Article (Scientific journals)
Fibroblast growth factor 23 in acute burn patients: Novel insights from an intact-form assay.
ROUSSEAU, Anne-Françoise; SOUBERBIELLE, Jean-Claude; DELANAYE, Pierre et al.
2016In Burns: Journal of the International Society for Burn Injuries
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Keywords :
Burns; FGF23; Iron; Phosphate; Vitamin D
Abstract :
[en] INTRODUCTION: Fibroblast growth factor 23 (FGF23) is a key regulator in phosphate and vitamin D metabolism When measured with c-terminal assay, it has been shown to be increased following burn. Progress in understanding FGF23 physiology has emphasized the importance of assessing the intact form of FGF23. METHODS: The present cohort study is a complementary analysis of a previously published work. Patients >18 years, admitted within 24h after injury with burn surface area (BSA) >10% were included. C-terminal (c-term) and intact (i) FGF23 assay were performed at admission and every week during 4 weeks of follow-up. Inflammation and iron status were assessed at the same time points. RESULTS: Twenty patients were initially included and 12 were followed until day 28. The c-term FGF23 tended to gradually increase during the 4 weeks of follow-up while iFGF23 was quite stable into normal ranges. Iron status showed a typical inflammatory profile. C-term FGF23 was significantly positively correlated with c-reactive protein (CRP) and negatively correlated with iron levels. iFGF23 was not correlated with CRP or iron. CONCLUSION: FGF23 status following burn is characterized by a dissociation between c-term FGF23 and iFGF23. The hypothesis of an increased cleavage may be raised. Respective role of inflammation and iron levels in such deregulation need to be specified. Both c-term and intact assays should be performed in further studies aiming to increase knowledge on FGF23 regulation and effects in burn patients.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
ROUSSEAU, Anne-Françoise  ;  Centre Hospitalier Universitaire de Liège - CHU > Service des soins intensifs généraux
SOUBERBIELLE, Jean-Claude
DELANAYE, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > Service de néphrologie
Damas, Pierre ;  Université de Liège > Département des sciences cliniques > Anesthésie et réanimation
Cavalier, Etienne  ;  Université de Liège > Département de pharmacie > Chimie médicale
Language :
English
Title :
Fibroblast growth factor 23 in acute burn patients: Novel insights from an intact-form assay.
Publication date :
2016
Journal title :
Burns: Journal of the International Society for Burn Injuries
ISSN :
0305-4179
eISSN :
1879-1409
Publisher :
Elsevier, New York, United States - New York
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2016 Elsevier Ltd and ISBI. All rights reserved.
Available on ORBi :
since 14 September 2016

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