Reference : Oxytocin in survivors of childhood-onset craniopharyngioma
Scientific journals : Article
Human health sciences : Neurology
Human health sciences : Endocrinology, metabolism & nutrition
Oxytocin in survivors of childhood-onset craniopharyngioma
Daubenbüchel, Anna mailto [Klinikum Oldenburg AöR, Germany > Pediatrics > > >]
Hoffmann, Anika mailto [Klinikum Oldenburg AöR, Germany > Pediatrics > > >]
Eveslage, Maria mailto [University of Münster, Germany > Institute of Bioatatistics and Clinical Research > > >]
Özyurt, Jale mailto [University of Oldenburg, Germany > Biological Psychology > > >]
Lohle, Kristin [Klinikum Oldenburg AöR, Germany > Pediatrics > > >]
Reichel, Julia mailto [Klinikum Oldenburg AöR, Germany > Pediatrics > > >]
Thiel, Christiane M. mailto [University of Oldenburg, Germany > Research Center Neurosensory Science > > >]
Martens, Henri mailto [Université de Liège > > Centre d'immunologie >]
Geenen, Vincent mailto [Université de Liège > > Centre d'immunologie >]
Müller, Hermann L. mailto [Klinikum Oldenburg AöR, Germany > Pediatrics > > >]
Humana Press
Yes (verified by ORBi)
[en] Craniopharyngioma ; Hypothalamus ; Oxytocin ; Behavior ; Obesity
[en] Quality of survival of childhood-onset cranio- pharyngioma patients is frequently impaired by hypotha- lamic involvement or surgical lesions sequelae such as obesity and neuropsychological deficits. Oxytocin, a pep- tide hormone produced in the hypothalamus and secreted by posterior pituitary gland, plays a major role in regula- tion of behavior and body composition. In a cross- sectional study, oxytocin saliva concentrations were ana- lyzed in 34 long-term craniopharyngioma survivors with and without hypothalamic involvement or treatment- related damage, recruited in the German Childhood Cra- niopharyngioma Registry, and in 73 healthy controls, attending the Craniopharyngioma Support Group Meeting 2014. Oxytocin was measured in saliva of craniophar- yngioma patients and controls before and after standar- dized breakfast and associations with gender, body mass index, hypothalamic involvement, diabetes insipidus, and irradiation were analyzed. Patients with preoperative hypothalamic involvement showed similar oxytocin levels compared to patients without hypothalamic involvement and controls. However, patients with surgical hypotha- lamic lesions grade 1 (anterior hypothalamic area) pre- sented with lower levels (p = 0.017) of oxytocin under fasting condition compared to patients with surgical lesion of posterior hypothalamic areas (grade 2) and patients without hypothalamic lesions (grade 0). Craniophar- yngioma patients’ changes in oxytocin levels before and after breakfast correlated (p = 0.02) with their body mass index. Craniopharyngioma patients continue to secrete oxytocin, especially when anterior hypothalamic areas are not involved or damaged, but oxytocin shows less varia- tion due to nutrition. Oxytocin supplementation should be explored as a therapeutic option in craniopharyngioma patients with hypothalamic obesity and/or behavioral pathologies due to lesions of specific anterior hypotha- lamic areas. Clinical trial number: KRANIOPHAR- YNGEOM 2000/2007(NCT00258453; NCT01272622).
German Childhood Cancer Foundation
Researchers ; Professionals ; Students

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