[en] BACKGROUND: There is evident benefit in terms of reduced aneurysm related mortality from screening programmes of abdominal aortic aneurysm (AAA) in men aged 65 and more. Recent studies in UK and Sweden have shown a decline of the prevalence of AAA in the general population. Current screening policies (e.g. men aged 65-74 years) however do not account for ageing and increased life expectancy of western populations. This study investigated AAA detection by extending the target population to older age groups (75-85 years). METHODS: AAA screening was conducted in the County of Chaudfontaine (Liege, Belgium) on the population of elderly (N=3,054). The participation rate was 36%. The 1,101 participants (722 men aged 65-85 and 379 women aged 74-85 years) were examined by ultrasound (US) scan. AAA was defined as an infrarenal aortic outer-outer diameter of at least 3 cm. Demographics, clinical parameters and risk factors were also recorded. AAA prevalence was estimated and patients with and without AAA were compared by logistic regression. RESULTS: The overall AAA prevalence was 3.6% (n=40). In female participants, AAA prevalence was low (1.3%). In men, it amounted 2.7% in the 65-74 age group but rose to 7.3% in the age-extended group (75-85 years). Further in addition to age, height, current smoking, history of coronary artery disease, hypercholesterolemia, peripheral artery disease of the lower limbs and varicose veins were significantly associated with the presence of AAA. CONCLUSION: These preliminary findings, based on a representative sample of the elderly population of the Liege region, support the idea that current AAA screening policies should be updated to cover an increasingly ageing population. The presence of varicose veins as a potential risk factor for AAA should also be considered during screening.
Disciplines :
Génétique & processus génétiques Chirurgie
Auteur, co-auteur :
MAKRYGIANNIS, Georgios ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdo, sénologique, endocrine et de transplantation
Labalue, Philippe
Erpicum, Marie ; Université de Liège > Département des sciences de la santé publique > Département des sciences de la santé publique
Schlitz, Martin
SEIDEL, Laurence ; Centre Hospitalier Universitaire de Liège - CHU > Service des informations médico économiques (SIME)
El Hachemi, Mounia
GANGOLF, Marjorie ; Centre Hospitalier Universitaire de Liège - CHU > Service des informations médico économiques (SIME)
Albert, Adelin ; Université de Liège > Département des sciences de la santé publique > Département des sciences de la santé publique
Defraigne, Jean-Olivier ; Université de Liège > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique
Lindholt, Jes S.
Sakalihasan, Natzi ; Université de Liège > Département des sciences cliniques > Biologie pathologique des parois artérielles
Langue du document :
Anglais
Titre :
Extending abdominal aortic aneurysm detection to older age groups: preliminary results from the Liege screening programme.
Date de publication/diffusion :
2016
Titre du périodique :
Annals of Vascular Surgery
ISSN :
0890-5096
eISSN :
1615-5947
Maison d'édition :
Springer, New York, Etats-Unis - New York
Peer reviewed :
Peer reviewed vérifié par ORBi
Commentaire :
Copyright (c) 2016 Elsevier Inc. All rights reserved.
1 Thompson, S.G., Ashton, H.A., Gao, L., et al. Screening men for abdominal aortic aneurysm: 10 year mortality and cost effectiveness results from the randomised Multicentre Aneurysm Screening Study. BMJ, 338, 2009, b2307.
2 Lindholt, J.S., Sorensen, J., Sogaard, R., et al. Long-term benefit and cost-effectiveness analysis of screening for abdominal aortic aneurysms from a randomized controlled trial. Br J Surg 97 (2010), 826–834.
3 Norman, P.E., Jamrozik, K., Lawrence-Brown, M.M., et al. Population based randomised controlled trial on impact of screening on mortality from abdominal aortic aneurysm. BMJ, 329, 2004, 1259.
4 Scott, R.A., Wilson, N.M., Ashton, H.A., et al. Influence of screening on the incidence of ruptured abdominal aortic aneurysm: 5-year results of a randomized controlled study. Br J Surg 82 (1995), 1066–1070.
5 Scott, R.A., Bridgewater, S.G., Ashton, H.A., Randomized clinical trial of screening for abdominal aortic aneurysm in women. Br J Surg 89 (2002), 283–285.
6 Wanhainen, A., Lundkvist, J., Bergqvist, D., et al. Cost-effectiveness of screening women for abdominal aortic aneurysm. J Vasc Surg 43 (2006), 908–914 discussion 14.
