MicroRNAs in large herpesvirus DNA genomes: recent advances.

[en] MicroRNAs (miRNAs) are small non-coding RNAs (ncRNAs) that regulate gene expression. They alter mRNA translation through base-pair complementarity, leading to regulation of genes during both physiological and pathological processes. Viruses have evolved mechanisms to take advantage of the host cells to multiply and/or persist over the lifetime of the host. Herpesviridae are a large family of double-stranded DNA viruses that are associated with a number of important diseases, including lymphoproliferative diseases. Herpesviruses establish lifelong latent infections through modulation of the interface between the virus and its host. A number of reports have identified miRNAs in a very large number of human and animal herpesviruses suggesting that these short non-coding transcripts could play essential roles in herpesvirus biology. This review will specifically focus on the recent advances on the functions of herpesvirus miRNAs in infection and pathogenesis.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Sorel, Oceane

Dewals, Benjamin G ; Université de Liège > Immunologie et vaccinologie

Language :

English

Title :

MicroRNAs in large herpesvirus DNA genomes: recent advances.

Publication date :

2016

Journal title :

Biomolecular Concepts

ISSN :

1868-5021

eISSN :

1868-503X

Publisher :

De Gruyter

Volume :

Issue :

Pages :

229-39

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 29 August 2016

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