish
Alternative titles :
[en] Ontogenèse des cellules entéroendocrines chez le zebrafish
Publication date :
04 July 2012
Number of pages :
84X119 cm
Event name :
14ème congrès européen d'ichtyologie
Event organizer :
ulg
Event date :
du 3 juillet 2012 au 8 juillet 2012
Audience :
International
Name of the research project :
fonction des facteurs ARP/ASCL dans la différenciation des cellules sécrétrices du tractus gastrointestinal chez le zebrafish
Funders :
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