7 Go, A.S., Mozaffarian, D., Roger, V.L., et al. Heart disease and stroke statistics–2014 update: a report from the American Heart Association. Circulation 129 (2014), e28–e292.
8 Makrygiannis, G., Courtois, A., Drion, P., et al. Sex differences in abdominal aortic aneurysm: the role of sex hormones. Ann Vasc Surg 28 (2014), 1946–1958.
9 Conway, A.M., Malkawi, A.H., Hinchliffe, R.J., et al. First-year results of a national abdominal aortic aneurysm screening programme in a single centre. Br J Surg 99 (2012), 73–77.
10 The North East of England Abdominal Aortic Aneurysm Screening Programme. Annual Report 2013-2014. Available at: http://aaa.screening.nhs.uk/getdata.php?id=1665. Accessed June 3, 2015.
11 Svensjo, S., Bjorck, M., Wanhainen, A., Current prevalence of abdominal aortic aneurysm in 70-year-old women. Br J Surg 100 (2013), 367–372.
12 Hager, J., Lanne, T., Carlsson, P., et al. Lower prevalence than expected when screening 70-year-old men for abdominal aortic aneurysm. Eur J Vasc Endovasc Surg 46 (2013), 453–459.
13 Svensjo, S., Bjorck, M., Wanhainen, A., Editor's choice: five-year outcomes in men screened for abdominal aortic aneurysm at 65 years of age: a population-based cohort study. Eur J Vasc Endovasc Surg 47 (2014), 37–44.
14 Svensjo, S., Mani, K., Bjorck, M., et al. Screening for abdominal aortic aneurysm in 65-year-old men remains cost-effective with contemporary epidemiology and management. Eur J Vasc Endovasc Surg 47 (2014), 357–365.
15 Sogaard, R., Laustsen, J., Lindholt, J.S., Cost effectiveness of abdominal aortic aneurysm screening and rescreening in men in a modern context: evaluation of a hypothetical cohort using a decision analytical model. BMJ, 345, 2012, e4276.
16 Barba, A., Vega de Ceniga, M., Estallo, L., et al. Prevalence of abdominal aortic aneurysm is still high in certain areas of southern Europe. Ann Vasc Surg 27 (2013), 1068–1073.
17 Palombo, D., Lucertini, G., Pane, B., et al. District-based abdominal aortic aneurysm screening in population aged 65 years and older. J Cardiovasc Surg (Torino) 51 (2010), 777–782.
18 Howard, D.P., Banerjee, A., Fairhead, J.F., et al. Age-specific incidence, risk factors and outcome of acute abdominal aortic aneurysms in a defined population. Br J Surg 102 (2015), 907–915.
19 Chiu, K.W., Ling, L., Tripathi, V., et al. Ultrasound measurement for abdominal aortic aneurysm screening: a direct comparison of the three leading methods. Eur J Vasc Endovasc Surg 47 (2014), 367–373.
20 Webster, M.W., Ferrell, R.E., St Jean, P.L., et al. Ultrasound screening of first-degree relatives of patients with an abdominal aortic aneurysm. J Vasc Surg 13 (1991), 9–13 discussion -4.
21 Ashton, H.A., Buxton, M.J., Day, N.E., et al. The Multicentre Aneurysm Screening Study (MASS) into the effect of abdominal aortic aneurysm screening on mortality in men: a randomised controlled trial. Lancet 360 (2002), 1531–1539.
22 Lindholt, J.S., Juul, S., Fasting, H., et al. Screening for abdominal aortic aneurysms: single centre randomised controlled trial. BMJ, 330, 2005, 750.
23 Svensjo, S., Bjorck, M., Gurtelschmid, M., et al. Low prevalence of abdominal aortic aneurysm among 65-year-old Swedish men indicates a change in the epidemiology of the disease. Circulation 124 (2011), 1118–1123.
24 Laws, C., Eastman, J., Screening for abdominal aortic aneurysm by general practitioners and practice-based ultrasonographers. J Med Screen 13 (2006), 160–161.
25 Duncan, J.L., Wolf, B., Nichols, D.M., et al. Screening for abdominal aortic aneurysm in a geographically isolated area. Br J Surg 92 (2005), 984–988.
26 Badger, S.A., Jones, C., Murray, A., et al. Implications of attendance patterns in Northern Ireland for abdominal aortic aneurysm screening. Eur J Vasc Endovasc Surg 42 (2011), 434–439.
