Reference : MicroRNAs in large herpesvirus DNA genomes: recent advances.
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/201279
MicroRNAs in large herpesvirus DNA genomes: recent advances.
English
Sorel, Oceane [> >]
Dewals, Benjamin G mailto [Université de Liège > > Immunologie et vaccinologie >]
2016
Biomolecular concepts
7
4
229-39
Yes
International
1868-5021
1868-503X
Germany
[en] MicroRNAs (miRNAs) are small non-coding RNAs (ncRNAs) that regulate gene expression. They alter mRNA translation through base-pair complementarity, leading to regulation of genes during both physiological and pathological processes. Viruses have evolved mechanisms to take advantage of the host cells to multiply and/or persist over the lifetime of the host. Herpesviridae are a large family of double-stranded DNA viruses that are associated with a number of important diseases, including lymphoproliferative diseases. Herpesviruses establish lifelong latent infections through modulation of the interface between the virus and its host. A number of reports have identified miRNAs in a very large number of human and animal herpesviruses suggesting that these short non-coding transcripts could play essential roles in herpesvirus biology. This review will specifically focus on the recent advances on the functions of herpesvirus miRNAs in infection and pathogenesis.
http://hdl.handle.net/2268/201279
10.1515/bmc-2016-0017

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