Reference : Enteroendocrine cells ontogenesis in zebrafish
Scientific congresses and symposiums : Poster
Life sciences : Biochemistry, biophysics & molecular biology
Enteroendocrine cells ontogenesis in zebrafish
[en] Ontogenèse des cellules entéroendocrines chez le zebrafish
Stern, David mailto [Université de Liège - ULiège > > > Doct. sc. (bioch., biol. mol.&cell., bioinf.&mod.-Bologne)]
Voz, Marianne mailto [Université de Liège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
84X119 cm
14ème congrès européen d'ichtyologie
du 3 juillet 2012 au 8 juillet 2012
[en] enteroendocrine ; proneural ; zebrafish
[en] Endocrine cells of the digestive tract include pancreatic cells clustered in the islets of Langerhans and the enteroendocrine cells, scattered throughout the digestive epithelium. Notch pathway plays a crucial role in endocrine cell fate determination and mediates cell fate decisions.
The goal of this project is to decipher the molecular cascade triggered by Notch signaling that controls the endocrine cell differentiation in the digestive system. The targets of Notch signaling are usually members of the bHLH family and more precisely of the Achaete scute-like (Ascl) family or of the atonal related proteins (ARP) family. In this study, we searched for all ARP and Ascl factors expressed in the endocrine lineage of the pancreas and in the gastrointestinal tract in zebrafish.  
Giga-Development and Stem Cells
Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA
fonction des facteurs ARP/ASCL dans la différenciation des cellules sécrétrices du tractus gastrointestinal chez le zebrafish

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