Reference : Fibroblast growth factor 23 in acute burn patients: Novel insights from an intact-for...
Scientific journals : Article
Human health sciences : Laboratory medicine & medical technology
http://hdl.handle.net/2268/201785
Fibroblast growth factor 23 in acute burn patients: Novel insights from an intact-form assay.
English
ROUSSEAU, Anne-Françoise mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs généraux >]
SOUBERBIELLE, Jean-Claude []
DELANAYE, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service de néphrologie >]
Damas, Pierre mailto [Université de Liège > Département des sciences cliniques > Anesthésie et réanimation >]
Cavalier, Etienne mailto [Université de Liège > Département de pharmacie > Chimie médicale >]
2016
Burns: Journal of the International Society for Burn Injuries
Elsevier
Yes (verified by ORBi)
International
0305-4179
1879-1409
New York
NY
[en] Burns ; FGF23 ; Iron ; Phosphate ; Vitamin D
[en] INTRODUCTION: Fibroblast growth factor 23 (FGF23) is a key regulator in phosphate and vitamin D metabolism When measured with c-terminal assay, it has been shown to be increased following burn. Progress in understanding FGF23 physiology has emphasized the importance of assessing the intact form of FGF23. METHODS: The present cohort study is a complementary analysis of a previously published work. Patients >18 years, admitted within 24h after injury with burn surface area (BSA) >10% were included. C-terminal (c-term) and intact (i) FGF23 assay were performed at admission and every week during 4 weeks of follow-up. Inflammation and iron status were assessed at the same time points. RESULTS: Twenty patients were initially included and 12 were followed until day 28. The c-term FGF23 tended to gradually increase during the 4 weeks of follow-up while iFGF23 was quite stable into normal ranges. Iron status showed a typical inflammatory profile. C-term FGF23 was significantly positively correlated with c-reactive protein (CRP) and negatively correlated with iron levels. iFGF23 was not correlated with CRP or iron. CONCLUSION: FGF23 status following burn is characterized by a dissociation between c-term FGF23 and iFGF23. The hypothesis of an increased cleavage may be raised. Respective role of inflammation and iron levels in such deregulation need to be specified. Both c-term and intact assays should be performed in further studies aiming to increase knowledge on FGF23 regulation and effects in burn patients.
http://hdl.handle.net/2268/201785
10.1016/j.burns.2016.01.024
Copyright (c) 2016 Elsevier Ltd and ISBI. All rights reserved.

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