Reference : Modulating effect of COMT genotype on brain areas underlying cognitive control processes
Scientific congresses and symposiums : Unpublished conference/Abstract
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/201338
Modulating effect of COMT genotype on brain areas underlying cognitive control processes
English
Collette, Fabienne mailto [Université de Liège > Département de Psychologie > Neuropsychologie >]
Jaspar, Mathieu mailto [Université de Liège > Département de Psychologie > Ergonomie et intervention au travail >]
18-Mar-2016
Yes
Yes
International
Joint Meeting of the British Neuropsychological Society with la Société de Neuropsychologie de Langue Française
17-18 mars 2016
Londres
UK
[en] cognitive control ; fMRI ; genetic
[en] Catechol-O-methyltransferase (COMT) is an important enzyme which degrades catecholamines, such dopamine, notably in the prefrontal cortex. A large number of studies reported an effect on executive functioning of COMT genotype, each genotype being associated with a different COMT enzymatic activity. In this talk, I will present some of our studies that explored the neural substrates of inhibitory processes according to COMT genotype. These studies showed that COMT genotype modulates the brain-level implementation of proactive and reactive inhibitory control processes. We will discuss how individual differences related to DA-mediated signaling can differently influence inhibition in function of the form of cognitive control required by the task, but also regarding the specific inhibitory mechanism induced by the task.
Researchers
http://hdl.handle.net/2268/201338

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