27 Vazquez, C., Sakalihasan, N., D'Harcour, J.B., et al. Routine ultrasound screening for abdominal aortic aneurysm among 65- and 75-year-old men in a city of 200,000 inhabitants. Ann Vasc Surg 12 (1998), 544–549.
28 Lederle, F.A., Johnson, G.R., Wilson, S.E., et al. Prevalence and associations of abdominal aortic aneurysm detected through screening. Aneurysm Detection and Management (ADAM) Veterans Affairs Cooperative Study Group. Ann Intern Med 126 (1997), 441–449.
29 Schermerhorn, M., Zwolak, R., Velazquez, O., et al. Ultrasound screening for abdominal aortic aneurysm in Medicare beneficiaries. Ann Vasc Surg 22 (2008), 16–24.
30 Chun, K.C., Teng, K.Y., Van Spyk, E.N., et al. Outcomes of an abdominal aortic aneurysm screening program. J Vasc Surg 57 (2013), 376–381.
31 Jepson, R., Clegg, A., Forbes, C., et al. The determinants of screening uptake and interventions for increasing uptake: a systematic review. Health Technol Assess 4 (2000), 1–133.
32 Lee, T.Y., Korn, P., Heller, J.A., et al. The cost-effectiveness of a “quick-screen” program for abdominal aortic aneurysms. Surgery 132 (2002), 399–407.
33 Kim, L.G., Thompson, S.G., Marteau, T.M., et al. Screening for abdominal aortic aneurysms: the effects of age and social deprivation on screening uptake, prevalence and attendance at follow-up in the MASS trial. J Med Screen 11 (2004), 50–53.
34 Van Damme, H., Sakalihasan, N., Vazquez, C., et al. Abdominal aortic aneurysms in octogenarians. Acta Chir Belg 98 (1998), 76–84.
35 Mortality tables by gender in Belgium. Coverage: 1 January 1994-31 December 2012. Available at: http://data.gov.be/dataset/mortality-tables-gender. Accessed June 3, 2015.
36 Meecham, L., Evans, R., Buxton, P., et al. Abdominal aortic aneurysm diameters: a study on the discrepancy between inner to inner and outer to outer measurements. Eur J Vasc Endovasc Surg 49 (2015), 28–32.
38 Ogata, T., Gregoire, L., Goddard, K.A., et al. Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population: a case control study. BMC Med Genet, 7, 2006, 67.
39 Gretarsdottir, S., Baas, A.F., Thorleifsson, G., et al. Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Nat Genet 42 (2010), 692–697.
40 Behaviour of smokers in Belgium, 2014 Available at: http://www.cancer.be/sites/default/files/Fondation_contre_le_cancer_comportement_fumeurs.pdf Accessed June 3, 2015.
41 Durieux, R., Van Damme, H., Labropoulos, N., et al. High prevalence of abdominal aortic aneurysm in patients with three-vessel coronary artery disease. Eur J Vasc Endovasc Surg 47 (2014), 273–278.
42 Dupont, A., Elkalioubie, A., Juthier, F., et al. Frequency of abdominal aortic aneurysm in patients undergoing coronary artery bypass grafting. Am J Cardiol 105 (2010), 1545–1548.
43 Long, A., Bui, H.T., Barbe, C., et al. Prevalence of abdominal aortic aneurysm and large infrarenal aorta in patients with acute coronary syndrome and proven coronary stenosis: a prospective monocenter study. Ann Vasc Surg 24 (2010), 602–608.
44 Bergersen, L., Kiernan, M.S., McFarlane, G., et al. Prevalence of abdominal aortic aneurysms in patients undergoing coronary artery bypass. Ann Vasc Surg 12 (1998), 101–105.
45 Madaric, J., Vulev, I., Bartunek, J., et al. Frequency of abdominal aortic aneurysm in patients >60 years of age with coronary artery disease. Am J Cardiol 96 (2005), 1214–1216.
46 Nordon, I.M., Hinchliffe, R.J., Loftus, I.M., et al. Pathophysiology and epidemiology of abdominal aortic aneurysms. Nat Rev Cardiol 8 (2011), 92–102.
47 Irwin, C., Synn, A., Kraiss, L., et al. Metalloproteinase expression in venous aneurysms. J Vasc Surg 48 (2008), 1278–1285.